@foldingathome

We are a group of academic labs around the world that perform biomedical research using the computing power of volunteers | Join us at: https://xitter.cf/t.co/H7f8sORsMs

 University of Pennsylvania
foldingathome.org
Joined May 2008
  • Tweets1.9K
  • Following39
  • Followers27.3K
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🚨🚨🚨NEW SOFTWARE RELEASE!🚨🚨🚨 Help advance biomedical research by downloading/installing our new client software from foldingathome.org/start-fold… This release has an improved UI and the option to control all the machines you have running Folding@home from a single webpage
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Happy new year! 2024 was a productive year, and 2025 stands to be even more exciting! Our thanks to everyone who helped, and some reflections: foldingathome.org/2025/01/09…
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Too many requests for money this Giving Tuesday? Consider giving your spare CPU/GPU cycles to advance biomedical research instead! Download our software and join our community of citizen scientists here: foldingathome.org/start-fold…
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If you prefer the traditional approach, we also welcome tax-deductible gifts every.org/foldinghome-founda…

Folding@home Foundation | Every.org

We empower anyone to become a citizen scientist and fight global health threats by donating their unused computer power.

every.org
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Wow, cool to see that team Banana has overtaken "Default (No team specified)", closely followed by LinusTechTips! @bananocoin @LinusTech
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We're making good progress on predicting properties of small molecules that are important determinants of whether they can be good drugs. Read more! foldingathome.org/2024/10/03…
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Want to do something meaningful with your computer? Contribute your computing power to Folding@home to accelerate biomedical research! foldingathome.org/start-fold…
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Congratulations to Susanna @SusannaBar2 from Mitchell group @ChemistryUIUC and Song from @ShuklaGroup @ChBEIllinois for their work on understanding how enzymes tie the lasso knot in peptides published in Nature Chemical Biology @nchembio! igb.illinois.edu/article/res…
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Exciting new work on why the cryptic pockets that we've been hunting for exist foldingathome.org/2024/09/09…
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Now available open access! AlphaFold and Protein Folding: Not Dead Yet! The Frontier Is Conformational Ensembles annualreviews.org/content/jo…

AlphaFold and Protein Folding: Not Dead Yet! The Frontier Is Conformational Ensembles

Like the black knight in the classic Monty Python movie, grand scientific challenges such as protein folding are hard to finish off. Notably, AlphaFold is revolutionizing structural biology by...

annualreviews.org
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Woohoo, our paper on the mechanism of a G protein inhibitor that is specific to one family of G proteins is out! Nice collab with the Blumer nad @AndreaSoranno labs pnas.org/doi/10.1073/pnas.23…
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Congrats to team AFGamers on jumping 691 positions on the leader board!
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Its always fun to see how natural selection uses everything at its disposal, including rare protein structures that are hard to even detect. Even when this cryptic pocket is only open ~2% of the time, its still performing an important function.
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This cryptic pocket has a function! The VP35 protein from Ebola virus performs multiple functions. We wanted to know if it toggles between different conformations that are responsible for different functions. It does! biorxiv.org/content/10.1101/…

The probability of cryptic pocket opening controls functional tradeoffs in filovirus immune evasion

Cryptic pockets are of growing interest as potential drug targets. However, it remains unclear whether they contribute to protein function or if they are merely happenstantial features that can...

biorxiv.org
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Data organization is up to 17 milliseconds of simulations, taking 22 TB on disk, and still just getting started😀 #compchem @foldingathome
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Congrats to walterthurmond on jumping 855 positions on the leader board! Thanks walterthurmond for contributing!
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Exciting to see our illustrious founder continuing to do great things!
a16z
@a16z12 Aug 2024
When it comes to the intersection of AI and life sciences, there are few more qualified to tell the story than @vijaypande. In 1999, Vijay started working on Folding@Home, when the internet was still new, harnessing the power of volunteers’ PCs to help scientists develop new therapeutics. 👇
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Folding@home retweeted
Vijay Pande
@vijaypande9 Aug 2024
2/ I recently joined the AI + @a16z podcast, to discuss this plus: * My work developing the @foldingathome, a distributed computing project to harness global computational power for biological research a16z.com/podcast/why-compute…

Why Computer Science Subsumed Biotech | Andreessen Horowitz

Vijay Pande walks us through two decades of applying software engineering and AI to biotech and health care — from Folding@Home through AlphaFold and more.

a16z.com
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Check out our rig😀 foldingathome.org/2024/08/08…
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Folding@home retweeted
Greg Bowman@drGregBowman5 Aug 2024
Thanks to everyone @foldingathome for helping generate this! For reference, a good paper in our field may have 10 microseconds of data. So 2.1 milliseconds of data is like having 210 papers worth of data. And that's just the tip of the iceberg!
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If you are working in distributed computing and need to build / be motivated on the usage of distributed computing - just make sure you are aware of @foldingathome Fold is a brilliant concept which caught a lot of attention during the covid19 phase. Mainly for protein folding. foldingathome.org/ Always a pleasure to go back and see the magic of Fold. Big thanks to @drGregBowman for this !
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