#OPENACCESS: A new framework, which also accounts for condensate motion, to correctly determine if a molecule is inside the condensate or in the surroundings. Test your system now! buff.ly/G42Mn6x

Study combines agent-based simulations with coarse-grained thermodynamic analysis to reveal how molecular motor activity drives active asters to reorganize into bundle-like structures, illustrating how mesoscopic architecture shapes mechanical response. buff.ly/HPzHQJH

Special issue call for papers: Stephen H. White: In Memoriam. buff.ly/n1Asc5j

Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: buff.ly/q6m86fo

#OPENACCESS: Hypoxia-responsive HIF-1α-dependent RhoA signaling promotes motility and aerotaxis in polyaneuploid PC3 cancer cells with increased nuclear rounding. Noreen Hosny, Shengkai Li et al. buff.ly/SXVS3jN

Beta cells don’t solo—they play as an orchestra. Barać et al. explore how cellular oscillations synchronize across scales to coordinate hormone secretion. From tiny cellular rhythms to a whole-body signal: biology knows how to keep the beat. buff.ly/ZvmNEp8

#OPENACCESS: Whole-cell spatiotemporal model and multimodal data illuminate the multiscale light responses in a photosynthetic bacterium. Connah G.M. Johnson, Aaron Chan et al. buff.ly/kDBPKlF

Special issue call for papers: Biophysics of Membrane Reactions in the Brain. buff.ly/oxSWx8e

Flexible proteins are molecular yoga masters—twisting through ensembles of conformations rather than holding one pose. Rodriguez et al. ask the big question: how well can our models predict this molecular flexibility? buff.ly/vJV3VRC

How much force does it take to pull an integrin apart? New study reveals a high mechanical threshold required to separate α5β1 integrin transmembrane domains, uncovering a “ratchet-like” role underlying inside-out signaling. buff.ly/wOELmlg

#OPENACCESS: Snapshots of internal protein crystal architecture at the nanoscale. Shervin S. Nia, Ambarneil Saha, Jung Cho, Z. Hong Zhou, Peter Ercius, and Matthew Mecklenburg. buff.ly/radC1JS

#OPENACCESS: An alteration in the binding-unbinding interaction mechanism in a protein-specific condensate system impacts the exchange dynamics, aging, and size distribution of condensates—revealed by simulations. buff.ly/mD1Owam

#OPENACCESS: An energy-based mathematical model of actin-driven protrusions in eukaryotic chemotaxis. Samuel W.S. Johnson, Maddy Parsons, Ruth E. Baker, and Philip K. Maini. buff.ly/7orPKNr

Special issue call for papers: Fazly Ataullakhanov: In Memoriam. buff.ly/wIX4Leg

Tumor cells have a memory—and hypoxia leaves receipts. Sadhu et al. show that how long cells experience low oxygen can shape their future invasive behavior. The past may literally steer the next move. buff.ly/uCgDBVg

In the New and Notable "Lamin A-regulated chromatin organization regulates transcription factor binding," Yuxuan Huang and Alişya A. Anlaş highlight the paper "Lamin A depletion and RSG influence PPARγ DNA binding and chromatin organization in murine..." buff.ly/QzdKqCD

Special issue call for papers: Single-Molecule Approaches to Reveal Structural and Mechanistic Properties of the Genome. buff.ly/4woMhgl

Stark et al. develop a continuum model to describe the dynamics of furrow invagination during development, revealing how dynamic membrane reservoirs and viscoelastic properties of the membrane-cortex shape the kinetics of the observed cell-shape changes. buff.ly/vhdXaFs

#OPENACCESS: Displacement gradients in the lateral region of the organ of Corti dissipate power in the cochlea. Lauren A. Chiriboga, C. Elliott Strimbu, and Elizabeth S. Olson. buff.ly/ZS0GlPt

What if your coverslip could do more than just sit there? Klimovsky et al. turn it into a tiny optical detective, sensing interfacial changes via label-free microrefractometry. Sometimes the smartest part of the microscope is the glass! buff.ly/kRehqzN