@AntebiLab

Department of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing | Tweets by @episarah87, @KoelschbachJ, @fetzli, by Adam are signed AA.

 Cologne, Germany
age.mpg.de/science/research-laboratories/antebi/research
Joined October 2018
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The full story of our paper, in one thread. Super grateful to everyone who carried this! #Celegans #Splicing #Metabolism #VitaminB12 #Phospholipids #RareDisease @NatureComms @NaturePortfolio
Antebi Lab@AntebiLabAug 10
1/8 🚨 Out now in @NatureComms 🚨 A vitamin mitigates symptoms of a rare genetic disease. Verheij syndrome is caused by mutations in the mRNA splicing factor PUF60. Vitamin B12 restores normal development in our disease model, the worm C. elegans. rdcu.be/fyIgM
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1/8 🚨 Out now in @NatureComms 🚨 A vitamin mitigates symptoms of a rare genetic disease. Verheij syndrome is caused by mutations in the mRNA splicing factor PUF60. Vitamin B12 restores normal development in our disease model, the worm C. elegans. rdcu.be/fyIgM
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8/8 In sum, we identify a metabolic bottleneck underlying PUF60 deficiency and show that vitamin B12 rescues Verheij-like phenotypes. We propose that splicing diseases may be metabolically tractable and will further investigate B12 supplementation as a therapeutic strategy.
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Big thanks to @WenmingAGE, @KoelschbachJ, @MPIAGE, @CECAD_ #Celegans #Splicing #Metabolism #VitaminB12 #Phospholipids #RareDisease #NatureCommunications @NaturePortfolio
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We recently said goodbye to our wonderful PhD-student-turned-postdoc @KlaraSchilling. From C. elegans, mTOR and steroid metabolism to gardening and other new adventures. Your resilience is exemplary and your spirit contagious. We will miss you! 🪱🌿🌼 #Celegans #mTOR
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Last week we said goodbye to one of the founding members of our lab. Birgit joined the lab as a postdoc @MPI_MolGen & rejoined when the lab moved to the @MPIAGE. She did incredible science, served as our lab manager & trained generations of junior scientists. You will be missed!
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🚨Publication @Micropub7n micropublication.org/journal… PoC study by @ypark_bioinfo: deconvolving the C. elegans proteome to organ- & tissue-level ageing trajectories expands the use of single-worm proteomics data as a powerful tool to study dynamic cellular changes during ageing.
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Today we said farewell to our PhD student turned postdoc @BallhysaEugene. The energy in his conversations matched his enthusiasm for science🔬🐟We’ll miss you—and we wish you all the best for the road ahead!
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🥳🎓Congratulations to Maja on an outstanding master’s thesis defense. Your rigor, perseverance, and dedication are exemplary. Excited to see what comes next.🌟#GradLife #MastersDefense
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1/4 Our preprint by @VMartinezMigu3l & Till Popkes van Oepen “Modulation of the RNase P/MRP complex and mitochondrial ribosome enhances cytosolic ribosome coordination and sustains longevity” is now live @biorxivpreprint 📄#agingbiology #ribosome 👉biorxiv.org/content/10.64898…
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3/4 Using C. elegans, we find that loss of the nucleolar regulator, ncl-1/TRIM2-3, disrupts ribosomal balance, leading to proteostasis defects and premature aging. Ribosomal biogenesis becomes uncoordinated, causing imbalanced ribosomal components and translational dysfunction.
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4/4 Perturbing either the mitochondrial ribosome or the RNase P/MRP complex restores ribosomal balance & extends lifespan, suggesting that improving ribosome coordination, rather than reducing overall biogenesis, is a promising avenue to support cellular health in ageing.
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Our tiny market of longevity dreams—lab merch, publications, Flammkillifish and ‘rejuvenation’ tonics—won🥈in the annual window decoration contest!🥇to the Huppertz and Scheiblich labs chasing the Grinch for their data. Backups, people! 💾 #LabLife #AgingResearch #FestiveScience
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