Annie M Goettemoeller (@AMGoettem) header
Annie M Goettemoeller (@AMGoettem) profile picture

⚡️Postdoc @ Soltesz Lab.

Stanford, CA
Joined October 2019
Photo by Annie M Goettemoeller (@AMGoettem)Photo by Annie M Goettemoeller (@AMGoettem)Photo by Annie M Goettemoeller (@AMGoettem)Photo by Annie M Goettemoeller (@AMGoettem)Photo by Annie M Goettemoeller (@AMGoettem)Photo by Annie M Goettemoeller (@AMGoettem)Photo by Annie M Goettemoeller (@AMGoettem)Photo by Annie M Goettemoeller (@AMGoettem)Photo by Annie M Goettemoeller (@AMGoettem)Photo by Annie M Goettemoeller (@AMGoettem)
Replying to @AMGoettem
This paper (the last major paper of my PhD work) is now out! TLDR; LEC LII PV interneurons are uniquely susceptible to human APP! nature.com/articles/s41467-0… See prior thread for details, but don’t miss the newly added in vivo figure (courtesy of Reviewer request) 😊
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Annie M Goettemoeller retweeted
Postdoc position available-
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I'm hiring a lab tech! If you know any talented college seniors or recent grads who'd enjoy doing cool neuroscience in Baltimore, please encourage them to consider applying: umb.taleo.net/careersection/…
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Annie M Goettemoeller retweeted
Online now: Integrating endocannabinoid signaling, CCK interneurons, and hippocampal circuit dynamics in behaving animals dlvr.it/TKJSbS
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Annie M Goettemoeller retweeted
Prof Liqun Luo from @Stanford will give the Gordon M. Shepherd Lecture 🗣️ on his groundbreaking work: "Wiring Specificity of Neural Circuits!" 🧠 You won’t want to miss this—mark your calendars for April 3! 🗓️ We hope to see you there! See flyer for more 👇
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How does Alzheimer’s begin in the brain? Brain Resilience postdoc Annie Goettemoeller (@AMGoettem) studies how early circuit dysfunction in the entorhinal cortex impacts memory and whether restoring these connections could slow disease progression. brainresilience.stanford.edu…
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Meet Annie Goettemoeller (@AMGoettem), a 2025 Brain Resilience Postdoctoral Scholar! In the Soltesz Lab (@SolteszLab), she investigates how early circuit dysfunction in the entorhinal cortex contributes to Alzheimer’s disease and explores potential recovery strategies.
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From engineering targeted therapies for brain tumors to studying neural resilience in aging, the 2025 Neurosciences Postdoctoral Scholars are exploring bold new questions in neuroscience. Meet the researchers and learn about their innovative projects: neuroscience.stanford.edu/ne…
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Annie M Goettemoeller retweeted
Please consider applying for the 2025 Gordon Conference on Inhibition and the preceding Gordon Research Seminar on Inhibitory Cascades in the CNS.  grc.org/inhibition-in-the-cn……Great lineup
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Annie M Goettemoeller retweeted
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time fluorescence to modulation of innate cell behavior (excitation or inhibition of neurons, induction of cell migration, etc.)? Today we report in Nature a new technology platform that provides a step in that direction: PAGERs, for Programmable Antigen-gated G protein-coupled Engineered Receptors, convert recognition of extracellular soluble or cell-attached antigens into diverse user-selected responses. PAGERs are based on G-protein coupled receptors (GPCRs), which themselves are not structurally modular, but we were able to build in modular antigen gating by fusing an antagonist peptide to the extracellular N-terminal end, and then gating the antagonist with a fused antigen-binding nanobody.  When antigen binds, it sterically interferes with the antagonist, leading to relief of receptor inhibition. Drug or agonist can then turn on PAGER. nature.com/articles/s41586-0…
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Annie M Goettemoeller retweeted
Interested in attending the @GordonConf on Inhibition in the CNS in July 2025, consider applying for this amazing @albanetwork_ @ACNPorg travel grant! Also, the program for the conference is online, thanks to @attila_losonczy & Natalia De Marco Garcia!! grc.org/inhibition-in-the-cn…
📢 With generous support from @ACNPorg, ALBA is offering travel grants to early-career brain science researchers from #underrepresented backgrounds to attend any #neuroscience conference between April 2025-2026. If you earned your last degree within the past 10 years, you’re eligible! Don’t miss out - check the details and apply now! 📅 4 Nov 2024 👉🏽 loom.ly/GDU4-Yk
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Woah…what a wicked cool lab to do a postdoc in!
#SfN We are recruiting multiple postdoc positions in each of our 3 key areas of interest. 👇 Please DM- happy to chat in person @SfNtweets rowlab.org for more information
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Why is the LEC vulnerable in early AD? We show fundamental differences of LEC FS interneurons and their specific susceptibility to hAPP. This results in early circuit hyperexcitability, which is quelled after co-injection of human Tau, but at what cost?... doi.org/10.1101/2023.11.06.5…
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HUGE thank you to everyone involved, notably @MJMRowan for his guidance, and the Rangaraju Lab @rangarajulab, Seyfried Lab @nseyfried1, and Weinshenker Lab @LCneuroscience for their collaborations!
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Annie M Goettemoeller retweeted
Interested in cortical Ndnf interneurons, interneuron connectivity, cortical layer 1 or persistent firing? Now finally out in @CellReports Thanks a lot again to everyone who contributed: @RogierPoorthuis @anna_schroed @_Taysuu & my really supportive supervisor Johannes Letzkus!
Layer 1 NDNF interneurons are specialized top-down master regulators of cortical circuits dlvr.it/T6tPY2
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If I’d do it all again, I would undoubtedly choose to work with Matt 100 times over. Can’t do it all again until I finish the first one, though! Defense on June 7th, 2 PM EST! If anyone would like the zoom link, let me know 😊
Replying to @AMGoettem
Beyond just her fantastic scientific achievements, Annie has been labs 'rock' for the past several years. She always goes out of her way to make everyone feel welcome and has helped foster a great environment for all. Come see her defense on June 7th...
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Annie M Goettemoeller retweeted
Congrats @AMGoettem for winning the Emory neuro-PhD Scientific Achievement Award for 2024!
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