@CPP_opt
Www.cppopt.org
Joined February 2018
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  • Following28
  • Followers168
10Media
We did it! First CPPopt feasibility and safety trial! Results are here doi: 10.1089/neu.2021.0197 Is precision medicine in #TBI in #CriticalCare feasible? CPPopt as an individualised dynamic CPP target for protecting the brain. Thanks #COGiTATE team for this work!
Marcel aries@aries_marcel23 Aug 2021
The Autoregulation-Guided Cerebral Perfusion Pressure after Traumatic Brain Injury (COGITATE) results have been published!! @AriErcole @DrSmielewski @Menon_Cambridge @TasJeanette @iccvanderhorst @joseph_aotearoa @pja_hutch @erta_beqiri @GMeyfroidt Link: lnkd.in/dfjp-WDH
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The President’s Commendation for a sustained contribution to the College was presented to Dr Rana Hafiz Ur Rehman. Dr Ari Ercole gave the Macintosh Professor Lecture. Seen here with President Dr Claire Shannon and Prof Iain Moppett. Read more: ow.ly/NsKo50UeHFx
HRH The Princess Royal presenting the President’s Commendation to Dr Rana Hafiz Ur Rehman.

ALT HRH The Princess Royal presenting the President’s Commendation to Dr Rana Hafiz Ur Rehman.

Dr Ari Ercole holding a certificate for the Macintosh Lecture with President Dr Claire Shannon and Professor Iain Moppett.

ALT Dr Ari Ercole holding a certificate for the Macintosh Lecture with President Dr Claire Shannon and Professor Iain Moppett.

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Wonderful news for a remarkable colleague, friend, and doctor.
Royal College of Anaesthetists@RCoANews8 Jan 2024
Following recommendations from @NIAAResearch, we are pleased to announce that 2 Macintosh Professorships have been awarded. @RonelleMouton - RCoA & VASGBI Macintosh Professor @AriErcole - RCoA Macintosh Professor Congratulations both. ow.ly/4W9m50QoPzW
Pictures of Dr Ronelle Mouton, Honorary Associate Professor of Anaesthesia, Translational Health Sciences, Bristol Medical School and Dr Ari Ercole an anaesthetist and intensive care physician, holding a substantive consultant post in neuroscience and intensive care medicine at Cambridge University Hospitals NHS Foundation Trust.

ALT Pictures of Dr Ronelle Mouton, Honorary Associate Professor of Anaesthesia, Translational Health Sciences, Bristol Medical School and Dr Ari Ercole an anaesthetist and intensive care physician, holding a substantive consultant post in neuroscience and intensive care medicine at Cambridge University Hospitals NHS Foundation Trust.

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Traumatic brain injury #TBI phenotypes from @CenterTBI #ICU data by probabilistic time-series clustering 𝗧𝗲𝗺𝗽𝗼𝗿𝗮𝗹 𝘃𝗮𝗿𝗶𝗮𝘁𝗶𝗼𝗻 of brain injury 𝗯𝗶𝗼𝗺𝗮𝗿𝗸𝗲𝗿𝘀 = missing link in describing the 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 course authors.elsevier.com/c/1i5LY… @TheLancetNeuro
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ICP is strongly confounded by therapeutic intensity level (TIL) after #TBI. Measuring TIL crucial to understand severity Various TIL scores validated in @CenterTBI doi.org/10.1089/neu.2023.037… @TBI_data_guy nails TIL representing 'refractory' ICP: TILᵐᵉᵈ≥7.5
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A solution to the age-old problem of where to zero the transducer in neurocritical care... rdcu.be/dlTOs doi.org/10.1007/s12028-023-0…
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Does what happens in #ICU stay in ICU after #TBI? Well done @TBI_data_guy for time-series #machinelearning model ingesting 𝑎𝑙𝑙 @CenterTBI data with minimal pre-processing looking at contribution of clinical course events to outcome in @npjDigitalMed nature.com/articles/s41746-0…
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Precision medicine to improve outcome after traumatic brain injury: data-driven approaches to identify pathophysiological or pathobiological mechanisms to individualize treatments 🧠suggestions for #TBI phenotypes 🧠methodological considerations #FOAMcc 🔓 rdcu.be/dhtsr
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Machine learning and novel algorithmic techniques show great potential, but need to be applied and interpreted correctly Right question+right data+right method doi.org/10.1038/s41591-022-0… @CC4AIM
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Unsupervised clustering in @CenterTBI finds 6 stable endotypes of #TBI in the #ICU ⚠️Systemic metabolic stress important differentiating patients as well as traditional GCS classification doi.org/10.1186/s13054-022-0… rdcu.be/cSxc0
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#TraumaticBrainInjury research often dichotomises outcomes. Here's how to handle ordinal outcomes from @shubhayu_neuro including a #machinelearning approach using 𝙖𝙡𝙡 the @CenterTBI features for best prediction doi.org/10.1371/journal.pone…
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Some 𝘷𝘦𝘳𝘺 important things to know about the challenges of large-scale observational data collection in #TBI from @CenterTBI doi.org/10.1007/s12028-022-0…
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Primary analysis of @global_neuro Global Neurotrauma Outcomes Study #GNOS published tonight @TheLancetNeuro. thelancet.com/journals/laneu… Phenomenal collaboration of clinicians from 57 countries 🌍. #WFNS2022 #globalneurosurgery #globalneurotrauma #TBI
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Yes, and Cogitate study is one of the most read papers in 2021!!
David L. Brody@DavidLBrody17 Jan 2022
Check out the most read papers from Journal of Neurotrauma. liebertpub.com/action/showMo…
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COGiTATE results presented at the #BNRG2021 by our team member @erta_beqiri Great meeting, fantastic talks! Inspiration for the future @BrainPhysics @icm_plus
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Reduced physiological cross-talk associated with mortality after #TBI Well done Giovanna, @BrainPhysics @DrSmielewski @erta_beqiri @pl219_Cambridge @AriErcole and all @CenterTBI collaborators doi.org/10.1007/s12028-021-0…
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First ever prospective randomised controlled trial to assess feasibility and safety of a 'digital biomarker' for individualised care of #TBI patients on #ICU ➡️ both feasible and safe #COGITATE doi.org/10.1089/neu.2021.019…
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@BrainPhysics
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cppopt.org
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Glasgow Coma Score & pupil reactivity=crucial #TBI outcome determinants but timepoints frequently missing in real-world data Evaluation of methods for effective imputation by @CenterTBI... ... the answer depends on the question! doi.org/10.1371/journal.pone…
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