In patients considered too high risk for a redo surgery, placing a transcatheter aortic valve inside a failed mitral valve (valve-in-valve) demonstrated a high rate of technical success and a low rate of in-hospital mortality, with symptoms improving during follow-up. "Given the low procedural volumes, referral to experienced centres or proctor support may help maintain expertise, while complex ViMAC [valve-in-mitral annular calcification] procedures may be best undertaken in specialised centres," the authors wrote. mdsc.pe/4dXj1z3

Starting in 1 HOUR ➡️ mdsc.pe/4zMwOAG Master new evidence in hypertension care. Join leading expert faculty to elevate your clinical practice. 📅 Today ⏰ 9:00am ET #Hypertension #Cardiology #ISH2026

The government says it can fund the uplift without trade-offs, but the BMA and UNISON warn it risks driving staff from the NHS. mdsc.pe/4eRsE2q

Moderate-to-vigorous walking or other types of physical activity may improve retinal health, according to a large population study using a national database from the United Kingdom. Researchers found people who exercised more intensely appeared to gain more protection against retinal thinning, a hallmark of age-related macular degeneration. mdsc.pe/4z1N4xO

Among non-hospitalised adults, those with physician-diagnosed long COVID had a 14% higher risk of developing incident hypertension than those without long COVID, pointing to the need for closer heart health follow‑up and routine blood pressure monitoring in those with lasting post‑COVID complaints. mdsc.pe/4zKOTPL

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Explore novel strategies for anemia management in patients on dialysis. Review emerging treatment approaches, practical clinical considerations, and ways to individualize care for better outcomes. 🔗 mdsc.pe/4ybNi4L

Every doctor can get bogged down with an endless daily to-do list consisting of everything from pre-authorizations and prescription refill requests to handling in-box messages from the patient portal, and endless electronic health record tasks. These critical (but often invisible) tasks done “behind the scenes” usually take place before patients arrive in the early hours of the morning or at home late into the night — and are drivers of both burnout and exhaustion, with much of this non-patient work spilling into weekend and weeknight hours. mdsc.pe/47CtfkL

Nearly half of the individuals who were drinking when they started using GLP-1 receptor agonists (RAs) reported drinking less within 3 months, with higher odds among those who screened positive for potentially unhealthy past-year alcohol use, US survey data showed. mdsc.pe/4zIfUTM

A nonprofit physicians’ group has sued to force withdrawal of the 2025-2030 Dietary Guidelines for Americans, alleging the process violated federal administrative law. The Physicians Committee for Responsible Medicine filed its complaint in US District Court in Washington, DC, contending that the guidelines were written by a committee with conflicts of interest and little transparency. mdsc.pe/4i63sq1

A prospective registry finds no evidence of increased birth defect risk with dupilumab exposure, although researchers acknowledge that more data are needed. mdsc.pe/4stqRqg

A quality improvement project nearly quintupled the rate of children receiving evidence-based, shorter courses of antibiotics for pneumonia and sinus infections, cutting unnecessary drug exposure without increasing treatment failures, according to the researchers. Research increasingly shows shorter courses of antibiotics — 3-5 days for community-acquired pneumonia and 5-7 days for acute bacterial rhinosinusitis — are safe in children. But clinical adoption has lagged, leaving kids exposed to 10-day regimens that elevate risks for antibiotic resistance, adverse drug side effects, and unnecessary costs. The new study, published in Pediatrics, demonstrates that combining EHR modifications and peer comparison data with frontline clinician champions can establish shorter antibiotic durations as standard care. mdsc.pe/4elyvwM

A meta-analysis found that structured obesity management training programs for healthcare professionals (HCPs), defined by clear learning objectives and curricula, were significantly associated with improved HCP competencies — especially confidence. Only the longer programs (≥ 4 hours) were associated with a significant improvement. mdsc.pe/3U5tRMH

Explore how clinical metagenomic sequencing can support infectious disease diagnosis when conventional testing falls short. Review practical considerations for test implementation, interpretation, and integration into clinical care. 🔗 mdsc.pe/4yt5g3c

The use of cholesterol-lowering statins was associated with a 15% lower risk of developing open-angle glaucoma at 5 years and with a substantially reduced need for laser or surgery in patients who already had the condition. The associations held up, although somewhat weaker, at 10 years, and were seen with drugs such as atorvastatin and rosuvastatin. mdsc.pe/3W0mgzp

Occupational exposure to specific solvents is linked to increased odds of Parkinson’s disease (PD), with the risk increasing as the number of solvent types rise. In a cross-sectional analysis of more than 31,000 participants, several solvents used in industrial cleaning and manufacturing were associated with higher odds of PD. The strongest associations involved trichloroethylene (TCE), kerosene, and carbon tetrachloride, with significant links also found for mineral spirits, methyl ethyl ketone (butanone), toluene, and jet fuel. Each additional solvent type reported was associated with 17% higher odds of PD. Tap the link to read more on the analysis: mdsc.pe/4e9IvJt

Protein restriction, rather than higher-protein intake, could improve metabolic health in older adults and extend both healthy life expectancy and overall lifespan. This is the conclusion reached by Bailey Knopf, researcher, and Dudley Lamming, PhD, from the University of Wisconsin-Madison, in Cell Press Blue. In their review, the researchers examined published studies on protein restriction and identified six effects of reduced protein intake, along with the molecular mechanisms that may promote healthy aging. These benefits appear to be driven primarily by the restriction of specific amino acids, particularly methionine, leucine, isoleucine, and valine. mdsc.pe/4iZme4w

A Canadian student reflects on how patients are shaping her approach to care and questions if a strained healthcare system will allow her time to truly listen. mdsc.pe/4dTfGku