Chromosome biology enthusiast | Fascinated with life cycles of tiny organisms | Novice birdwatcher
Bengaluru, India
Joined January 2020
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Exciting PhD project ✅
Wonderful PI ✅
Satisfying PhD journey ✅
I am extremely happy to share the accomplishment of a major milestone 😃
Our work highlighting the essentiality of RecN activity for long distance homology search is out!!
A huge thanks to @dnarepairlab 🤗
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Afroze Chimthanawala, PhD retweeted
Peeking through blue skies to share our pre-print, from my postdoc work in the Grotjahn Lab :D @nani_grotjahn
We ask how mtDNA replication is coordinated with mitochondrial fission across membranes.
🧵
biorxiv.org/content/10.64898…
Afroze Chimthanawala, PhD retweeted
How do transcription factors (TFs) that recognize the same DNA motif end up binding different places in the genome? 🧬
We're excited to show you how we tackle this question in our new bioRxiv pre-print!
doi.org/10.64898/2026.04.27.…
Afroze Chimthanawala, PhD retweeted
Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
Afroze Chimthanawala, PhD retweeted
Online Now: Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles dlvr.it/TS8WyV
Afroze Chimthanawala, PhD retweeted
We worked with @janetiwasa to realize our visualization vision with @jclandoni of how mitochondrial pearling redistributes mitochondrial DNA containing nucleoids. Super fun! Couldn’t have done any of this without support from @HFSP and @ERC_Research
Afroze Chimthanawala, PhD retweeted
So happy to see this study “in print”, being part of this discovery has been a delight and it’s great to hear different perspectives on it’s implications
In a new Science study, researchers describe how dynamic and reversible mitochondrial membrane constrictions, called “pearling,” spatially organize mtDNA molecules.
The findings reveal a mechanistic link between mitochondrial membrane remodeling and mtDNA biology.
📄: scim.ag/4bW70JD
#SciencePerspective: scim.ag/4mhEOV1
Afroze Chimthanawala, PhD retweeted
One of the finest piece of science journalism; today in print edition of @the_hindu. Based on amazing work of @stpalli and brilliant discoveries from a scientist couple.. science rediscovered and so well written thehindu.com/society/jeewanu…
Afroze Chimthanawala, PhD retweeted
Online now: A new strategy to stabilize gene circuits dlvr.it/TRYv7w
Afroze Chimthanawala, PhD retweeted
Unstructured transcription factor interactions enable emergent specificity | @ScienceMagazine science.org/doi/10.1126/scie…
Afroze Chimthanawala, PhD retweeted
Some molecular machines, like ribosomes, persist for long periods in cells
Could molecular aging of ribosomes shape how proteins are made?
In our preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10)
biorxiv.org/content/10.64898…
Afroze Chimthanawala, PhD retweeted
Structured domain drives filamentation and condensation, and the disordered region inhibits them!
A super important study connectig condensate ultrastructure (through cryo-ET) to cellular function.
nature.com/articles/s41594-0…
Afroze Chimthanawala, PhD retweeted
(1/8) Still wondering how low complexity intrinsically disordered regions (IDRs) guide transcription factors (TFs) to bind in genomes? Previous studies on sequence grammars; our new @MolCell paper takes the next step: de novo design of functional TF IDRs!
cell.com/molecular-cell/full…
Afroze Chimthanawala, PhD retweeted
Bidirectional promoters in Escherichia coli: regulatory rules and implications for gene expression noise academic.oup.com/nar/article…
Afroze Chimthanawala, PhD retweeted
Density transitions in the regulation of transcription: Molecular Cell cell.com/molecular-cell/full…
Afroze Chimthanawala, PhD retweeted
A very enjoyable collaborative writing project with Sebastian Deindl (who suggested it in the first place), Laura Muras, Koushik Sreenivasa, Jagadish Hazra, John van Noort, and Chirlmin Joo.
Afroze Chimthanawala, PhD retweeted
🌟Dr Anjana Badrinarayanan & Dr Deepa Agashe, Associate Professors @NCBS_Bangalore were invited to the #RepublicDay2026 At-Home Reception hosted by the Hon’ble President of India @rashtrapatibhvn
🌟We are honoured to see our faculty recognised through this prestigious invitation!
Afroze Chimthanawala, PhD retweeted
🏆Congratulations to Dr Anjana Badrinarayanan, Associate Professor @ncbs_bangalore, on being elected as a Fellow of the Indian Academy of Sciences!
ias.ac.in/application/Fellow…
@IAScBng @anjbadri @TIFRScience
Afroze Chimthanawala, PhD retweeted
How do cells deal with damage to their DNA?
Dr. Anjana Badrinarayanan, Infosys Prize 2025 laureate in Life Sciences, takes the stage to share her research on how cells find and fix breaks in DNA. Using microscopy and experiments that follow these processes as they happen, her research helps explain how cells keep their genetic material in order.
Intricate lab work that answers some very basic and important questions about how life functions.
#infosysprize #infosysprize2025 #lifesciences #cellbiology #dnarepair #winnerssymposium2025 #livefromthesymposium
Afroze Chimthanawala, PhD retweeted
How does Mycobacterium tuberculosis pack its massive genome while selectively silencing specific genes?
The answer is a dynamic physical process: Sequence-dependent co-condensation.
Our new work in provides insights into the mechanism! 🧵👇
academic.oup.com/nar/article…
Afroze Chimthanawala, PhD retweeted
The Infosys Prize 2025 in Life Sciences is awarded to Dr. Anjana Badrinarayanan, Associate Professor at the National Centre for Biological Sciences, Bangalore.
Her research on genome maintenance and DNA repair explains how cells protect and recover their genetic material.
Dr. Badrinarayanan’s studies help us understand the essential processes that keep living systems stable and healthy.
@anjbadri @NCBS_Bangalore
#infosysprize #infosyssciencefoundation #lifesciences #genomeresearch #DNArepair #NCBS #scientificinnovation #biology
