Stuart Buck (@stuartbuck1) header
Stuart Buck (@stuartbuck1) profile picture

Executive Director, https://teapaw.org/t.co/sgoEDJXzzA Formerly: @arnold_ventures, @harvard_law, @kellogghansen Classical guitarist and author

Georgia
Joined June 2011
Photo by Stuart Buck (@stuartbuck1)Photo by Stuart Buck (@stuartbuck1)Photo by Stuart Buck (@stuartbuck1)Photo by Stuart Buck (@stuartbuck1)Photo by Stuart Buck (@stuartbuck1)Photo by Stuart Buck (@stuartbuck1)Photo by Stuart Buck (@stuartbuck1)Photo by Stuart Buck (@stuartbuck1)Photo by Stuart Buck (@stuartbuck1)
Funny how everyone who is optimistic about AI "curing disease" in the next 10 years either 1) has zero training in biology/medicine, or else 2) works for an AI company selling its book.
This recent story about the high profile failure of two promising heart disease drugs is a great example of the kind of work that AI has cut out for itself to do. Even at the end of the trials, the doctors and scientists who did it are wondering if they picked the wrong mechanism, the wrong trial or the wrong patient population. This was in spite of the best data that they had which was suggestive of the intervention. Drug discovery remains incredibly hard because biology is so ill-understood. AI can certainly contribute insights and speed up parts of the process, but the idea that it can somehow magically prevent these kinds of failures is akin to a religious belief. nytimes.com/2026/11/07/scien…
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Stuart Buck retweeted
it annoys me so much that media portrays plastic as a purely evil material that we're terrible for still using. replacing your straw isn't going to do anything if hundreds of millions of tonnes are still being produced annually, it just makes you feel better for 'trying'. like concrete or gas, an alternative needs to scale it's useful to stop and notice that all the properties that made plastic so popular are the same ones that we dislike. you cannot have one half of what the properties enabled without the other. some notes on what's actually hard about replacing plastic: chandhana.blog/p/plastic
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Stuart Buck retweeted
Terrible day for would-be lone wolf bioterrorists who also receive federal grants and order exclusively from US sphere of influence suppliers
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"AI is going to solve all biology and human disease"! Meanwhile, we don't even have enough data about basic human anatomy, let alone about things like cellular vaults.
Two 19-year-old Tulane University sophomores discovered a previously unknown muscle attachment deep in the human hip during a routine cadaver lab session — a find so unusual that even their professor, a co-editor-in-chief of Gray's Anatomy, couldn't identify it. Dominic Roy and Cooper Bruce had been assigned to measure the fusion point between two well-known hip muscles when Roy spotted something unfamiliar on the other side of the iliac fascia. After an exhaustive search through medical literature and textbooks turned up nothing, the team confirmed it was a new anatomical discovery. The findings were recently published in the journal Clinical Anatomy. Full story here foxnews.com/health/college-s…
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AI will accelerate some aspects of competitive intelligence gathering and portions of research, but not in the way that it is commonly hyped. The main limitation is that molecular interaction prediction, let alone kinetics of interaction prediction, is not remotely a solved computational problem. Biology hinges so extensively on binding kinetics that this precludes AI from “solving” biology simply with more compute. This is a fundamental difference between biology and math, computer science, or boilerplate drafting. There are ways forward but the road is much longer than many non-biologists would like to assume. wsj.com/tech/ai/silicon-vall…
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Stuart Buck retweeted
New paper: "Replication Certification at Publication: Checkable by Anyone, Anywhere, in Seconds, Forever" GaryKing.org/certify. with @xuyiqing & @YangYang_Leo. Comments welcome!
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Stuart Buck retweeted
What it’s like to run President Trump’s science and technology office.
A few weeks ago, the Secret Service locked Jensen Huang, Elon Musk, Sergey Brin, Satya Nadella, Lisa Su, and Michael Dell in a room in Washington, DC. While they waited for President Trump, Huang—who chooses not to own a jet—complained about a recent commercial plane ride. It had no Wi-Fi. “Best way to sandbox an AI,” Musk said. “Put it on a Delta flight.” All six were about to receive national medals from the President. The ceremony was the idea of Michael Kratsios, Trump's chief science advisor. He is 39, a Peter Thiel protégé, and has worked for Trump every day of both terms. For decades, the office Kratsios runs was known mostly for reports on things like algae blooms. Kratsios himself was barely known in Trump's first term. Now he sits between the President and tech royalty. He is one of a handful of people shaping America's AI policy, and the White House's point man on nuclear, space, and quantum. In our latest feature, @harrytlambert shows how the fight to regulate AI and reform American science runs through his office. colossus.com/article/michael…
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Once I was delayed for 8 hours in the middle of winter at O'Hare in Chicago. When we were finally boarding, a pilot deadheading was right in front of me. I asked him what he knew about the delay, and he said that conditions at altitude had been really icy. I asked what that would mean, and he said, "If the plane ices up, then it would just nosedive into the earth." I said, "You know, I don't mind the 8-hour delay so much any more."
Per transcript and telemetry, aircraft encountered extreme high altitude icing conditions with heavy precip at 47 degrees below zero. It essentially became a rock with engines and nosedived nearly 40,000 feet in a minute or two. Just a terrible situation, this is why meteorology is so critical in aviation
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Can't believe this 1969 doc was using AI (look at all the em-dashes):
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Stuart Buck retweeted
This is actually a phenomenal social experiment on false authority over time leading to obedience
Reffing at LA fitness
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Stuart Buck retweeted
this is the craziest result in economics I saw someone present this year. it should prompt a deep re-examination of what field experimental social science should look like in the years to come.
