@ASThatte2

UT Austin ‘21 to Ph.D. Student at UPenn • @MJMitchell_Lab @NSF Graduate Research Fellow • Lipid Nanoparticles for Immune Engineering • BlueSky: ASThatte

Joined October 2021
  • Tweets88
  • Following246
  • Followers176
1Media
Ajay Thatte retweeted
Mike Mitchell@MJMitchell_LabJun 4
Excited to announce that @MJMitchell_Lab PhD student @ASThatte2's thesis defense titled “Engineering mRNA lipid nanoparticles to combat inflammatory and autoimmune disease” is tomorrow, June 5th at 2 PM ET! Location: Glandt Forum, @UPennSinghNano Zoom: upenn.zoom.us/j/95017690612
1
1
9
906
Ajay Thatte retweeted
Alex Hamilton@a_hmltnJan 29
Thrilled to share the final installment from my Ph.D. research @MJMitchell_Lab! Featuring high-throughput screening using molecular barcoding, a cancer vaccine model, and new tools to evaluate LNP protein corona formation! Read it in Advanced Materials: doi.org/10.1002/adma.2025143…

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahe...

A high-throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying...

advanced.onlinelibrary.wiley.com
2
7
17
1,128
We will also have two posters by @ASThatte2 on steroid lipid nanoparticles for mRNA autoimmune disease therapeutics and Melgious Ang on photoactivatable lipid nanoparticles! #CRS2025 @CRSScience
1
5
540
Mitchell Lab is off to #CRS2025 to give 8 talks by @Junchao_online @_emilyhan_ @DongyoonKim5 @HannahGeisler_ @ShiQiangqiang @hannahyamagata @hannahsafford_ on mRNA vaccines, lipid nanoparticles, cancer immunotherapy, fetal and maternal health, CNS targeting and more! @CRSScience
2
6
1
30
6,319
Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j3xGs8

Baby Is Healed With World’s First Personalized Gene-Editing Treatment (Published 2025)

The technique used on a 9½-month-old boy with a rare condition has the potential to help people with thousands of other uncommon genetic diseases.

nytimes.com
38
354
94
1,144
534,533
Check out our latest publication in @nanoletters led by @MJMitchell_Lab PhD student and lab softball Coach @hannahsafford_ where we explore tuning LNP elasticity using atomic force microscopy to enhance mRNA LNP delivery to the placenta! Link to article: pubs.acs.org/doi/full/10.102…
12
2
68
5,350
Standing room only for @SwingleKelsey’s seminar on mRNA LNPs to treat pregnancy disorders at @Penn’s Center for Women’s Health hosted by @Marisa_S_B! What a special opportunity to see one of our own from @MJMitchell_Lab give their faculty interview seminar on campus! #proudPI
3
62
2,277
Very excited to share our new work, now on @biorxivpreprint, on specificity of memory in human macrophages biorxiv.org/content/10.1101/… (1/8)

Innate Immune Memory is Stimulus Specific

Innate immune memory (also termed trained immunity) is defined in part by its ability to cross-protect against heterologous pathogens, and can be generated by many different stimuli, suggesting a...

biorxiv.org
5
20
1
97
16,201
Thrilled to share our recent work out today in @Nature on an mRNA therapeutic to treat pre-eclampsia! This work has been a true passion project from my time @pennbioeng in @MJMitchell_Lab, and I’m excited to continue important research in women’s health! nature.com/articles/s41586-0…

Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia

Nature - A platform for mRNA lipid nanoparticle delivery to the placenta to treat pre-eclampsia is shown to improve fetal and maternal health in mice and has potential clinical applications in...

