@Altmaniacs

Synthetic organic, organometallic, and medicinal chemistries, fluorophilic like you wouldn't believe

 West Lafayette, IN
altmaniacs.com/
Joined December 2014
  • Tweets339
  • Following517
  • Followers630
102Media
Considering the abundance of reactions for generating cyclohexan(en)ones with precise control of substituents (e.g. a-, b-, and g-functionalization, annulation, and Birch reactions), this new deoxytrifluoromethylation/aromatization strategy
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now enables access to a wide spectrum of Ar–CF3 products that are difficult, expensive, and/or impossible to access by current synthetic methods.
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In ongoing work, the strategy also enables access other fluoroalkyl groups, and mild conditions for aromatization have already been established that should further improve the scope of accessible Ar–RF products. Stay tuned for future developments.
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Want to become a synthetic physical organic chemist applying modern tools to reaction discovery & catalysis? The Lovinger Lab might be a good fit. We draw inspiration from reactive intermediates as branching points in chemical reaction space to enable new reactivity & selectivity
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Professor Ryan Altman has been named the Steve and Lee Ann Taglienti Chair in Pharmacy. Altman is an internationally recognized scholar, and this honor is a testament to his impactful contributions to academia and research. loom.ly/dcuSF1I @Altmaniacs #pharmacysgiantleap
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Creighton (Chemistry) Alumni, Mark Kearley is hanging up the lab coat and goggles and retiring, and we are assembling a book of student memories. Would you like to contribute a message or some pictures for Mark? Please DM me for a link to the form @creightonchem @CreightonCAS – at West Lafayette, IN
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How would you make this structure? (not saying you actually want to) See how Andrew, Mohan and Mani did it: thieme-connect.de/products/e… – at West Lafayette, IN
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📢 Medicinal Chemistry Postdoc #chempostdoc in New Zealand @otago university. There is still 1 week to apply for a postdoc position in our team developing new #bioorthogonal prodrug strategies. RTs appreciated! otago.taleo.net/careersectio…
The Gamble Lab@gamble_lab24 Oct 2023
Exciting opportunity to join our team as a Postdoc working on Bioorthogonal Prodrug Activation Strategies. This is a 2-year post in Ōtepoti Dunedin on the South Island of New Zealand. otago.taleo.net/careersectio…
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Nursing Pharmacy Education Building groundbreaking at #Purdue today. Thanks to generous support from state legislature and donors, the $160M academic facility will be constructed, to substantially increase @LifeAtPurdue’s contribution to healthcare. Life and Health Sciences moving forward with momentum at Purdue!
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Applying to grad school can be expensive, so this year Purdue Chemistry is paying the application fee for qualifying U.S. citizens or permanent residents applying to our PhD program for Fall 2024 admission. Learn more: bit.ly/24CHMAppOffer
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@Purdue_MCMP is hiring for Faculty Positions in Translational Neuroscience and Chemical Biology careers.purdue.edu/job-invit…
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Applying to grad school can be expensive, so this year Purdue Chemistry is paying the application fee for qualifying U.S. citizens or permanent residents applying to our PhD program for Fall 2024 admission. Learn more: bit.ly/24CHMAppOffer
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It's taken more time than desired, but we're finally getting our group website back in order. altmaniacs.com/
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...and to follow up on the last tweet, here Ryan, Mohammed, and Laura add aliphatic alcohols across difluorinated alkenes under photoredox conditions. In this reaction, an uncommonly exploited diselenide co-catalyst helped avoid elimination of fluoride pubs.rsc.org/en/content/arti…

A diselenide additive enables photocatalytic hydroalkoxylation of gem-difluoroalkenes†

A photocatalytic hydroalkoxylation reaction enables the coupling of aliphatic alcohols with gem-difluoroalkenes, expanding the scope of accessible α,α-difl

pubs.rsc.org
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Apologies for being a bit late on getting this one posted. Here's a recent one from Jacob and colleagues: pubs.acs.org/doi/full/10.102…

General Co-catalytic Hydrothiolation of gem-Difluoroalkenes

Abstract. Regioselective functionalization of gem-difluoroalkenes enables convergent late-stage access to fluorinated functional groups, though most functi

pubs.acs.org
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@JOC_OL
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Notably, the reaction exploits an underutilized aniline-derived co-catalyst to generate the difluorinated product, which contrasts related base-mediated photocatalytic reactions that undergo net C–F functionalization to deliver α-fluorovinylthioethers.
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Instead, we developed a photocatalytic hydrothiolation of gem-difluoroalkenes that enables access to a broad spectrum of α,α-difluoroalkylthioethers.
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Most functionalization reactions of gem-difluorinated alkenes proceed through defluorinative functionalization processes that deliver mono-fluorovinyl product, and few reactions undergo net hydrofunctionalization to generate difluorinated products.
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