@loyalfordogs

We’re developing the first drugs intended to help dogs live longer, healthier lives 🐕

Joined October 2020
We're getting closer to the first longevity drugs for dogs. Hear about our latest progress from the team making it happen → hubs.la/Q04xXVds0
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LOY-003, our pill for large- and giant-breed dog lifespan extension, completed the efficacy section (RXE) of its conditional approval application.
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Hear from our chief scientist on what this milestone means for LOY-003 and our strategy for developing the first longevity drugs for dogs → loyal.com/LOY-003-RXE
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Loyal retweeted
After 5 years, I am still excited to be a part of this team and this work!
When we started Loyal there was no FDA pathway for a any lifespan extension drug. Today the FDA accepted our third one! LOY-003, our daily pill for helping large dogs live longer (and healthier) lives, has earned RXE efficacy approval.
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Congrats to the Loyal team! 🐶 @celinehalioua has been talking about this drug since the earliest days of Loyal. Very exciting!
When we started Loyal there was no FDA pathway for a any lifespan extension drug. Today the FDA accepted our third one! LOY-003, our daily pill for helping large dogs live longer (and healthier) lives, has earned RXE efficacy approval.
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We’re one step closer to the first FDA-approved longevity drugs for dogs 🐶🎉 Now, all three drugs currently in our portfolio have met the FDA’s efficacy requirements for conditional approval, a first for any pharma company.
When we started Loyal there was no FDA pathway for a any lifespan extension drug. Today the FDA accepted our third one! LOY-003, our daily pill for helping large dogs live longer (and healthier) lives, has earned RXE efficacy approval.
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Learn more about our latest regulatory progress → loyal.com/LOY-003-RXE
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Four quick polls from the Loyal team: Are you a dog owner or veterinary professional?
86%Dog owner
0%Veterinary professional
4%Both
11%Neither! Just a dog lover
28 votes • Final results
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Every dog ages differently: Which sign of aging stands out in your dog or patients?
47%Loss of mobility
20%Signs of pain
13%Loss of appetite
20%Diseases of aging
15 votes • Final results
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Pick a topic: What are you most interested in learning about?
27%How dogs age
7%Nutrition and diet
33%Healthspan vs. lifespan
33%Supplements for dogs
15 votes • Final results
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The A-Word: The Future of Aging premieres tonight at the 25th @Tribeca Film Festival. An independent documentary about growing old well and the founders and scientists working to add life to years. It's honest, hopeful, and our founder @celinehalioua is one of the voices in it.
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Congratulations to Reel as Dirt, Cityspeak Films, and everyone who brought it to the screen. Learn more about the film or find tickets to see it in person: theawordfilm.com/
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"If we pull this off, my team will be responsible for potentially millions of dog years that wouldn't have otherwise existed." Learn more about our journey in @BainCapVC 's latest Outlier Briefing with @kevinzhang and @celinehalioua → youtu.be/LXqF5tohXt8
This startup wants dogs to live longer. If that’s not enough to get you to watch, we’re not sure what will. But if you need more convincing, @celinehalioua built @loyalfordogs after years of doubt and is now running the first ever FDA-concurred lifespan extension clinical trial. Featuring 1,300 really good boys and girls. And yes, everyone will get a pup cup after. Full Outlier Briefing with @kevinzhang out now.
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Six years ago, people laughed at the idea of a longevity drug for dogs. Now, we're on-track to develop the first FDA-approved drug for lifespan extension. Our founder and CEO @celinehalioua joined @BenMillerise to talk through all of it.
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NEW Exclusive Interview: This miracle pill could make dogs live longer, with Celine Halioua, Founder & CEO of Loyal @celinehalioua is building the first drug ever FDA-approved for lifespan extension itself — starting with dogs. We sat down on Onward to talk about why she thinks longevity is the most under-built frontier in medicine and what’s next for @loyalfordogs. We cover: Why the U.S. healthcare system structurally can't build preventative medicine The "micro single-payer" reason dogs are the perfect first market "Save the dogs, save the world" — Loyal's Tesla-style master plan The September 2019 FDA pathway change that made the entire company possible Why big dogs die young (growth hormones that never turn off) Caloric restriction mimetics — the second drug, for dogs of any size Why drug development is mostly logistics and economics, not science Scenario planning the next five years of biotech Why Loyal is AI-resistant and AI-amplified Being fired (and rehired) from the longevity fund — twice Bottom 10% of her high school class → Oxford → dropping out six months from her PhD Watch the full episode below → 𝐓𝐈𝐌𝐄𝐒𝐓𝐀𝐌𝐏𝐒 (00:00) Celine Halioua, Founder & CEO of Loyal (01:36) What is Loyal? (02:29) Why big dogs die younger (05:47) How the second drug works (08:22) First longevity drug in history (09:37) Why longevity drugs never existed (16:13) The master plan (18:23) Private vs Public (20:00) Three steps to market (25:55) The regulatory loophole (29:27) Scenario planning (31:54) AI and drug development (35:42) Good scenario (38:03) Bad scenario (39:35) Unexpected scenario (44:06) Why Fundrise (49:27) Founding story
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Modern medicine treats diseases one-by-one, but what if aging itself is the root cause? The A-Word: The Future of Aging follows Loyal Founder & CEO @celinehalioua in her journey to develop the first FDA-approved longevity drug and other scientists racing to extend lifespan.
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Before she founded @loyalfordogs, @celinehalioua got her love of science from her mom. She didn't consider herself a science-y kid growing up. But after doing middle school science fair projects with her mom (including an assessment of the price-to-value ratio of canned green beans), she took to it. Now Celine does research every day, as Loyal works to develop the first-ever drugs to help dogs live longer, healthier lives. Beginnings matter.
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