Computational Biologist @HiCinNYC
Manhattan, NY
Joined August 2018
- Tweets42
- Following232
- Followers95
- Likes103
Alexander retweeted
Respiratory failure is a leading cause of death in AML.
It begins when leukemia infiltrates the lung. Almost nothing was known about what happens locally.
We looked.
🧵 @NatImmunol
🔗 nature.com/articles/s41590-0…
Alexander retweeted
Check it out and register for free! Always incredibly fun and impactful science and an amazing panel of speakers! Very glad to participate as an organizer this year #chromatin #cancer #4DNucleome
We’re back! Registration is NOW OPEN for the 6th Annual Meeting on Advances in Nuclear Topology & 3D Chromatin Architecture in Cancer. Don’t miss insights from leading experts in the field. Join us online on Nov 25, 2025—register for free: bit.ly/chromatin-2025#chroma…
Alexander retweeted
Cohesin is essential for maintaining structural loops but less so for regulatory loops and transcription. Is cohesin actually required for the establishment of loops and transcriptional activation?🧵bit.ly/4hXremH
Alexander retweeted
🚀🚀🚀 Feeling beyond grateful and thrilled to share that our lab has been awarded the FIS grant from the Italian Ministry of Education!
📢 To all chromatin lovers: our lab will soon be opening up several positions! Contact me directly if interested!
opentalk.iit.it/le-ricercatr…
Alexander retweeted
GoT-ChA!
I am thrilled to announce that our paper "Mapping Genotypes to Chromatin Accessibility Profiles in Single Cells" is now out in @Nature !!
👩🔬👨🔬🧬If you want to link somatic mutations to epigenetic changes directly in patient samples:
nature.com/articles/s41586-0…
👇🧵
Excited for our latest work biorxiv.org/content/10.1101/… with @efapostolou29 & @artsinyc. We study the role of 3D hubs & enhancer rewiring in early developmental lineages & introduce 3D-HiChAT machine learning approach to nominate impactful enhancers for gene regulation.
i. Multi-connectivity and gene expression: A 1-to-many relationship?
ii. Gene co-regulation in and out of the 3D hubs.
iii. Can enhancer rewiring dictate cell type specificity?
iv. What happens if we code all these questions in a ML?
Bonus question: How applicable is this ML?
Alexander retweeted
Happy to see our own @VarvaraParask representing blood cancer at @Fusion_Conf "Animal Models of Cancer"! Dont forget: Leukemia is a cancer and it has it's microenvironment 😀! Thanks @KevinHaigisLab & @SageJulien for inviting Varvara! #AifantisLab @NYUGSOM_Path #CancerResearch
Alexander retweeted
C.Origami, a machine learning model for cell type-specific chromatin architecture prediction and discovery of putative regulatory elements! Developed by our student @tan_jimin in collaboration with @BoXia7. @NatureBiotech @4DNucleome @EpigenChromatin @epigen_papers
Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening go.nature.com/3GR6nRX
Alexander retweeted
Our C.Origami paper is accepted at Nature Biotechnology. Special thanks to @BoXia7, @artsinyc and all my collaborators for their invaluable guidance and support along the way. It has been an amazing journey!
Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening go.nature.com/3GR6nRX
Alexander retweeted
Slavi et al. @NeuroCellPress CyclinD2-mediated regulation of neurogenic output from the retinal cil... sciencedirect.com/science/ar…. Extremely proud to have worked in this seminal study led by Nefeli Slavi. Congratulations to all the participants. #AcademicTwitter
Alexander retweeted
#postdoc position available in my lab!
Exciting opportunity to work on the role of #ncRNAs and #ChromatinArchitecture in #StemCells @IIT.
This position is fully supported by the ECF fellowship from the @HumanTechnopole and will be based in Genova (Italy). nature.com/naturecareers/job…
Alexander retweeted
New preprint from the lab!
Led by @IMPRS_GS PhD students Shu Zhang and Nadine Ubelmesser and supported by @dr_barbieri_mar for modeling, we found selective dependency of enhancer-promoter loops on RNAPII using #MicroC. Our work assigns RNAPs with a clear role in #3Dgenome folding
Alexander retweeted
Our new study: C.Origami predicts cell type-specific 3D chromatin structures 🧬 and enables genome wide screening for crucial factors. It has been an honor working with @BoXia7 and @artsinyc in this exciting project!
Check out our website and a live demo!
tanjimin.github.io/c.origami…
Alexander retweeted
Very excited to present our latest work with @tan_jimin and @BoXia7: using machine learning to predict cell type-specific chromatin architecture and enable in silico perturbation studies! @nyugrossman @Perlmutter_CC biorxiv.org/content/10.1101/…
Alexander retweeted
NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization @nyugrossman biorxiv.org/content/10.1101/…
Alexander retweeted
A wonderful paper from the twitter-less Nefeli Slavi @LadyGlaucoma and the @drcarolmason lab, linking gene expression in the CMZ with the establishment of the binocular circuit and depth perception.
biorxiv.org/content/10.1101/…
