@Alihuma89
 Berlin
Joined January 2012
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🚨 A novel role for microRNAs 👉 they control mammalian sex determination 🧐 Find out in our new pre-print: “Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster” biorxiv.org/content/10.1101/… A detailed thread below 🧵
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Ever wondered how bats develop wings from their hands? 🦇✨ Check out our new preprint and the thread below! 🤓 👏Big applause to our amazing first authors @M_Schindler_ and @ChrisFeregrino and thanks to all our co-authors for their help! 🥂 biorxiv.org/content/10.1101/…
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Alicia Hurtado retweeted
Fany Martinez Real@RealFany8 Oct 2024
PhD position available in my lab - Fully funded! Please, apply or RT! 👩‍🔬🐭🧫
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Magnificent stripy eye work from @Alihuma89 and colleagues showing everyone's second favourite gene, Sox9, is needed in the stem cells that maintain the corneal surface. biorxiv.org/content/10.1101/… @preLights @the_Node
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My thoughts on a landmark paper from @Alihuma89 @Dariloops et al. A brilliant contribution to the field of #sexdetermination opening up many more avenues of research ahead👏 @TheScientistLLC 👇 Deleting a MicroRNA Cluster Reversed Biological Sex in Mice the-scientist.com/deleting-a…

Deleting a MicroRNA Cluster Reversed Biological Sex in Mice | The Scientist

Removing microRNA that caused conversion of male mice embryos into female sheds light on key noncoding elements in sex determination.

the-scientist.com
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Alicia Hurtado retweeted
CSIC
@CSIC14 Jun 2024
🧬Identifican un grupo de pequeñas moléculas necesarias para la determinación del sexo en mamíferos. Investigadores del @CABD_UPO_CSIC y la @CanalUGR demuestran por primera vez el papel determinante que juegan los microARNs en este proceso. 👉bit.ly/3RwhhkX
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The final version of our article is available We report a novel role for microRNAs in sex determination. A nice collaboration with Barrionuevo and Jimenez lab, and led by @Alihuma89 @IreneMota @Milape42 👏👏 @MDC_Berlin @BIMSB_MDC @CABD_UPO_CSIC nature.com/articles/s41467-0…

Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster

Nature Communications - The cluster miR-17~92 modulates the expression of genes networks and signalling pathways to ensure proper Sry expression timing and subsequent testis differentiation, an...

nature.com
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How did skates evolve their characteristics wing-like fins?🧚 Find clues in our last paper @Nature A great team effort w @jjtenagu @rdacemel @Ferdix @tetsuyanakamu @tzinicris_p @elcalmus1 @DanRokhsar Part of the rich legacy of the late @jlgomska nature.com/articles/s41586-0…

The little skate genome and the evolutionary emergence of wing-like fins

Nature - Skate-specific changes in the epigenome and its three-dimensional organization contributed to the evolution of the batoid fin morphology.

nature.com
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12/13 But this state of sex ambiguity is rapidly resolved towards the female fate, with the initiation of germ cell meiosis, an early sign of ovarian differentiation (OCT4-, SYCP3+)
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13/13 In summary, we reveal a novel role for the miR-17~92 cluster and for miRNAs in controlling the early steps of mammalian #sexdetermination. You can find more details in the manuscript. Get in touch with us with any potential question!!
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