The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.
Cambridge, MA
Joined November 2014
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Our October issue is now live!
Get ‘wrapped’ up in this month’s exciting microbiology.
cell.com/cell-host-microbe/c…
Microbial-derived methotrexate metabolite alleviates inflammation
Gut microbial metabolism of methotrexate generates DAMPA. DAMPA acts through STAT3 to promote mitochondrial function and protect against inflammation in context of IBD.
cell.com/cell-host-microbe/f…
Weekend revisit: Probiotics eradicate glioblastoma
E. coli Nissle produces bispecific engagers to recruit & instruct in situ-edited CAR macrophages. Microbe-guided CAR macrophages overcome glioblastoma antigenic heterogeneity & establish antitumor memory
cell.com/cell-host-microbe/a…
Hot paper revisit 🔥
lncRNA induces trained immunity against TB
Exosomal lncRNA TRCR1 derived from Mtb resisters induces trained immunity via CLOCK-mediated epigenetic reprogramming. Mycobacteria induces TRCR1+ exosomes, boosting immunity & BCG efficacy
cell.com/cell-host-microbe/a…
Microbial products trigger chemosensory dialogues via GPCRs
Libraries of gut metabolites+GPCR-seq reveal how gut senses environmental chemicals. ID microbial products activating specific receptors, including those triggering serotonin or linking to IBD
cell.com/cell-host-microbe/a…
Distinct BSHs in Bacteroides limit VRE
Bacteroidales mediate resistance to Vancomycin-resistant enterococci via subtype of bile salt hydrolases that retain uncleaved N-terminal signal peptide. T5 BSHs generate DCA that limits VRE
cell.com/cell-host-microbe/a…
Cell Host & Microbe retweeted
✨#SUSTech researchers publish new findings in @cellhostmicrobe, dissecting the complete immune pathway of the bacterial DRT2 antiphage defence system. This work expands our understanding of nucleic acid function and genetic information flow. 🧬
Read more: newshub.sustech.edu.cn/en/?p…
Cell Host & Microbe retweeted
From gut microbiota to cancer immunotherapy.
New research highlights how Akkermansia muciniphila may help overcome resistance to anti-PD-1 therapy in colorectal cancer.
An encouraging direction for microbiome-based approaches, with clinical evidence still at an early stage.
Akkermansia enhances anti-PD-1 efficacy
A. muciniphila attenuates macrophage efferocytosis to overcome PD-1 resistance in microsatellite-stable colorectal cancer (MSS CRC). Phase 1 trial supports microbiome modulation to improve immunotherapy in MSS CRC
cell.com/cell-host-microbe/f…
Weekend revisit!
VIBRANT: Phase 1 trial of multi-strain L. crispatus for BV
Women w/bacterial vaginosis receiving multi-strain vaginal L. crispatus live biotherapeutic 3–7d post antibiotics showed vaginal colonization up to 12 wks, reducing recurrent BV
cell.com/cell-host-microbe/a…
Microbial-epigenetic-circadian axis orchestrates nutrient absorption
Microbial inositol phosphates translate feeding time into diurnal rhythms via HDAC3, activating nutrient absorption--promoting growth during undernutrition & obesity upon overnutrition
cell.com/cell-host-microbe/f…
Phage small RNA mimics chimeric guide to inhibit CRISPR-Cas9
rAcrIIA1 is phage-encoded chimeric crRNA-tracrRNA mimic that blocks Cas9 guide loading & DNA interference. This reprogrammable RNA guide enables genome editing, gene silencing & diagnostics
cell.com/cell-host-microbe/a…
Discovering phage defense systems through modularity networks
Modular organization of bacterial immune systems is used to ID phage defense systems. 3 systems in P. aeruginosa reveal strategies against jumbo phages & RM-like system w/additional components
cell.com/cell-host-microbe/f…
Akkermansia enhances anti-PD-1 efficacy
A. muciniphila attenuates macrophage efferocytosis to overcome PD-1 resistance in microsatellite-stable colorectal cancer (MSS CRC). Phase 1 trial supports microbiome modulation to improve immunotherapy in MSS CRC
cell.com/cell-host-microbe/f…
Akkermansia protects against endometritis
A.muciniphila protects against endometritis by driving tyrosol production, which reaches uterus & suppresses inflammation. Work reveals metabolite-mediated gut-uterus axis linking microbiota to reproductive health
cell.com/cell-host-microbe/f…
Gemella morbillorum promotes CRC
Colonization of the colon by G. morbillorum increases intestinal permeability, enables epithelial cell invasion, reshapes host lipid metabolism & triggers DNA damage, collectively accelerating colorectal tumorigenesis
cell.com/cell-host-microbe/f…
C. auris turns skin immunity to its advantage
Preview of @ScienceMagazine paper showing C. aurisoccupies hair follicles & exposes chitin, triggering IFN responses that remodel follicular keratinocytes to promote fungal persistence
cell.com/cell-host-microbe/a…
Microbial chromatin remodeler drives cancer progression
S.anginosus promotes gastric immune evasion via EVs delivering bacterial chromatin remodeler to host cells, co-opting TEAD1 to⬆️ZDHHC11 & stabilize PD-L1. Targeting axis potentiates anti-PD-1 therapy
cell.com/cell-host-microbe/f…
Cell Host & Microbe retweeted
"Akkermansia muciniphila protects against endometritis through a tyrosol-mediated gut–uterus axis."
Learn more in Cell Host & Microbe: cell.com/cell-host-microbe/f…
Jiuxi Liu, Xufeng Xie, and Yongguo Cao
@cellhostmicrobe
ALT grpahical abstract
Preview: When microbial biofilms build kidney stones
C. glucuronolyticum-like bacteria are urinary pathobionts that promote CaOx crystallization via (1) degradcrystallization inhibitor hippuric acid & (2) biofilm-mediated crystal aggregation
cell.com/cell-host-microbe/a…
Bacteria promote kidney stones
C. glucuronolyticum-like bacteria enriched in urine of calcium oxalate stone patients & promote CaOx crystallization via hippuric acid degradation & biofilm formation. Hippuric acid prevents bacteria-driven crystallization
cell.com/cell-host-microbe/a…
Protein landscape of chromatin domains in Plasmodium
Resource provides comprehensive characterization of chromatin-associated proteins in P. falciparum, revealing insights into parasite gene regulation, transmission & cell cycle control
cell.com/cell-host-microbe/f…
