@CFredlender

PhD👩🏼‍🔬 | Neuro 🧠 & Drug Discovery 💊

 UC Irvine
Joined August 2021
  • Tweets53
  • Following76
  • Followers52
A new paper from @TheAlbrecht_Lab and @LJSeabrook developed a targeted protein degradation platform, MrTAC, that enables arginine methylation-driven degradation of intracellular proteins in lysosomes doi.org/10.1038/s41589-024-0…
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Oded Rechavi
@OdedRechavi21 Jan 2024
Being a scientist is amazing - one moment you're having a brilliant idea and BOOM! 10 years and 1 million $ later it's published in a journal
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The Nobel Prize
@NobelPrize4 Oct 2023
Did you know that the properties of an element can change when shrunk to the nanoscale?
60%Yes
40%No
5,955 votes • Final results
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We are pleased to announce that our biologics license applications (BLA) for our potential treatment for sickle cell disease (SCD) & beta thalassemia have been accepted by the FDA & our application for SCD has been granted priority review. Learn more: news.vrtx.com/news-releases/…
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Alexander Huth@alex_ander1 May 2023
In the latest paper from my lab, @jerryptang showed that we can decode language that a person is hearing (or even just thinking) from fMRI responses. nature.com/articles/s41593-0…

Semantic reconstruction of continuous language from non-invasive brain recordings

Nature Neuroscience - Tang et al. show that continuous language can be decoded from functional MRI recordings to recover the meaning of perceived and imagined speech stimuli and silent videos and...

nature.com
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Dr Meming@Dr_Meming12 Apr 2023
Me: Yeah I can do that experiment Also me:
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We are pleased to announce that we’ve completed the submission of our Biologics License Applications (BLAs) to the U.S. FDA for our potential treatment for sickle cell disease and beta thalassemia. Learn more: news.vrtx.com/news-releases/…
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Brian Paegel@BrianDNA31 Mar 2023
My third @UCIrvine graduate student, the incomparable Amanda Nguyen, advanced to Ph.D. candidacy today! BOBA beads coming soon! Also, note the tiara. #queen @TheAlbrecht_Lab @UCI_SPPS
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Engineering an inhibitor-resistant human CSF1R variant for #microglia replacement. A new study from Jean Paul Chadarevian @JPChadarevian, Sonia I. Lombroso @Sonia_Lombroso, Mathew Blurton-Jones @BlurtonJonesLab F. Chris Bennett @FChrisBennett & colleagues: bit.ly/3GBa2Da
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Dan Nomura
@DanNomura28 Dec 2022
Paper out of Genentech on Targeted protein degradation via direct 26S proteasome recruitment | Nature Chemical Biology nature.com/articles/s41589-0…

Targeted degradation via direct 26S proteasome recruitment

Nature Chemical Biology - Discovery of macrocyclic ligands to the 19S regulatory particle protein PSMD2 enables the synthesis of heterobifunctional molecules that demonstrate proof-of-concept,...

nature.com
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Jorge Almagro@almagro_jorge22 Dec 2022
Merry christmas from my organoids! 🎄
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Tyler Sloan@quorumetrix21 Dec 2022
I’ve made this video as an intuition pump for the density of #synapses in the #brain. This volume ~ grain of sand, has >3.2 million synapses (orange cubes). Peeling them away leaves only inputs on 2 #neurons. Zooming in, we see the synapses localized to the dendritic spines. #b3d
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The Age of Cell Therapy is here. Emily Whitehead shows you why. 🙏
CBS Sunday Morning 🌞
@CBSSunday30 Oct 2022
Emily Whitehead became the first child to receive genetically-modified T cell to treat her leukemia. Her story helped launch @EWhiteheadFdn and the field of cellular medicine, as told in a new book, #TheSongoftheCell by the Pulitzer Prize-winning, @DrSidMukherjee.
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Maddie Lee, PhD@m_janelee24 Oct 2022
Got my Halloween costume all picked out :)
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Dan Nomura
@DanNomura22 Oct 2022
From ⁦@SchreiberStuart⁩ and ⁦@NovartisScience⁩: DNA-encoded library (DEL)-enabled discovery of proximity-inducing small molecules | bioRxiv biorxiv.org/content/10.1101/…

DNA-encoded library (DEL)-enabled discovery of proximity-inducing small molecules

Molecular glues and bifunctional compounds that induce protein–protein associations provide a powerful and general mechanism to modulate cell circuitry. We sought to develop a platform for the direct...

biorxiv.org
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Sam Westwood@westwoodsam119 Oct 2022
When you have no data to present at the lab meeting @AcademicChatter @AcademicsSay
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Robert Spitale@SpitaleLab19 Oct 2022
Years in the making. Excited to announce the launch of the UCI Center for Neurotherapeutics. Drug discovery ENGINE aimed at uncovering new medicines to treat neurodegenerative diseases. @UCI_SPPS @UCIrvine news.uci.edu/2022/10/18/uci-…

UCI launches Center for Neurotherapeutics to facilitate drug discovery and therapy delivery

UCI has launched a Center for Neurotherapeutics to facilitate drug discovery for neurological diseases. It’s led by Dr. Albert LaSpada, Distinguished Professor of pathology, neurology and biological...

news.uci.edu
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Oded Rechavi
@OdedRechavi16 Aug 2022
Faculty members when someone retires and there's lab space up for grabs
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Base editors hit the clinic go.nature.com/3PGys03 The first clinical trial of a drug designed to change a DNA base at a specific location has just started. Read about the base editor pipeline for cardiovascular and haematological diseases and the challenges for the field here
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