Unraveling the secrets of bacterial injection needles .. (among other things)
Basel, Switzerland
Joined August 2010
- Tweets149
- Following13
- Followers1.9K
- Likes121
Congrats to @ATejadaArranz & the team for showing that Pseudomonas forms distinct subpopulations during infection, each damaging host tissue by a different mechanism.
Toolbox: single-cell microscopy, 3D image segmentation, high-sensitivity mass spec:
doi.org/10.64898/2026.10.06.…
When Pseudomonas is attacked, it strikes back!
Outer membrane damage triggers a tit-for-tat T6SS retaliation via TagQ/TagR protein complex assembly, activating the PpkA kinase.
Congrats to Maxim & team for uncovering this fascinating mechanism!
nature.com/articles/s41467-0…
In our new paper, we uncover how Burkholderia switches from antibacterial T6SS-1 to eukaryotic-targeting T6SS-5. Surprisingly, actively turning off T6SS-1 assembly prevents mitochondrial damage and apoptosis.
Congrats @christy_chc and the team!
link.springer.com/article/10…
Interested in the Function and Regulation of #T6SS? Do you have relevant experience from your Master's project? Apply to this PhD position in our lab:
biozentrum.unibas.ch/open-po…
A Garmin watch face with a living microbial battlefield powered by your daily stats that is never the same! 🦠⌚️
The BacFighT6 Watch Face runs a live, #T6SS mediated bacterial simulation on your wrist.
apps.garmin.com/apps/eaf881d…
A standalone Garmin watch App to explore simple simulations on your wrist:
apps.garmin.com/apps/3725ea2…
Thanks #Gemini for making this possible!
Source codes are here:
github.com/BaslerLab/BacFigh…
github.com/BaslerLab/BacFigh…
Turn your phone into a bacterial battle ground! 🦠📱
The new BacFighT6 Android app is both a simulation playground AND a Live Wallpaper. Customize cell parameters, tweak visuals, and watch #T6SS battles evolve right on your home screen!
Download here: github.com/BaslerLab/BacFigh…
New version of BacFighT6!
sites.google.com/view/bacfig…
Diffusible toxins produced by prey to impact interactions of Attackers, Defenders and Prey!
This can make #T6SS battles interestingly unstable. Like this simulation with no winner after 100k steps:
baslerlab.github.io/BacFighT…
👇
After another slight increase in the toxin production rate, you get a long battle between Attackers and Prey.
baslerlab.github.io/BacFighT…
If Prey produces enough diffusible toxin, they kill everyone. They pay a high price for synthesis and lysis-dependent release of their toxin.
baslerlab.github.io/BacFighT…
Congratulations to Alea on winning a Gold Medal🥇and a trip to the Taiwan International Science Fair!
The 4th top prize in a row under our mentorship. Huge thanks to @biozentrum, @NCCR_AntiResist, @UniBasel_en for their continuous support.
Read more:
inspiration.sjf.ch/identific…
Check this video describing Alea's high-school graduation project done in our lab:
youtu.be/b9hG_RedCQs?si=1KYN…
Thanks to @biozentrum and @NCCR_AntiResist for support.
Thank you, Katrin (@biozentrum) for a great summary of our paper!
You can also check out this "Behind the Paper" written by @ATejadaArranz:
communities.springernature.c…
New research by @Basler_Lab reveals a surprising microbial trade-off: The bacterium Pseudomonas aeruginosa activates a general defense program to survive “speargun” attacks from rival bacteria, but this defense makes it more vulnerable to antibiotics. 👇biozentrum.unibas.ch/news/de…
