Interventional cardiologist; cell-therapy founder; learning & investing in digital health. Sprinter. Read more at https://xitter.cf/t.co/EgxaKTQHOP
Joined October 2008
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Dr. Alan Heldman retweeted
Norm Macdonald was Conan’s favorite guest. So here is the greatest joke in late night
Wait for the data before attempting to explain the findings. Seems kinda obvious but maybe I’m old fashioned.
My suggestion to everyone speculating is wait for the full results, not just of HORIZON but the other trials. Then send the preponderance of evidence to the jury to decide on the Lp(a) Hypothesis. We really need to know its (patho)physiological role- why does nearly every human have circulating Lp(a)? And why does only human Lp(a) carry OxPL?. We should be grateful so much investment is ongoing to find out what it means to humanity.
Great thread and quite right to acknowledge that Jerry Fleg knows more about exercise than just about anyone. And to make the point — though I often think and write about exercise among committed masters athletes, those who benefit the most are people who go from zero to *some* exercise.
Exercise Training in High-Risk Populations: A Scientific Statement From the American Heart Association: @CircAHA @bradleymaronmd
🥸 After my PhD, I once interviewed to work at extramural office at the NHLBI and met Dr Fleg; great thinker who wrote many statements and research papers to advance the field. More than 50 years of contribution - very very inspiring! @DEF_gericard
😱 Bravo @CircAHA - Summary
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I love grilled steak. Is it bad for me? My honest answer is that I don't know for sure. But I am thinking about what it would take to find out. 🥩
Individual Genes × exposures. Enormous effect. Completely invisible unless you have both pieces of data.
Population-scale genome x exposome. Large libraries of data. This is what it will take to find out. It will be incredibly valuable.
Who should govern those libraries of your health data?
I think you should.
1/ A friend of mine has ruptured tendons again and again over a decade on a statin. He wants to know: did the drug do it? It's one of the hardest questions in medicine - and a clean lesson in why "it happened while you were on the drug" is not the same as "the drug caused it." 🧵
1/ I prescribed statins to thousands of patients over my career as a cardiologist. I believe the evidence: they reduce heart attacks and strokes in people at risk. But I think we've been giving an average answer to a deeply personal question. A thread on the answers I never had. 🧵
