@BenjaminLake15

Researcher🧪| Approaching biological inquiries with chemical intuition #Chemicalbiology | Shawarma Fanatic | Nerd | Dog Stepdaddy

Joined December 2021
  • Tweets4
  • Following104
  • Followers18
Covalent molecular glue degrader of BRD4 from Gray, Ebert, Fischer labs: Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders | bioRxiv biorxiv.org/content/10.1101/…

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue...

Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics[1][1]-[3][2]. Molecular glues...

biorxiv.org
1
7
56
5,528
A new paper from @DrorLab, @MIPS_Australia uses atomic-level simulations to reveal a molecular mechanism by which a ligand can achieve selectivity between nearly identical receptors, enabling the rational design of targeted drugs. Open access: nature.com/articles/s41589-0…

Structural basis of efficacy-driven ligand selectivity at GPCRs

Nature Chemical Biology - The use of atomic-level simulations reveals a molecular mechanism by which a ligand can achieve selectivity between nearly identical receptors, enabling the rational...

nature.com
17
1
66
9,778
Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome dlvr.it/ShDqkz
1
16
86
10,462
Interesting work around creating “PHORCs”, phosphatase recruitment chimeras. There’s soooo much potential in the concept of dephosphorylating proteins, I believe we can do more with such technology over time pubs.acs.org/doi/10.1021/jac…

Protein Phosphatase 5‑Recruiting Chimeras for Accelerating Apoptosis-Signal-Regulated Kinase 1...

Abstract. A normal phosphorylation state is essential for the function of proteins. Biased regulation frequently results in morbidity, especially for the h

pubs.acs.org
10
40
5,331
Load more