Watching the inner life of a cell
San Francisco, CA
Joined July 2019
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Bo Huang Lab retweeted
New in @CellCellPress from Biohub Investigator @BoHuangLab: AI-designed proteins built from scratch (dubbed "Rhobins") work in living cells and match or even surpass fluorescent tags refined over decades of natural protein engineering.
Read the paper: cell.com/cell/fulltext/S0092…
Bo Huang Lab retweeted
What if pooled screens could measure dynamic cell behavior in real time?
RainBar uses fluorescent protein barcodes and cytoplasmic marker mediated segmentation to perform optical pooled screening in live cells.
Preprint: biorxiv.org/content/10.1101/…
ALT Highly accurate clustering of cells by RainBar barcode. Each cluster represents a unique fluorescent protein barcode identity used in optical pooled screening.
ALT Pooled cells expressing RainBar fluorescent barcodes imaged together in a single field during live cell imaging.
Bo Huang Lab retweeted
LR-ExSIM and LR-ExSTORM reveal subcellular protein organization. @XiaoyuShi2, Qi Li and colleagues report the development of label-retention expansion microscopy (LR-ExM): bit.ly/3qR6vXX
@IanSeiple @BoHuangLab @jiapeichen @dhivkmr @ReiterLab @ExMicroscopy
#Technology
Bo Huang Lab retweeted
Endogenous tagging + 3D live-cell imaging + mass-spec interactome = opencell.czbiohub.org, an open-source map of the human proteome. So excited for our first release, wonderful collaboration with @labs_mann @loicaroyer & many other colleagues. @OpenCellCZB
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization biorxiv.org/cgi/content/shor… #bioRxiv
Bo Huang Lab retweeted
It takes a village: great collaboration between @czbiohub @JswLab @BoHuangLab Barbara Panning @LiGanLab - thanks to all.