nature.com
20
37
198
14,248
Come check out a killer poster by @hannahyamagata on a new class of aromatic lipid nanoparticles that outperform industry standard mRNA vaccines this morning at 10am at #BMES2024! We also have two posters by @MJMitchell_Lab undergrads Ben Nachod and Sridatta Teerdhala!
Mike Mitchell@MJMitchell_Lab23 Oct 2024
Mitchell Lab is off to Baltimore to give 18 presentations at #BMES2024, including 10 talks on mRNA LNP technology for immunotherapy, vaccines, pregnancy, crossing the blood-brain barrier, and more! We are hiring Postdocs and PhD students, come chat with the team if interested!
4
31
2,755
Emerging strategies for nanomedicine in autoimmunity by @ASThatte2 @MagBillingsley @JilianMelamed @WeissmanLab @MJMitchell_Lab Link: sciencedirect.com/science/ar…
1
2
6
356
Thrilled to share our full special issue on drug delivery tech for autoimmunity therapies in @ADDReditors co-edited with @jdweaverBME @RyanMPearson @GormleyLab! Issue: sciencedirect.com/special-is… Editorial led by @ASThatte2: sciencedirect.com/science/ar… Amazing contributions including:
2
12
1
71
3,912
Thankful to @NICHD_NIH for awarding us a new R01 grant on our mRNA lipid nanoparticle pregnancy research led by @SwingleKelsey @hannahsafford_ @HannahGeisler_! We are recruiting postdocs and PhD students in women's health and nanotech, contact us via email or at #BMES2024!
9
11
1
131
5,357
Ajay Thatte retweeted
Sneha Rao@sneha_arao19 Jul 2024
Could *Notch* have had a better time at my first @GordonConf! Thanks to past & future GRS chairs @ishujain4695 @hematolinie @ASThatte2 & Marlene for fostering such a fun & supportive community. Grateful to be heading home (amidst the travel chaos) with new ideas & new friends. ❤️
4
1
20
1,206
Super excited to share our latest in Journal of Controlled Release @JCRnEDITORS led by @MJMitchell_Lab PhD student Hannah Geisler @HannahGeisler_ on antibody-conjugated LNP tech for targeted RNA delivery to the placenta! Link: sciencedirect.com/science/ar…
4
10
3
82
6,223
Check out our latest in ACS Nano @acsnano led by @MJMitchell_Lab PhD student Alex Hamilton @a_hmltn on high-throughput in vivo screening to identify LNPs tailored for local and systemic delivery for mRNA vaccines + cancer immunotherapy applications! Link: pubs.acs.org/doi/full/10.102…
3
10
1
86
6,981
Super excited to announce that @MJMitchell_Lab MD PhD student Rohan Palanki @rohan_palanki 's thesis defense titled "Ionizable lipid nanoparticles for in utero gene editing of congenital disease" is this Wednesday at 1PM! Link to location and Zoom: bit.ly/49jPUS5
1
4
2
50
7,695
Check out our latest in Advanced Materials @AdvSciNews led by @MJMitchell_Lab PhD student Ann Metzloff on antigen presenting cell-mimetic lipid nanoparticles for rapid mRNA CAR T cell cancer immunotherapy! Free access: onlinelibrary.wiley.com/doi/… @Penn story: blog.seas.upenn.edu/accelera…
3
11
1
78
5,150
Check out our latest in Advanced Functional Materials @AdvSciNews led by @MJMitchell_Lab PhD student Alvin Mukalel @AlvMukalel on new oxidized mRNA lipid nanoparticle tech for making CAR monocytes in the body for cancer immunotherapy! Free access: onlinelibrary.wiley.com/doi/…
3
8
85
5,127
Congratulations to Sonja Schrepfer and the team at Sana for curing a nonhuman primate with allogeneic islets without requiring immunosuppression! cell.com/cell-stem-cell/full…

Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immuno...

Schrepfer and colleagues engineered hypoimmune (B2M−/−, CIITA−/−, CD47+) primary rhesus macaque pseudo-islets. They were transplanted into a fully allogeneic, immunocompetent, diabetic, and insulin...

cell.com
4
14
1
74
6,648
Load more