@CKChenLab

Account run by lab members Exploring #circRNA regulation, function, technology, and therapeutics WashU Med Cell Biology & Physiology

 St. Louis, MO
sites.wustl.edu/cbpchenlab/
Joined April 2023
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Excited to share our work with @DjuranovicLab on bioRxiv, introducing RAPPL-Seq! 🧬 doi.org/10.64898/2026.10.20.… #RNA #RiboSeq

RAPPL-Seq Enables Rapid, High-Sensitivity Ribosome Profiling of Scarce Samples

Ribosome profiling is a powerful method for transcriptome-wide monitoring of translation activity in vivo, but its use is limited by lengthy protocols, reliance on specialized equipment and ineffic...

biorxiv.org
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Most excitingly, RAPPL-Seq enables translatome profiling from tiny human biopsies (<1 mg), including glioblastoma and adjacent non-tumor brain tissue. We also identified tumor-enriched translation signatures, opening new ways to study translational regulation in human diseases!
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@DjuranovicLab
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Key advances: ⚡~16× more RNA from 20× fewer cells ⏱️ Isolation in <3 hours 🔬 High-quality profiling from as few as 200K cells
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Most excitingly, RAPPL-Seq enables translatome profiling from tiny human biopsies (<1 mg), including glioblastoma and adjacent non-tumor brain tissue. We also identified tumor-enriched translation signatures, opening new ways to study translational regulation in human diseases!
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We are so back! We have new faces, data, and upcoming publications in the Chen Lab at WashU Med. Accepting DBBS rotation students for the upcoming school year! Stay tuned for cutting edge circRNA and ribosome profiling research🧬
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Heads up! CK will be attending the Post-Transcriptional Gene Regulation Gordon Research Conference from July 20-23 in Portland, Maine. He'll be presenting a poster on the latest research going on in his lab. Make sure to check it out! #academicresearch #rnabiology #circRNA
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Together with Chun Kan Chen's and @slavicaPD groups we have recently optimized our RAPPL method for the isolation of ribosomes and ribosome fragments from biopsies (5-10mg), tissues (1-5mg) and small blood samples (100-500ul). Soon more on RAPPL Ribo-Seq... Images from ribosome isolation from 100ul of blood, RAPPL-RiboSeq reads and comparison of low expression genes with RAPPL RiboSeq on 250K cells with 10 million cells with classical method. Pending patent #63/694,196 (WU Ref No. 020910/US) nature.com/articles/s41467-0…
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Guess who happens to be traveling today from GRC when Windows is down...spent whole day among different airports with flight delayed or canceled...
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Still waiting at the airport...just hope I can get back to St. Louis soon...
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Glad to be at the GRC RNA conference: Post-transcriptional Gene Regulation. Had great discussion with many talented RNA scientists! Perfect weather for a boat tour as well!
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Want to learn more about circular RNAs and immunity? Come join our CB&P Seminar tomorrow (April 1st) at 1:00 PM!
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Glad to receive The Young Investigator Award from The Cancer Research Foundation! Thanks for the insights and help from @StratmanLab @sastewartlab and Milan Chheda. Excited about the applications of circRNAs in cancer treatment!
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cancerresearchfdn.org/progra….

Young Investigator Awards - Cancer Research Foundation

The Cancer Research Foundation Young Investigator Award was established more than 30 years ago to support early career researchers as they establish their own labs and assemble their first data sets....

cancerresearchfdn.org
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Thrilled to be nominated to be featured in the RNA Society Spotlight Series (rnasociety.org/chun-kan-chen…)! Thanks to Julieta Rivosecchi @jurivosecchi and The RNA Society @RNASociety for this incredible opportunity to share my work and my journey in RNA research!

Chun-Kan Chen, PhD - RNA Society

The human genome encodes a subset of non-coding RNAs that are covalently closed forming circular RNAs (circRNAs). As an Assistant Professor, Dr. Chun-Kan Chen is deeply fascinated by the unique...

rnasociety.org
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Want to learn more about the exciting discoveries in circRNA? Come to our CBP Seminar Series next Tuesday (Feb 6th)!
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Absolutely thrilled to receive the Siteman Research Program Catalyst Award! A first step and a milestone in our journey into cancer research! Thanks to the selection committee for recognizing our work. Excited about expanding our circRNA research towards cancer therapeutics!
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