Exciting news! 📢 Our latest paper in @BBAjournals (BBA Biomembranes) explores how the supramolecular organization of LPS influences Factor XII activation. New insights into the link between bacterial components and coagulation!
sciencedirect.com/science/ar… – at Portland, OR
André Lira retweeted
“We’re optimistic that this approach could prevent dangerous clots in sepsis patients without increasing their risk of bleeding." #OHSUResearch news.ohsu.edu/2025/01/17/sep…
André Lira retweeted
Researchers at @OHSUNews have uncovered how a molecule found on certain bacteria may drive blood clotting in sepsis, a life-threatening condition that causes about 8 million deaths per year.
#OHSUResearch: bit.ly/4alOasW
André Lira retweeted
Congrats @AndLLira on your @jbiolchem paper “The physicochemical properties of lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation” #lps #sepsis #thrombosis sciencedirect.com/science/ar…
Thrilled to share that my paper has been accepted for publication in the @jbiolchem ! Grateful for the support and collaboration of everyone involved—thank you all!
#lps #sepsis #coagulation #contactpathway #jbc #ohsu
jbc.org/article/S0021-9258%2…
Thrilled to see our review on FXI in this month’s edition of @SemThrombHemost. #thrombosis #hemostasis #FXI
thieme-connect.com/products/…
André Lira retweeted
New in JBC press: "Scientists were able to determine the kinetic signature of inhibitors that act at single steps in the pathway and delineate the full mechanism of action of known and novel C3 inhibitors."
Learn more:
jbc.org/article/S0021-9258(2…
Thanks #ISTH2024 for the opportunity to present this work. – at Khlong Toei, Thailand
It was a fantastic opportunity to present about molecular biophysics applied to hemostasis at #ISTH2024. Thanks so much for this great opportunity. – at Bangkok, Thailand
Poster Presentation at #BPS2024. #coagulation #contactsystem #lipopolysaccharides #sepsis #thromboinflammation – at Philadelphia, PA
André Lira retweeted
Your academic CV is NOT linked to your ability to make big discoveries.
▫️
1. Andre Geim, a co-discoverer of graphene, wrote in his Nobel Lecture article:
- “So, at the age of 33 and with an h index of 1 (latest papers not yet published), I entered the Western job market for postdocs.”
2. Albert Einstein searched for a teaching position for two years. He had to accept a position at a Patent Office, where in a single year he wrote the four papers that completely revolutionized #science (the photoelectric effect, Brownian motion, special relativity, and E=mc2).
- Only few years later, he finally secured his first academic position as lecturer at the University of Bern.
▫️
Other examples include Peter Ratcliffe and Frances Arnold, who won Nobel Prizes for the discoveries they made as young PIs in newly established labs. And many others.
▫️
So, let us all keep in mind that:
1. Big discoveries are often unforeseen. They emerge from random and risky research (e.g. graphene was a tiny side project!). Make sure you have such projects in your lab.
2. Most truly impactful discoveries did not require high h-indices, excessive funding or a high-IF journal.
3. Rejection of your proposal does NOT mean it proposes bad science. Such rejections represent the opinion of one person who has a rather subjective idea of what ‘good science’ means.
4. For younger people, it’s easier to do risky research. Locking them to unnecessarily complex tenure requirements makes such discoveries unlikely.
▫️
A strong scientist is not defined by high “academic metrics”.
It is the ONE who proposes risky endeavors outside the conventional boundaries.
Who sees risk as an opportunity to make discoveries.
And who is constantly seeking out these risks in the lab.
#AcademicTwitter #AcademicChatter
First talk in an international conference! I am glad for this amazing opportunity. #ISTH2023
#sepsis #lps #coagulation
André Lira retweeted
@SemThrombHemost eFirst now online: "Substrates, Cofactors, and Cellular Targets of Coagulation Factor XIa" by @AndLLira @OHSUSOM @OHSU_BME #hemostasis #thrombosis #FXI #f11 thieme-connect.com/DOI/DOI?1…
I am pleased to share with you our recent paper review published in @SemThrombHemost on Substrates, Cofactors, and Cellular Targets of Coagulation Factor XIa
thieme-connect.com/products/…
Very nice work effort @plateletwalker
André Lira retweeted
Please check out and support Owen McCarty Team @plateletwalker and the @American_Heart @AHAScience @OHSUSOM @OHSU_BME #thrombosis #Cardiovascular now.ohsu.edu/member/post/aba…
André Lira retweeted
We know about the heart-brain and brain-gut interactive axis. Now there's the liver-heart:
A clotting factor (FXI) made in the liver protects the heart (unexpectedly) from failure
science.org/doi/10.1126/scie…
science.org/doi/10.1126/scie…

























