@BryanCopits

Pain neuroscientist and electrophysiologist. Trying to understand how neurons are wired into circuits. New PI at WashU in St. Louis https://xitter.cf/t.co/TPrJaftjlu

sites.wustl.edu/copitslab/
Joined October 2017
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  • Followers604
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1/3 It's important to note that most mApple-based biosensors exhibit blue light-illuminated photoactivation, and proper controls (e.g. mutant-sensor or biosensor-only controls) should be included in combined use with blue-light optogenetics or dual-color recording.
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This report is indeed short. You have time to read it. Many of us have some power to help change it. So let’s do it.
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Bryan Copits retweeted
Rob Gereau@robgereau28 Nov 2023
a little human spinal cord physiology to brighten your feed. Recording by @JunNanLi5, assist by @BryanCopits and outstanding tissue recovery team (it takes a village) this afternoon. Thanks to @NIHendaddiction for funding this exciting work.
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Alles Lab@AllesLab5 Nov 2023
📜 Preprint alert! Our latest work on #ephys analyses of human DRG & hiPSC-derived sensory neurons is now online @biorxivpreprint Thanks to the incredible team that made this possible! We hope this will be a useful resource to #pain researchers biorxiv.org/content/10.1101/…

Electrophysiological analyses of human dorsal root ganglia and human induced pluripotent stem...

Human induced pluripotent stem cell-derived sensory neurons (hiPSC-SNs) and human dorsal root ganglia (hDRG) neurons are popular tools in the field of pain research; however, few groups make use of...

biorxiv.org
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We're really excited about this project! To piggyback off of @NeuroTejeda's tweet, we're also hiring. Please reach out if you're interested in protein engineering, slice electrophysiology, and/or high throughout screening.
Hugo Tejeda@NeuroTejeda9 Nov 2023
My lab is hiring a postdoc to work on a BRAIN Initiative funded position in collaboration with Bryan Copits and Patrick O'Neill to develop novel optogenetic tools to selectively manipulate user defined afferent inputs onto user defined post-synaptic neurons. DM or email
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Bryan Copits retweeted
Ofer Yizhar@OferYizhar13 Oct 2023
If you’re collaborating with Israeli PIs, think about whether you could invite one of their international trainees for a short stay so that they can get some work done while they are unable to return to their home lab.
Jonathan Kipnis 🟦
@jonykipnis13 Oct 2023
I’ve just learned from another PI that all foreign trainees are evacuated by their embassies. The labs are emptying. This will impact Israeli science, unfortunately. I don’t think we can do much about it, but if you think there is anything we, your American colleagues, can do to help - just let us know.
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Featured in August issue: @JudyYoo and team (@UCincyMedicine) characterize the impact of early life iron deficiency on nociception development. - Perinatal iron deficiency exacerbates post-surgical pain in adulthood Full access for 30 days: jpain.org/article/S1526-5900…

Early-Life Iron Deficiency Persistently Alters Nociception in Developing Mice

Clinical association studies have identified early-life iron deficiency (ID) as a risk factor for the development of chronic pain. While preclinical studies have shown that early-life ID persistently...

jpain.org
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Bryan Copits retweeted
Will Renthal@willrenthal6 Jul 2023
Congrats to co-first authors @shamsChronicles, @MengyiXu4 and all our @NIHendaddiction U19 collaborators @UTDPainLab @robgereau et al. for building such a useful resource - harmonized.painseq.com - for studying sensory ganglia cell types across species! xitter.cf/shamsChronicles/status…
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Bryan Copits retweeted
Shams@shamsChronicles6 Jul 2023
Excited to share my first postdoc study, titled “Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia”. biorxiv.org/content/10.1101/… 1/n

Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia

Peripheral sensory neurons in the dorsal root ganglion (DRG) and trigeminal ganglion (TG) are specialized to detect and transduce diverse environmental stimuli including touch, temperature, and pain...

biorxiv.org
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Ofer Yizhar@OferYizhar2 Jul 2023
New preprint from the lab! We conducted a systematic analysis of bistable optoGPCRs for presynaptic inhibition, which led to the characterization of PdCO: a bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits biorxiv.org/content/10.1101/…

A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits

Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how the activity of such long-range connections contributes...

biorxiv.org
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Day 2 @NAPainSchool: Great presentation @JudyYoo! Her research focuses on how early life injury could impact the development of spinal astrocytes. #NAPainSchool
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biorxiv.org/content/10.1101/…

Intrinsic Homeostatic Plasticity in Mouse and Human Sensory Neurons

In response to changes in activity induced by environmental cues, neurons in the central nervous system undergo homeostatic plasticity to sustain overall network function during abrupt changes in...

biorxiv.org
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🚨Paper Alert🚨 Very happy to share my first postdoctoral work from the Gereau Lab @robgereau . This collaborative work, co-led by former member Lisa McIlvried, show that homeostatic plasticity is engaged in mouse and human DRG neurons. biorxiv.org/content/10.1101/…

Intrinsic Homeostatic Plasticity in Mouse and Human Sensory Neurons

In response to changes in activity induced by environmental cues, neurons in the central nervous system undergo homeostatic plasticity to sustain overall network function during abrupt changes in...

biorxiv.org
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We’re hiring! Projects combine genomics, in vivo ephys and synaptic physiology to understand how plasticity in basal ganglia circuits give rise to maladaptive decision making- with a focus on models of substance use disorder and chronic pain! (1/n)
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Very excited to share the first paper from the lab on bioRxiv!😊Here, we establish that ketamine rescues stress-induced anhedonia via cell-type-specific adaptations as well as information integration in the NAc via discrete excitatory synapses. biorxiv.org/content/10.1101/…

Ketamine rescues anhedonia by cell-type and input specific adaptations in the Nucleus Accumbens

Ketamine’s role in providing a rapid and sustained antidepressant response, particularly for patients unresponsive to conventional treatments, is increasingly recognized. A core symptom of depressi...

biorxiv.org
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Highlighting ✨#BlackExcellence✨ in the #BlackInBiophysicsWeek 2023 organizers 🙌🏾 @JohnDR01 is co-founder of @BlackInBiophys. He is a #DSPAN Scholar (@NINDSDiversity) and co-organizer of #BIBPSWeek 2021. He is currently a postdoc at @WUSTL 💪🏾 #BlackInBiophysics Events🧵👇🏾
Black In Biophysics@BlackInBiophys8 May 2023
We are excited to share our EVENTS for #BlackInBiophysicsWeek 2023!!! 🙌🏾 We will be hosting #BIBPSWeek from Monday, 5/22 to Friday 5/26. Please RT and help us spread the word! A thread of Events below👇🏾 #BIBPS23 #BlackInBiophysics #BlackInBiophys #BlackInX
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Great people doing incredible science in a fun and collaborative group. I cannot recommend Rob's lab enough
Rob Gereau@robgereau5 May 2023
3 postdocs landing dream jobs, 1 PhD student graduating means: A)I'm so proud of these amazing scientists and happy for their success & B) We have opportunities to recruit new colleagues!
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Tao@TaoChelab3 May 2023
Very glad to share our recent work on kappa opioid receptor. Congratulations to everyone involved in this work! Great teamwork! Ligand and G-protein selectivity in the κ-opioid receptor disq.us/t/4g4kkwl
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