@BlacklowLab

News from Steve Blacklow's Lab at @HarvardMed. Managed by lab staff, postdocs and grad students.

 Boston, MA
blacklow.hms.harvard.edu/
Joined September 2021
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  • Following114
  • Followers227
30Media
I'm excited to share my manuscript describing our new insights into how Notch signaling induces transcription of target genes. Thanks to @BlacklowLab and @AdelmanLab and all co-authors! biorxiv.org/content/10.1101/…

Notch induces transcription by stimulating release of paused RNA Pol II without increasing chroma...

Notch proteins undergo ligand-induced proteolysis to release a nuclear effector that influences a wide range of cellular processes by regulating transcription. Despite years of study, however, how...

biorxiv.org
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Temporal tracking Notch from synapse formation To the nucleus #ChromatinHaiku @LenaTveri @GuScanavachi @KirchhausenLab @BlacklowLab doi.org/10.1016/j.devcel.202…
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Building a time-resolved subcellular map, @BlacklowLab tracks the path of the intracellular domain of #Notch during its journey to the cell nucleus and find that the domain isn’t released from the plasma membrane as was previously thought. #CellBiology scim.ag/3Ap
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Congratulations to @HMS_BCMP faculty member Karen Adelmen for her election to the American Academy of Arts and Sciences!  @AdelmanLab @harvardmed
American Academy of Arts & Sciences@americanacad19 Apr 2023
Congratulations to our new members! Just announced! We are honoring the excellence of extraordinary leaders in an array of disciplines and professions. The first members were elected in 1781. Learn who was elected in 2023: amacad.org/news/2023-member-…
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We mourn the passing of Chris T. Walsh, former Chair and Hamilton Kuhn professor emeritus of BCMP: hms.harvard.edu/news/christo…
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“I always assumed that interest in #science manifested itself in becoming a doctor," said Stephen Blacklow of @HMS_BCMP. Instead, he became a #biochemist, devoting his life to treating disease on a #molecular level. proteininnovation.org/2022/1…

With a modern take on a family legacy, Stephen Blacklow joins IPI to push bioscience forward

Stephen Blacklow has biomedical curiosity in his genes. As the newest Board of Directors member at the Institute for Protein Innovation (IPI) and the

proteininnovation.org
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Welcome Stephen Blacklow of @HarvardMed’s @BlacklowLab, IPI’s newest #BoardMember! Blacklow is an expert on HIV infection, cholesterol regulation & tumor development. Now, he’s joined IPI to guide its production of quality #antibody reagents. proteininnovation.org/2022/1…

With a modern take on a family legacy, Stephen Blacklow joins IPI to push bioscience forward

Stephen Blacklow has biomedical curiosity in his genes. As the newest Board of Directors member at the Institute for Protein Innovation (IPI) and the

proteininnovation.org
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Is the activation process of SynNotch the same as that of endogenous Notch? Apparently not. Happy to share our recently published on this in @ACSSynBio. Amazing work by my PhD student Bassma Khamaisi in collaboration with @BlacklowLab @vcluca1. See🧵 pubs.acs.org/doi/10.1021/acs…

Functional Comparison between Endogenous and Synthetic Notch Systems

Abstract. The Notch pathway converts receptor–ligand interactions at the cell surface into a transcriptional response in the receiver cell. In recent years

pubs.acs.org
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BlacklowLab retweeted
Craig S. Smith@craigss17 Feb 2022
Listen to @Pushmeet Kohli, head of Science @DeepMind talk about AlphaFold and other #AI wonders. eye-on.ai/podcast-092 #ML @clearmlapp

DeepMind for Science, sponsored by Clear.ML — Eye On AI

Pushmeet Kohli, the head of DeepMind’s AI for Science and one of the brains behind AlphaFold, the machine learning system that is helping solve the protein folding problem. The episode is sponsored...

eye-on.ai
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BlacklowLab retweeted
Nature Methods@naturemethods11 Jan 2022
It’s finally here!! Our Method of the Year 2021 is….Protein Structure Prediction!! nature.com/nmeth/volumes/19/…
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Exciting new work from the Kruse lab on approaches to assess and predict antibody fragment polyreactivity!
Edward Harvey, PhD@epharvey313 Jan 2022
Excited to share our latest preprint on computational models that assess antibody fragment polyreactivity from sequence alone. We show that these models can be used to prospectively design mutations to decrease polyreactivity, while preserving activity biorxiv.org/content/10.1101/…

An in silico method to assess antibody fragment polyreactivity

Antibodies are essential biological research tools and important therapeutic agents, but some exhibit non-specific binding to off-target proteins and other biomolecules. Such polyreactive antibodies...

biorxiv.org
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Congratulations to Sarah Erlandson of the Kruse lab on defending her dissertation “Structure, Function, and Engineering of Relaxin Hormones and Receptors”! @BBS_Harvard
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There are 325 entries in this week's PDB release. This includes this structure of football-shaped GroEL-ES2 complex (7vwx), just in time for the @NFL post-season! Published in @iScience_CP. View all new entries at pdbe.org/latest
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Congratulations to Joe Loparo on his promotion to Professor of BCMP! @JoeLoparo bit.ly/3JzAi0h
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Thanks to everyone for their contributions to the department pets calendar! If you were not able to pick one up today, they will be available in the mailroom.
Ben Martin@bmart8715 Dec 2021
Brilliant holliday gift from @HMS_BCMP: a department pet calendar featuring 76 pets! The brainchild of @juliamr418!
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Thanks to all who came out to BCMP’s unveiling of Erin Palazzolo Loparo’s mixed media art pieces today! Check out Erin’s beautiful work in the Richardson and Folin-Wu rooms. You can also find her on Instagram at loparoerin.
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Disordered motifs For protein interactions  In elongation  #ChromatinHaiku  science.org/doi/10.1126/scie…

A ubiquitous disordered protein interaction module orchestrates transcription elongation

The transcription elongation machinery is linked through a network of conserved unstructured motifs.

science.org
Katerina Cermakova, cermakova.bsky.social@katacermaku29 Nov 2021
Our awesome collaboration with @vaclav_veverka @hodgeshc @AdelmanLab @zegerdebyser @zeunas @PavelSrb Vanda Lux + many others was just published in Science, where we reveal new roles of unstructured protein in transcription. (1/8) science.org/doi/10.1126/scie…

A ubiquitous disordered protein interaction module orchestrates transcription elongation

The transcription elongation machinery is linked through a network of conserved unstructured motifs.

science.org
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I am delighted to share I’m joining Harvard Medical School @HMS_BCMP as an Assistant Professor in May 2022. The del Mármol lab will study the structural mechanisms that allow animals to smell the world, focusing on insects that vector diseases like malaria, dengue and Chagas.
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Thanks to all who participated in our Pumpkin Carving Contest. Congrats to Melissa Tran for Individual Winner and the Brown Lab for Group Winner!
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BlacklowLab retweeted
bioRxiv@biorxivpreprint1 Oct 2021
Structures of core eukaryotic protein complexes biorxiv.org/cgi/content/shor… #bioRxiv
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