Innovating the Future of Drug Discovery! Enzymes | Assay kits | Cell lines | Lentivirus | Supporting your advancements in Immunotherapy | Epigenetics | COVID-19
San Diego, CA, USA
Joined May 2009
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BPSBioscience 🔬🦠🧬 retweeted
Huge thanks to @ucsdbiosciences and our generous sponsors @ibidiCells @BPSBioscience @NEBiolabs @NikonInst @nmdp_org @zeiss_micro & Cytoskeleton Inc. We couldn't be more grateful for your help in making this possible!
BPSBioscience 🔬🦠🧬 retweeted
Download this new ebook from @BPSBioscience to learn about developing cancer therapeutics against the PARP family. #AD
bit.ly/49QITbs
BPSBioscience 🔬🦠🧬 retweeted
On today's Tech Snapshot, @BPSBioscience takes us through a deep dive into the power of luciferase-based reporter assays. Read more about the applications of these assays within the drug discovery process: app.scientist.com/blog/2023/…… #celllines #luciferase
BPSBioscience 🔬🦠🧬 retweeted
#OncoAlert Article @CCR_AACR reports #KRAS G12C in NSCLC associated with relapse after surgery. Interesting potential implication to fuel adjuvant studies with G12C inhibitors (sotorasib was just granted FDA priority review yesterday). #LCSM
clincancerres.aacrjournals.o…
BPSBioscience 🔬🦠🧬 retweeted
“How ‘killer’ T cells could boost COVID immunity in face of new variants”. Antibodies are key for an effective vaccine - no question about that. But T cells are less affected by mutations and critical to make good antibodies. Both are needed. nature.com/articles/d41586-0…
BPSBioscience 🔬🦠🧬 retweeted
Our latest paper outlining some of the challenges of targeting SARS-Cov-2 Mpro and PLpro protease is out. Thanks to the great work of @KSteuten @BrettMBabin and @jwiden3 in my lab and our amazing collaborators. pubs.acs.org/doi/10.1021/acs…
BPSBioscience 🔬🦠🧬 retweeted
#Firstlove! You never forget it! And now #CD14 has been recognized as a key marker of dysfunctional #neutrophils in #tumors! Very cool study in #humans and #mice @JExpMed by @GabrilovichLab @FilippoVeglia81 @AyumiMofongo &co.! #MDSC #cancer rupress.org/jem/article/218/…
BPSBioscience 🔬🦠🧬 retweeted
Can deep learning reveal why certain mutations cause cancer?
Why do oncogenes sometimes look like tumor suppressor genes?
Our recent @MolecularCell paper provides answers and finds that altered protein degradation is a large contributor to tumorigenesis🧵cell.com/molecular-cell/full…
BPSBioscience 🔬🦠🧬 retweeted
Rho GTPases are traditionally considered as molecular switches for signaling processes. Here, we discovered that some of them can serve as a "molecular glue" attaching exocytotic vesicles to the plasma membrane,which is critical for lymphocyte cytotoxicity pubmed.ncbi.nlm.nih.gov/3351…
BPSBioscience 🔬🦠🧬 retweeted
A nice article on the discovery of drugs targetting KRAS G12C mutation. nytimes.com/2021/02/05/healt…
BPSBioscience 🔬🦠🧬 retweeted
Hooray, the shiny colorful final version of our paper is out in Science! 😁🧵
science.sciencemag.org/conte…
BPSBioscience 🔬🦠🧬 retweeted
Further utility of E2~Ub activity-based probes for E3 structural studies demonstrated by the Schulman lab.
nature.com/articles/s41586-0…
BPSBioscience 🔬🦠🧬 retweeted
And now for the bad news. *sigh*
It looks like #B117, the more transmissible variant first detected in England, has now picked up the E484K mutation as well. That is the one linked to evading SOME immunity in SAfrica and Brazil.
h/t @_b_meyer
assets.publishing.service.go…
BPSBioscience 🔬🦠🧬 retweeted
Jason McLellan joins #TWiV to reveal all we know about the #SARSCoV2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence bit.ly/3pA2uG7 #COVID
BPSBioscience 🔬🦠🧬 retweeted
Using genome-wide CRISPR screens, @CarolynBertozzi discovered glycoprotein CD43 as a highly specific ligand for Siglec-7 #glycotime #immunotherapy pnas.org/content/118/5/e2015…
BPSBioscience 🔬🦠🧬 retweeted
New SARS-CoV2 'Spike Protein Mutations' track shows amino acid mutations in Spike protein, from community annotation at CoVariants.org. Check out E484, N501, D614G, etc. in genomic context with links to papers & more!
genome.ucsc.edu/s/dschmelt/J…
Thank you @firefoxx66!
BPSBioscience 🔬🦠🧬 retweeted
#SingleCell transcriptional profiling of primary human synovial #sarcoma tumors suggests that combinatorial treatment with HDAC and CDK4/6 inhibitors could enhance tumor immunogenicity.
nature.com/articles/s41591-0… #Cancer #Immunology
BPSBioscience 🔬🦠🧬 retweeted
New #JITC article: Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer ow.ly/AdCs50Dix3A
BPSBioscience 🔬🦠🧬 retweeted
Today, we publish a new article @ScienceMagazine on a promising therapeutic for #SARSCoV2 infection: Plitidepsin (Aplidin). Plitidepsin, an eEF1A inhibitor, potently inhibits virus in vitro and in vivo and is progressing in clinical trials for #Covid_19. science.sciencemag.org/conte…