A new study found that large language models generally followed Choosing Wisely recommendations, with low rates of overuse and underuse. In an editorial, Deborah Korenstein, MD, and Daniel J. Morgan, MD, MS, argue that evaluations of clinical #AI should measure not only diagnostic accuracy but also its ability to reduce unnecessary care, avoid harm, and improve patient outcomes. bit.ly/4icLDWo

A new commentary examines the FDA’s recent approval of bemotrizinol, the first new sunscreen ingredient added to the U.S. monograph in 27 years. The authors argue that this approval is an important step toward modernizing U.S. sunscreens, which currently offer fewer UV filter options than those available in Europe. Expanded access to modern UV filters could benefit patients at increased risk of skin cancer, photosensitivity, and sun-related skin damage. Read here: bit.ly/4zOfagc

In 225 clinical scenarios based on Choosing Wisely recommendations, LLMs aligned with evidence-based guidance, recommending potentially unnecessary tests or treatments in just 5.4% of responses and rarely withholding appropriate care. Researchers found that LLMs were more likely to suggest unnecessary care in scenarios where clinical guidance is debated or symptoms could reasonably justify additional testing.   These findings suggest that commercial LLMs generally align with evidence-based principles of medical restraint while highlighting opportunities for targeted improvement. bit.ly/3UevlnQ @deanarielmd @ClalitHealth @GuyLaban @bengurionu

A new editorial highlights #IronDeficiency in women as a major but often overlooked public health concern. The authors point to growing evidence linking maternal iron status during early pregnancy to offspring neurodevelopmental outcomes and call for routine ferritin measurement, greater attention to heavy menstrual bleeding, and earlier treatment of iron deficiency before conception. bit.ly/4sbNRJX

In a new episode of Annals on Call, Dr. Centor @medrants discusses the use of carvedilol in patients with cirrhosis with Drs. Kueiyu Joshua Lin and Tracey G. Simon. bit.ly/47rfIMX

Universal hepatitis B vaccination at birth remains the most effective strategy for preventing childhood HBV infection, according to a new modeling study. Researchers projected that delaying #vaccination from birth to 2 months could increase chronic hepatitis B infections by 19%, while a shared decision-making approach could increase chronic infections by 83% compared with the current universal birth-dose strategy. Read here: bit.ly/4yx3wFg

A new issue of Annals of Internal Medicine is online now. Read the latest at bit.ly/4rhjz7F

ICYMI: A population-based cohort study found that pregnant people who used benzodiazepines during the first trimester were not at a substantially increased risk of having a baby with major birth defects. bit.ly/4sgjEK3

Check out ACP’s Career Connection to view jobs, upload your CV, and access career tools and resources to advance or jumpstart your career in internal medicine: bit.ly/3NG62b3

Did you know that Annals offers informative podcasts, compelling videos, insightful medical humanities, and more? Discover your favorite Annals multimedia feature today and earn FREE CME credit and MOC points from designated features: bit.ly/43y6so8

Listen to Annals Editor in Chief, Christine Laine, MD, MPH, discuss highlights from the latest issue articles in the Annals Latest Highlights podcast. bit.ly/4saGKSk

In a new Annals #BeyondTheGuidelines feature, a primary care physician and an obstetrics and gynecology physician debate how they would screen a healthy 26-year-old woman for #CervicalCancer.   The discussion examines recommendations from the American Cancer Society, the Women's Preventive Services Initiative, and the draft U.S. Preventive Services Task Force guidelines, which all generally favor primary HPV testing but differ on when screening should begin, preferred testing approaches for younger women, and the role of self-collected HPV testing. bit.ly/4hJL2fL

ICYMI: A national analysis of medical #cannabis registry data found that the number of Americans registered to use medical cannabis increased from about 747,000 in 2016 to about 3.9 million in 2024. Patient enrollment often declined after states legalized recreational cannabis, suggesting some people may obtain cannabis outside medical programs. bit.ly/4yQF0jz

State of Louisiana v Food and Drug Administration (Louisiana v FDA) seeks to limit expanded access to mifepristone for medical abortion via telemedicine. In a new commentary, S. Sean Tu, JD, PhD, Lewis A. Grossman, JD, PhD, and William B. Feldman, MD, DPhil, MPH, describe how this represents a larger threat to evidence-based decisions of the FDA by allowing judges without the expertise to make decisions on questions of medication safety. Read here: bit.ly/4dETL0k

Medicare beneficiaries taking commonly prescribed medications could see meaningful savings under the Medicare Drug Price Negotiation Program. A new study projects an average annual savings of $685 for beneficiaries in stand-alone Part D plans and $470 for those in #Medicare Advantage drug plans. Patients taking some commonly prescribed medications could see annual out-of-pocket cost reductions of 26% to 49%. Read the report here: bit.ly/4yYMQYn

A new study found that oral #semaglutide for weight management surpassed 100,000 new prescriptions within two months of its January 2026 FDA approval. Despite its rapid uptake, the pill did not replace injectable weight-loss medications. Instead, it appeared to bring new patients into #obesity treatment, increasing overall use of incretin-based therapies. Read here: bit.ly/47fVvcT

A new commentary argues that when data are scarce and health decisions are urgent, simple policy models can often provide more useful insights than highly complex alternatives. The article highlights how thoughtfully designed models can support decision-making by prioritizing transparency and insight over unnecessary complexity. Read here: bit.ly/47Rkfs1

The latest Annals #InTheClinic feature explores the current evidence on screening, prevention, diagnosis, treatment, and practice improvement for delirium. bit.ly/3VHG7U8

In a cohort of 4.2 million Medicaid and commercially insured pregnancies, first-trimester #benzodiazepine use was not associated with a meaningful increase in the risk for major congenital malformations. The findings provide reassuring evidence about the safety of these medications in early pregnancy, while underscoring the need for further research on rare birth defects, longer-term exposure, and other #pregnancy outcomes. bit.ly/4B625jJ