@gcfmd
 Los Angeles, CA
Joined December 2012
  • Tweets12.1K
  • Following178
  • Followers12.7K
2.4KMedia
Gregg Fonarow MD retweeted
Journal of Cardiac Failure@JCardFail3h
💰 The broader annual cost burden of Heart Failure (HF) is projected to reach $858 billion by 2050. Yet, we hold an extraordinarily cost-effective solution in our hands today. See below for more + click here for more insights from our HF STATS 2026 report bit.ly/3ULm2vS
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💊Is evolocumab cost-effective before a first MI or stroke? 
📊 VESALIUS-CV lifetime model at $3,107/yr 
❤️ −0.24 MACE/person 
✅ ICER $71,162/QALY; scenarios $20K–$51K 
🎯 All below the $120K AHA/ACC threshold 
⚠️ Preprint 
🔗 doi.org/10.64898/2026.07.23.…
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💊 PCSK9 inhibitors in the US, Oct 2026: 
💉 Repatha: ~60%↓LDL | CVOT ✅ | $239/mo 
💉 Praluent: ~45–60% | CVOT ✅ | $225/mo 
🩺 Leqvio: ~50% | CVOT ⏳ | no DTC 
💉 Lerochol: ~56–60% | CVOT ❌ | $199/mo 
💊 Lipfendra (oral!): ~56–59% | CVOT ⏳ | $315 list 
 #Lipids
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Trial after trial, vitamin D supplements keep coming up empty: 💊 VITAL (25,871): no CV benefit 
🧬 83,000 across 21 RCTs: null 
💀 80 RCTs: no CV benefit 
🩺 SIMPLIFIED (2026, dialysis): no ☠️ benefit, HR 0.94 Billions spent on RCTs Still nothing Low D is a marker
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Gregg Fonarow MD retweeted
HFSA
@HFSAOct 23
👏 Congratulations go out to Amrut Ambardekar, MD, FHFSA of the University of Colorado Health for being named this year's Distinguished HFSA Service Award winner at #HFSA2026 Learn more 👉 youtube.com/watch?v=T_AGfOX4…
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Gregg Fonarow MD retweeted
Ahmed Bennis MD 🫀
@drbennisahmedOct 23
CMS's 2027 HF model has no measure for MRAs or SGLT2i, and doesn't require ARNI. Modeled: every eligible U.S. HFrEF patient on all 3 at generic prices (~$227/yr) could prevent ~87.5K deaths and save ~$14.1B net per year. Keykhaei et al, JACC HF 2026
#HFrEF #Cardiology
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💊 Does stopping cardiovascular meds make patients feel better? 
🔬 6 deprescribing RCTs, 3,748 older/frail patients 
😐 QoL better in just 1 of 5 
⚠️ Adverse events reduced: 0 of 6 
⚖️ Death/hospitalization better: 0 of 6 
🚫 Rarely helpful 😳 
#Deprescribing
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🫀 Quadruple guideline-directed medical therapy (GDMT) offers a profound mortality benefit, yet it remains severely underutilized across Heart Failure (HF) care today. Data from HF STATS 2026 reveals only 18% of patients with HFrEF receive all 4 foundational medication pillars.
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Gregg Fonarow MD retweeted
HFSA
@HFSAOct 22
🌟🏅Congratulations to the winner of this year's HFSA Distinguished Mentor Award, Lynne Stevenson, MD of Vanderbilt University Health, for her leadership and mentorship in the #HeartFailure field! #HFSA2026 Stay tuned for more award announcements! Learn more about Lynne Stevenson, MD here 👉 youtube.com/watch?v=sUci1Cgi…
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❓for @CMSGov Why does the 2027 HF ASM measure beta-blockers and RASi 💊 but not ARNI, MRA or SGLT2i? Those 3 could prevent: ~88K deaths 💔 a year ~746K 🏥 a year Saving $14.1B 💰, at $227/yr per patient What are we missing? 🤷 @ACCinTouch @American_Heart @HFSA @AAHFN
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Gregg Fonarow MD retweeted
TCTMD
@TCTMDOct 21
