Circulation Research is an AHA journal focusing on basic science & translational cardiovascular research. https://xitter.cf/t.co/DbXiggw5ZE https://xitter.cf/t.co/ElAzkCBwac
Joined October 2009
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Zuela-Sopilniak & colleagues found that #NE rupture is a causal disease driver in #LMNA #DCM. Learn how abnormal gene expression arises downstream of NE rupture rather than from defects in transcriptional regulation at ahajrnls.org/3UJD4dO
Ramos-Hernández et al found protein degradation as a disease mechanism that can amplify the consequences of abnormal #calcium handling in catecholaminergic polymorphic ventricular tachycardia (#CPVT). Learn more at ahajrnls.org/4BqDYMQ
@ELaraPezzi @silviapriori1
Jiang & colleagues found a novel immune pathway linking #lupus to pulmonary #vascular complications. Learn more about the drug #belimumab that may treat the disease at ahajrnls.org/4z2gufh
@CircRes Oct 23rd Issue is Out! ahajrnls.org/3wPOBJJ
Cover: Activated T cells engage a susceptible endothelial-cell subpopulation through Fas ligand–Fas signaling, inducing endothelial apoptosis & contributing to remodeling of the pulmonary microvascular wall.
CALL FOR SUBMISSIONS!
@circres welcomes submissions for not one, but two upcoming compendia. Click the link for more details:ahajrnls.org/3O66En5
Linke & colleagues reveal that #Novex-3, a small and previously understudied form of the muscle protein #titin, helps maintain heart muscle structure & function. Learn more at ahajrnls.org/4i2KwbA
Wang & colleagues found that #microRNA released from #fat cells can travel in the blood, ultimately damaging the lining cells of vessels & therefore hardening the #arteries. Learn more at ahajrnls.org/4BdanGo
Zhang et a created a 3D human cardiac #organoid platform, derived from stem cells which captures the hallmark features of myocardial #fibrosis & offers a powerful new system for discovering antifibrotic therapies at ahajrnls.org/4jJxaUj
@Joseph_C_Wu @XiuLiu266
1/5 New #DiscoverCircRes episode! linkly.link/2wgwk@StHilaireL… chats with Drs. David Rawnsley, Xumin Guan & Abhinav Diwan about their study, Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function@Polash_23 linkly.link/2u5R4
4/5 Inducing CD8+ Tregs Limits Atherosclerosis via Notch-Mediated VSMC Quiescence by Gao et al @Kathyolui tinyurl.com/536xj4z5
5/5 Cytomegalovirus Latency Fuels Inflammation Following Myocardial Infarction by @ElenaDapergola and Marko Šustić et al @ImmunoCardioLab tinyurl.com/3564tack
Er & colleagues found a novel calcium channel modulator normalizes #mitochondrial function & reverses #HCM & #fibrosis in translationally relevant models. Learn more at ahajrnls.org/4jkOtuu
@livia.hool @alice-francis-ajf101
Shi & colleagues found the RNA-binding protein muscle blind-like protein 2 (#MBNL2) promotes alternative splicing of tropomyosin 3 (#TPM3) which contributes to #CardiacHypertrophy. Learn more at ahajrnls.org/47amwyl
Kogami et al found #stanniocalcin-1 is produced in response to increased pressure & helps protect blood vessels in the lungs from abnormal cell growth. Learn more about treating #PAH at ahajrnls.org/4zNwP7R
Heianza & colleagues found fasting blood metabolomic signatures that predict elevated 1-hour glucose reflect disease pathophysiology & #CHD through dietary interventions. Learn more at ahajrnls.org/4B17WGZ
Gao et al found boosting a specific type of immune cell, CD8⁺ #Tregs, switch artery muscle cells back to quiet, healthy mode through #Notch signaling, offering a new way to stabilize #atherosclerotic plaques. Learn more at ahajrnls.org/4dwhG1R
@Kathyolui
@CircRes Oct 9th Issue is Out! ahajrnls.org/3wPOBJJ
Cover: Lineage tracing shows accumulation of VSMC-derived macrophage-like cells (yellow) within an atherosclerotic plaque, a key pathogenic process that can be inhibited by CD8⁺ Tregs;nuclei-blue
CALL FOR SUBMISSIONS!
@circres welcomes submissions for not one, but two upcoming compendia. Click the link for more details: ahajrnls.org/3O66En5
