
ALT The CoED Bioreactor purifies cells based on their ability to migrate through a cell permeable membrane in response to a specified set of chemokines. Naive cells migrate from tissues in Niche 1 to Niche 2. In Niche 2 cells are activated so that they change their migratory phenotype. Activated cells are then recruited to Niche 3 by a set of chemokines specific for activated cells. Purified, differentiated, proliferating cells are harvested from Niche 3. This system mimics the natural migration of immune cells in and out of lymph nodes.

ALT Diagram of analysis design for PGC MDD GWAS. Diverse ancestries discovery GWAS analyses starts with European ancestry meta-analysis, which is used for bioinformatic and mechanistic analysis; fine-mapping and expression-based gene mapping; tissue, cell, and pathway enrichment analyses; and drug target enrichment analyses. All ancestries meta-analysis is used for predictive testing within and across ancestries.



























