CEO @artan_bio · Codon Therapy for the mutations of aging · Bay Area ↔ St. Pete · Science, longevity, family
San Francisco Bay Area
Joined May 2025
- Tweets596
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- Followers164
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Brian Bodemann retweeted
Clonal hematopoiesis isn't only about age.
Cancer therapy can select for it, and new data show the same after CD19 cell therapy. 🧬👇
@vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
Topical RNA has a barrier problem. One classic paper shows how hard it is. A new one shows engineered carriers can still get RNA into skin. 🧬👇
@vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
Amazing time in Boston. Blessed to be a part of an amazing community working to do good. #twitter instagr.am/p/DfiFBGomVgw/
Brian Bodemann retweeted
Where do premature stops in human disease come from? Many come from one codon.
Two papers, and a number from our own analysis. 🧬👇
@vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
Different body sites, different mutation burdens.
Fowler et al. mapped skin clones across body sites. Most mutations were UV-related. 🧬
doi.org/10.1158/2159-8290.CD…
@vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
Saturday reading.
Martincorena et al., Science 2015: in sun-exposed eyelid skin, over a quarter of cells carried cancer-causing mutations, and the skin still worked normally. Aged skin is a patchwork of thousands of clones. 🧬 ethereum:0x7b66e84be78772a3afaf5ba8c1993a1b5d05f9c2 @artan_bio @vitarnabio @Bodeeeman @aschwartzphd @vita_dao
doi.org/10.1126/science.aaa6…
Brian Bodemann retweeted
Our community funded the science. Now $VITARNA holders help decide the next experiment.
The bet underneath this vote: you don't have to repair every broken letter in your DNA. You just have to get the cell to read past it.
VRNAP-6 asks whether that changes how a mouse ages -> carried in every cell from birth, aged beside unedited littermates, judged on lifespan and healthspan.
@vitarnabio proposes testing it, starting with tolerability. No new raise.
👉Read the proposal and cast your vote.
snapshot.org/#/s:vitarna.eth…
As we age, cells pile up "stop" errors in their DNA that cut proteins short.
@artan_bio's Codon Therapy is built to read through them.
VRNAP-6 asks: do we test it for a whole lifetime?
🐭 Mice carry the fix from birth
📊 We track lifespan, frailty, grip, balance, gait 👇
Brian Bodemann retweeted
More insight into @artan_bio and our vitabeauty project.
Sunlight's signature mutation is C→T, and at methylated CpG sites it's especially easy to make. In a CGA codon, that creates a stop.
The chemistry, in the papers: 🧬👇
@vitarnabio @vita_dao @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
Attention $VITARNA token holders:
We want your feedback on a proposed experiment! Token holders actually have a say! Vote below. This is #desci in action!
snapshot.org/#/s:vitarna.eth…
@vitarnabio @vita_dao @Molecule_sci @BioProtocol @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
For those interested, we share updates on the Vitarna Telegram thread here:
t.me/vitarna
Brian Bodemann retweeted
Attention $vitarna token holders. Here’s another thread on the data of our therapeutic:
Does the codon suppressor reach tissue? We dosed mice once with AAV9 and measured codon suppressor expression 14 days later. 🧬👇
@vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
Attention $vitarna token holders:
Artan-102 restores full-length p53 in Calu-6 cells with R196X on both alleles.
R196X is a CGA→TGA stop. The Artan-102 band runs stronger than the G418 control. Not quantitative. 🧬
@vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
The big banks are catching on. What we’re doing in the desci space is different! @vitarnabio @vita_dao @artan_bio
Brian Bodemann retweeted
What would happen if we could stop the functional consequences of somatic mutations we know accumulate over time?
Let's walk through what the data say. 🧬👇
@vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
Attention $vitarna token holders and longevity enthusiasts. As we go into @Jefferies London, we’re sharing more the science behind Artan. You’ll see how we’re different.
The problem:
One C→T change at a CGA codon turns arginine into a premature stop. It happens on its own, and it builds up with age.
Here's how it works and why it's the stop we built around. 🧬👇
@vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
1/6 🧬 A single genetic letter can stop a critical protein from being made.
What if we could restore it?
Human genetic research in Parkinson’s disease highlights exactly the class of mutations ARTAN Bio’s VitaRNA technology is designed to address.
Here’s why this matters for $VITARNA. 🧵 @vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
No success so far in using fusion to turn mercury into Bitcoin, thankfully.
Last month, we demonstrated high-rate alchemy: turning mercury into real, stable gold, beating CERN’s record by a factor of 10.
Last week, we enriched isotopes in the world’s most powerful plasma centrifuge, beating the Soviet record that stood for 40 years.
Now, we’re building a fusion reactor in San Francisco to achieve record power density.
Brian Bodemann retweeted
Excited to receive this award! Hope to see some friends attend! Let’s keep building!