Heart failure care has advanced, but the US burden continues to grow. A new report shows mortality is rising as more Americans are being affected, with obesity, diabetes, and other comorbidities potentially contributing to the trend. #HeartFailure #PublicHealth bit.ly/4rZGy8a
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🚨 @CMSgov's 2027 HF Ambulatory Specialty Model leaves out ARNI, MRA & SGLT2i 🤯 Adding optimally each year: 💔 87,537 deaths prevented 🏥 746,196 hospitalizations avoided 💰 $14.1B net savings 💊 All 3 generic: $18.90/mo on Cost Plus Drugs Fix it now! #HFrEF #GDMT @HFSA
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🫀 Ready to make a difference in #HCM care? The @American_Heart Hypertrophic Cardiomyopathy Registry is enrolling! 📊 National HCM registry
🏆 Hospital QI recognition
📜 Hospital & pro certification
🩺 Patient support
🤖 AI detection pilot 
👉 heart.org/hcmregistry
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🚑 ICH patients reach the ED faster than those with ischemic stroke (median 127 vs 175 min from last known well) 🧠 But once stroke severity is accounted for, they're LESS likely to meet ED care targets ⏱️ Time is brain for ICH too 📄 Royan et al, doi.org/10.1001/jamanetworko…
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💊 Starting HFrEF GDMT: 8 landmark RCTs, 30,523 pts, ~55,600 patient-yrs, 6,725 deaths/HF events 
🛑 Stopping GDMT after EF recovery: 5 pilot RCTs, 313 pts, ~300 patient-yrs, surrogates only 
⚖️ ~180× less follow-up 
📕 Keep GDMT going until real RCTs say otherwise
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Gregg Fonarow MD retweeted
Ahmed Bennis MD 🫀
@drbennisahmedOct 21
GDMT is Associated with Reduced Loop Diuretic Requirements, Whereas Diuretic Dose Does Not Modify GDMT Benefit in Heart Failure: STRONG-HF. GDMT optimization acted as diuretic-sparing therapy: reaching target doses, particularly of all three classes, was associated with markedly lower LD requirement. @hfcollaboratory @gcfmd @SJGreene_md @mvaduganathan academic.oup.com/eurjhf/adva…
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🧠 New in @JAMANetworkOpen: ICH vs ischemic stroke in 195,659 EMS arrivals GWTG-Stroke, 2015–24 🚑 ICH patients arrive at the ED faster 
⏱️ But once adjusting for stroke severity, they're LESS likely to hit ED targets (MD ≤10 min, imaging ≤20 min) Time is brain for ICH too!
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Timeliness of Emergency Care for Intracerebral Hemorrhage Compared With Acute Ischemic Stroke doi.org/10.1001/jamanetworko… @AHAScience @AHA_Research @JAMANetworkOpen @JAMA_current @Braindoc_MGH @VCI_EricSmith @American_Stroke #GWTG

Timeliness of ED Care for Intracerebral Hemorrhage and Acute Ischemic Stroke

This cohort study evaluates differences between prehospital and emergency department (ED) process quality metrics among patients with intracerebral hemorrhage and acute ischemic stroke.

jamanetwork.com
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🫀📡 New in JACC: Heart Failure: AI-guided monitoring after HF discharge was feasible, but didn't cut re-🏨 or ED visits/readmission/death 🏥 5 VA centers | 🩹 chest patch up to 90 days Feasible ≠ effective 📉❌ #HeartFailure #DigitalHealth @JACCJournals
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🫀 Heart failure contributes to ~1 in 7 US deaths (457K/year) 💵 NIH $ per death: 
🧬 HIV ~$717K
🧠 Alzheimer's ~$31K
🎗️ Cancer ~$13K
🫁 COPD ~$824
❤️‍🩹 HF ~$440 (est.) HF gets ~1,600× less than HIV per death Fund HF research!!!📢 @HFSA @ACCinTouch @American_Heart
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