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Autophagy Articles

@AutophagyJC

Daily updates on autophagy research. Covering macroautophagy, CMA, mitophagy, lysophagy, pexophagy, ER-phagy, aggrephagy, nucleophagy, and xenophagy.

Joined September 2022
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Hyper-ubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy. doi.org/10.1016/j.jbc.2023.1…
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TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure. doi.org/10.15252/embj.202211…
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure

TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure

The EMBO Journal - Invasive bacteria enter the cytosol of host cells through initial uptake into bacteria‐containing vacuoles (BCVs) and subsequent rupture of the BCV membrane, thereby...

link.springer.com
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TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy. doi.org/10.15252/embj.202211…
TECPR1 is activated by damage‐induced sphingomyelin exposure to mediate noncanonical autophagy

TECPR1 is activated by damage‐induced sphingomyelin exposure to mediate noncanonical autophagy

The EMBO Journal - Cells use noncanonical autophagy, also called conjugation of ATG8 to single membranes (CASM), to label damaged intracellular compartments with ubiquitin‐like ATG8 family...

link.springer.com
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The regulatory role of lipophagy in central nervous system diseases. doi.org/10.1038/s41420-023-0…

The regulatory role of lipophagy in central nervous system diseases

Cell Death Discovery - The regulatory role of lipophagy in central nervous system diseases

nature.com
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Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis. doi.org/10.1038/s41556-023-0…

Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis

Nature Cell Biology - Alkhoury et al. show that the class 3 phosphatidylinositol-3-kinase Vps15 subunit coactivates the circadian clock transcription factor Bmal1–Clock for metabolic...

nature.com
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Tracking the Transition from an ATG9A Vesicle to an Autophagosome. doi.org/10.1080/15548627.202…
Tracking the transition from an ATG9A vesicle to an autophagosome

Tracking the transition from an ATG9A vesicle to an autophagosome

Live-cell imaging is a well-established tool to gain insights into the dynamics of autophagosome formation. We have recently generated a panel of human cancer cell lines that express HaloTagged aut...

tandfonline.com
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A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease. doi.org/10.15252/embj.202211…

A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy...

The EMBO Journal - Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory mechanisms and pathological implications remain poorly understood. Here, via a...

link.springer.com
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ULK phosphorylation of STX17 controls autophagosome maturation via FLNA. doi.org/10.1083/jcb.20221102…
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LGG-1/GABARAP lipidation is not required for autophagy and development in Caenorhabditis elegans. doi.org/10.7554/eLife.85748
LGG-1/GABARAP lipidation is not required for autophagy and development in Caenorhabditis elegans

LGG-1/GABARAP lipidation is not required for autophagy and development in Caenorhabditis elegans

A genetic approach in Caenorhabditis elegans shows that the cleaved and cytosolic form of the ubiquitin-like protein LGG-1/GABARAP is sufficient for both autophagy and embryonic development.

elifesciences.org
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Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation. doi.org/10.1038/s41467-023-3…

Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic...

Nature Communications - CLN3 mutations cause Batten disease, a devastating neurodegenerative lysosomal storage disease. Here, the authors discovered that CLN3 plays a crucial role in both...

nature.com
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A conserved STRIPAK complex is required for autophagy in muscle tissue. doi.org/10.1091/mbc.E23-01-0…

A conserved STRIPAK complex is required for autophagy in muscle tissue | Molecular Biology of the...

A NUAK-Stv complex functions with STRIPAK components to coordinate autophagy in Drosophila muscle tissue.

molbiolcell.org
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Microglial cytokines poison neuronal autophagy via CCR5, a druggable target. doi.org/10.1080/15548627.202…

Microglial cytokines poison neuronal autophagy via CCR5, a druggable target

In the prodromal phase of neurodegenerative diseases, microglia switch to an activated state resulting in increased secretion of pro-inflammatory factors. We reported that C – C chemokine ligand 3 ...

tandfonline.com
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The yeast transcription factor Stb5 acts as a negative regulator of autophagy by modulating cellular metabolism. doi.org/10.1080/15548627.202…

The yeast transcription factor Stb5 acts as a negative regulator of autophagy by modulating...

Macroautophagy/autophagy is a highly conserved pathway of cellular degradation and recycling that maintains cell health during homeostatic conditions and facilitates survival during stress. Aberran...

tandfonline.com
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The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy. doi.org/10.1038/s41467-023-3…
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Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3. doi.org/10.1126/sciadv.adh12…
Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3

Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3

The unique biophysical property of amphipathic α-helix essential for autophagy has been uncovered.

science.org
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PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems. doi.org/10.15252/embr.202256…

PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems

EMBO Reports - The protein kinase PINK1 and ubiquitin ligase Parkin promote removal of damaged mitochondria via a feed‐forward mechanism involving ubiquitin (Ub) phosphorylation (pUb), Parkin...

link.springer.com
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Measurement of SQSTM1 by flow cytometry. doi.org/10.1080/15548627.202…

Measurement of SQSTM1 by flow cytometry

Macroautophagy/autophagy is a regulated cellular degradation process essential as a pro-survival mechanism and integral to the regulation of diverse cellular processes in eukaryotes. During cellula...

tandfonline.com
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PtdIns4p exchange at endoplasmic reticulum-autolysosome contacts is essential for autophagy and neuronal homeostasis. doi.org/10.1080/15548627.202…

PtdIns4P exchange at endoplasmic reticulum-autolysosome contacts is essential for autophagy and...

Inter-organelle contacts enable crosstalk among organelles, facilitating the exchange of materials and coordination of cellular events. In this study, we demonstrated that, upon starvation, autolys...

tandfonline.com
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Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s. doi.org/10.7554/eLife.89185
Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of...

Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of...

cis-membrane insertion of human ATG8 N-terminus facilitates autophagosome membrane expansion independent of autophagic cargo.

elifesciences.org
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Assays of Monitoring and Measuring Autophagic Flux for iPSC-Derived Human Neurons and Other Brain Cell Types. doi.org/10.1007/978-1-0716-3…
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