
Hodgkins lymphoma survivor, oncogeneralist, survivorship medicine, Internal Medicine, #survonc, St. Luke’s University Health Network
Chalfont, PA
Joined October 2016
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Anthony Perre MD FACP retweeted
🩸 PATHFINDER 2 is now published in Nature Medicine.
In >35,000 adults ≥50 years old, a blood-based multi-cancer early detection (MCED) test showed:
• Specificity: 99.64%
• PPV: 60.3%
• Cancer detection rate: 0.54%
• Sensitivity: 39.3% across all cancers
• Sensitivity: 69.8% for 12 cancers responsible for ~⅔ of U.S. cancer deaths
• Cancer signal origin accuracy: 91.3%
• 53% of newly detected cancers were stage I–II
Adding MCED to standard screening detected 6.5× more cancers.
The critical question remains: Will earlier detection translate into lower cancer mortality?
That will require randomized trials and longer follow-up.
📄 doi.org/10.1038/s41591-026-0…
@NatureMedicine @OHSUNews @GRAIL
#PATHFINDER2 #MCED @OncoAlert @oncodaily #CancerScreening #EarlyDetection
Anthony Perre MD FACP retweeted
Great work on this updated Cancer-related Fatigue guideline! @ASCO and @Integrativeonc
Management of fatigue for adults with cancer:
Clinicians should recommend exercise, CBT, mindfulness-based programs, and tai chi or qigong to reduce the severity of fatigue during cancer treatment.
@APTAOncology @ACRMCancerRehab
#survonc #survivorship #cancerrehab
ascopubs.org/doi/10.1200/JCO…
Anthony Perre MD FACP retweeted
In case we needed more evidence in 2024.
"The Importance of LDL-C Lowering in Atherosclerotic Cardiovascular Disease Prevention: Lower for Longer is Better"
sciencedirect.com/science/ar…
Anthony Perre MD FACP retweeted
#SGLT2 inhibitor improved outcomes in #Cancer Therapy #cardiotoxicity #CTRCD #cardioonc #cardiometabolic
#SGLT2i shows incremental benefits in addition to other #GDMT
🔻 #HeartFailure, mortality, hospitalization, #Afib #AKI
@JACCJournals
@ACCinTouch @LaheyResearch
More data showing the role of exercise for our patients
👀 Check out what’s popular this week in #JCO:
Randomized Trial of #Exercise and #Nutrition on Chemo Completion and Pathologic Complete Response in Women w #BreastCancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study ➡️ brnw.ch/21wCpw2 #bcsm
Anthony Perre MD FACP retweeted
Super excited to share our paper outlining how we can work together across oncology and cardiology to improve outcomes for patients with cancer and CVD. When Cancer and Cardiovascular Disease Intersect: The Challenge and th... sciencedirect.com/science/ar… @COSAoncology @COSA_Surviv
Wow , fantastic ! Have used urea cream to this point
Hand-foot syndrome is a tough patient experience issue in cancer care. New RCT suggests topical diclofenac markedly reduces incidence/severity of HFS, w/less need to dose-reduce effective chemotherapy! Low cost, high impact #ASCO23 #pallonc #hapc meetings.asco.org/abstracts-…
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Anthony Perre MD FACP retweeted
Hand-foot syndrome is a tough patient experience issue in cancer care. New RCT suggests topical diclofenac markedly reduces incidence/severity of HFS, w/less need to dose-reduce effective chemotherapy! Low cost, high impact #ASCO23 #pallonc #hapc meetings.asco.org/abstracts-…
Anthony Perre MD FACP retweeted
#LaSalleTrack making moves at State Championships:
- Ryan McGinley runs a PR of 4:15.23 to finish 16th in the state
- 4x400 team of Cameron Mehallo, Ryan Perre, Connor Goldfarb and Aidan Christy run a season best of 3:21.91 to qualify for the final!
Anthony Perre MD FACP retweeted
Kobe Bryant is one of the greatest athletes of all time.
In 2016, we got to see why.
Bryant gave a speech at an awards show.
He used the moment to address all athletes.
“We’re not on this stage just because of talent or ability,” Bryant said.
“We’re up here because of 4 am.
“We’re up here because of two-a-days or five-a-days.
“We’re up here because we had a dream and let nothing stand in our way.”
It was the Mamba Mentality on full display.
***
LESSON: You can’t cheat the work
Bryant was an obsessive athlete.
• He’d workout at 4am
• He’d train 3x as much (or more) as others
• He had a ruthlessly competitive mindset
He’s the perfect example of what happens when elite talent and work ethic come together.
The lesson here isn’t to be Kobe Bryant.
• You don’t need to wake up at 3am (sleep is good)
• You don’t need to constantly train (over-training is real)
• You don’t need to be ruthlessly competitive (there’s a dark side)
But whatever your craft, you can’t cheat the work.
There’s a process to becoming great (at anything).
• It requires time, intention and discipline
• It demands an unreasonable commitment
• It’s not for the lukewarm or the faint-hearted
There’s no shortcut to the highest mountains.
***
Follow @TMitrosilis for more content like this.
Anthony Perre MD FACP retweeted
Cigna uses an automated system that allows “medical directors” (doctors employed by @Cigna) to deny a claim in 1.2 seconds without opening the patient’s file.
Please read this, share it, and help us (metaphorically) burn these companies to the ground.
Doctors at a major US insurance company deny tens of thousands of claims a month without even looking at patients’ files.
“We literally click & submit,” a former Cigna doctor told @ProPublica & @Capitol_Forum. “It takes all of 10 seconds to do 50 at a time.”
The inside story 🧵
Anthony Perre MD FACP retweeted
A great start to 2023! Proud to have worked on this scientific statement on cancer related hypertension with my cardio-oncology colleagues. @ICOSociety @AHAMeetings @DukeMedSchool @DukeCancer @escardio @DukeHeartCenter
Anthony Perre MD FACP retweeted
It is critical that current clinical practices for the prevention, diagnosis, and treatment of cardiotoxicity adapt to the evolving landscape of #BreastCancer care. Read the expert analysis to learn more: bit.ly/3wJCBJX @blockthebetas #CardioOnc #CardioTwitter
Anthony Perre MD FACP retweeted
To summarize, my framework for how to stop procrastinating:
(1) Awareness
(2) Deconstruction
(3) Plan Creation
(4) Stake Creation
(5) Action
Follow me @SahilBloom for more.
This will be built out into a procrastination guide. Subscribe to get it! sahilbloom.substack.com






