New working paper: Can AI forecast treatment effects in economics from pre-registration documents? Answer: Yes. 1/
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Stuart Buck retweeted
We're recruiting a cohort of metascience fellows to deploy in federal research agencies at a moment when they can have enormous impact. A pretty fantastic opportunity. More below
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Overheard in NY just now: Man at the next table: "Wait, you don't know what Sesame Street is?" Woman: hems and haws Man: "you actually thought it was like Jane Street?!" Woman: "well I thought it was an imitation."
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This should have been more viral; it got sent around in an internal Jane Street channel on Slack :)
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An idea: maybe it makes sense for a major federal science funding agency to be led by someone with a track record of picking top talent across multiple fields.
Exceptional talent is widely distributed. Permission to use it is not. We started the Thiel Fellowship to find extraordinary young people and give them the freedom to pursue ambitious ideas. Fifteen years later, see what they’ve built.
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Stuart Buck retweeted
There is this lie we all secretly believed : if a friendship is real, it will always feel like it does right now. You remember that version. Three hour calls about nothing. Replying in 0.3 seconds. Seeing a meme and sending it to five people because all of you were permanently online. You could tell who was upset by the way they typed “lol.” You knew their class schedule, their crush rotation, their favorite cereal. Friendship felt like constant contact. Then somehow one day it does not. Now your closest friend might reply two days later with “sorry just seeing this.” You stare at that sentence with a small sting, even though you wrote the same thing to somebody else last week. They cancel plans because they are exhausted in a way that has nothing to do with sleep. You reschedule and then you cancel. Whole months pass in voice notes and “we need to catch up soon” and screenshots of flights you might take someday. It starts to feel like being quietly broken up with in slow motion. Nobody warns you how much admin adulthood stacks on top of love. Rent, sick parents, work that bleeds past office hours, kids, therapy, bodies that suddenly need more maintenance, nervous systems that finally crack after ten years of pretending to be fine. Everyone is trying to be a decent partner, decent coworker, decent child, decent human in a world that feels like a rolling crisis. Of course the part of you that once had energy to send 17 updates a day is tired. Less communication is not automatically less love. But it is a different shape of love, and that is the part that hurts. Because the scared part of you still keeps score like a 16 year old. They have not texted in a week. They viewed my story but did not answer my message. They were online. They posted. They made time for someone else. It does not matter how many bills you both have now. The kid inside still measures affection in frequency, not capacity. Adult friendship asks you to grow a second lens. One that can hold “I miss how it was” and “they are not abandoning me, they are surviving.” One that understands that sometimes your friend did not text back because they spent all day trying not to cry in a bathroom at work. Sometimes they are not ignoring you, they are in the same fog you are. Grace is not “let them treat me however.” Grace is “I will not confuse silence with betrayal unless they show me it is.” Check in, not out. It sounds simple until your own pride gets involved. There will be days you tell yourself “if they wanted to, they would have reached out” and use that as a reason to lock your phone. You call it a boundary. Often it is defense. It saves you from the vulnerability of being the one who sends “hey, how is your brain” after three months of nothing. It protects you from the possibility that they really have drifted. So you opt out quietly, tell yourself a story about how people change, and let something beautiful die out of sheer fear of going first. What if checking in is not humiliation. What if it is maintenance. Sometimes check in is not a deep talk. It is a dumb reel sent at 22:37 with “this is so you.” It is a voice note that says “I drove past our old place and wanted to throw up from nostalgia, how are you.” It is a “thinking of you, no need to respond.” You would be shocked how many people cry over those three words in grocery store aisles and parking lots. And sometimes, yes, what you find when you check in is that the thread is gone. They give you one word answers. They do not ask anything back. They leave you on delivered until it becomes obscene. That is information. Grace does not mean pretending that is fine. It means you can let it hurt, let it be real, and still not turn it into a courtroom in your head. You can grieve without inventing a villain. Adult friendship is two people saying, over and over, in a hundred tiny ways: I did not forget you. I am just carrying a lot. Thank you for still knocking.
Ngl, adult friendships require grace. People are very busy. People are healing. People are growing. People are taking time for self care just like you. Less communication isn't less love. Check in not out.
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The birth of optogenetics, whose pioneers won the Nobel Prize this year (!), is interesting because it developed almost randomly. The history of this field (from @ayanobacter) can help us truly understand discovery...and train better AI for science. amplifypartners.com/blog-pos…
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I'm dying to know what he said about Sesame Street before, e.g.: "So you know how in Sesame Street, Kermit the Frog and Miss Piggy are always . . . wait, why do you look confused?"
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A few warm fatherly tears shed today by an empty fort in the woods, so lovingly built, and so lately left, by a growing child with (quite rightly) more grown up things to do. I wish I could find her in there peeking out again, just a little smaller. Too fast; it is all too fast.
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We can't brute force compute all possible moves in Go, a static game with a simple 19 x 19 grid, yet somehow people think we're going to simulate a dynamic system of trillions of cells each containing trillions of molecules.
If you had an exponential amount of compute you could solve simulate biology exactly and wouldn't need to run any experiments. Some of you will think "of course, but that's an unrealistic assumption" and others will think "no, you need experiments even with that much compute. That's just How It's Done". You would of course need evaluations once you have a solution, but you don't in principle need experiments to find it: Experiments are a way to save compute, dating from a time when it was much more expensive. And I think the presentation is exponential but real systems aren't irreducibly exponential. AlphaFold worked, after all.
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