Researching #SARSCoV2, SARS-CoV, MERS-CoV, Dengue, Zika, and human norovirus at the University of North Carolina. Shared laboratory account.
Chapel Hill, NC
Joined April 2018
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Lots of exciting discussions about antiviral discovery and pandemic preparedness at the READDI symposium last week! @GillingsGlobal @UNC @UNC_Micro_Imm #lovevirology
readdi.org/stories/symposium…
Great showing from past and present UNC coronavirologists at #NIDO2023!
Our collaborative universal vaccine study is out in @NatureComms. These ferritin nanoparticle RBD vaccines protect monkeys against #SARS2 #Beta #Delta and protect mice against #SARSCoV and bat CoVs. Led by @David_RMartinez and @aschaefe29 from our group.
nature.com/articles/s41467-0…
Our Post-Acute Sequelae of SARS-CoV-2 (PASC) mouse pathogenesis model paper is out @ScienceTM . This study was led by @KDinnon @SarahRLeist Ethan Fritch and our #lunginstitute collaborators! Also with support from @aschaefe29 and @LisaGralinski
#COVID19
science.org/doi/epdf/10.1126…
Our #sarbecovirus pathogenesis paper is now out in @mbiojournal . This herculean effort was led by @aschaefe29 @MTFerris with strong support from @SarahRLeist @LisaGralinski @David_RMartinez and our friends from the @Heise_Lab and @msdiamondlab !
journals.asm.org/doi/epub/10…
Our study with @scrippsresearch led by @andrabi_raiees and Dennis Burton is finally out in Nature Immunology. Here we define the protective efficacy of RBD mAbs against SARS-related viruses.
Congrats to @LPVictorTse @David_RMartinez @aschaefe29 and @LisaGralinski !
@NatImmunol
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We're hiring!
We are seeking an experienced virologist to help lead our flavivirus research program. Apply below to join our group at UNC!
unc.peopleadmin.com/postings…
Baric Laboratory retweeted
Fun! #postdocs on #coronavirus #pathogenesis and #antivirals apply here unc.peopleadmin.com/postings…
We are looking for Postdocs to study RNA viral pathogenesis, vaccines and therapeutics @UNCpublichealth #jobs #postdocjobs #coronavirus #SARSCoV2 #COVID19 unc.peopleadmin.com/postings…
Baric Laboratory retweeted
Psyched to share our story about an oral broadly acting #antiviral therapeutic that diminishes #SARSCoV2 disease and works against #MERSCoV too. Heavy lift by @aschaefe29 @David_RMartinez @Baric_Lab @UNCpublichealth @UNCResearch @ScienceTM science.org/doi/10.1126/scit…
We need more oral #antivirals to treat #COVID19. Here we show nucleoside prodrug therapy can improve #SARSCoV2 disease in mice. @David_RMartinez @aschaefe29 @timothysheahan @UNCResearch @UNCpublichealth @ScienceTM science.org/doi/10.1126/scit…
We are excited to share our latest work on SARS-CoV-2 pathophysiology - A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies. biorxiv.org/content/10.1101/…
This manuscript also marks our first use of GeoMx digital spacial profiling, an incredibly useful tool for dissecting the the chronic lung pathophysiology we see after infection.
This work was led by @KDinnon, @SarahRLeist, Kenichi Okuda, Hong Dang and @FritchEthan and it represents an immense amount of work by many, many people in the lab. It would not have been possible without fantastic collaborators in Pathology and at the Marsico Lung Institute.
NC Science, Math, and Engineering Professionals and Trainees: if you are interested in an opportunity that will help engage K12 students in STEM research, please consider volunteering for the NC Science and Engineering Fair Scientific Review Committee: tinyurl.com/2f5fssbb
Our preprint with the @lab_haynes and @Dapeng_LI is out. @David_RMartinez and @aschaefe29 led this from our group and tested the breadth of a #universal #SARSCoV2 vaccine that protected macaques and mice against all tested variants and SARS-like viruses.
biorxiv.org/content/10.1101/…