Pierre Caron (@CaronPierre13) header
Pierre Caron (@CaronPierre13) profile picture

Pierre Caron

@CaronPierre13

@IBS_Grenoble @IRIG_Grenoble @cea_grenoble | CNRS researcher | @Prelights | @EDRA_Webinars

 Grenoble, France
ibs.fr/en/research/assembly-dynamics-and-reactivity/
Joined December 2018
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Photo by Pierre Caron (@CaronPierre13)Photo by Pierre Caron (@CaronPierre13)Photo by Pierre Caron (@CaronPierre13)Photo by Pierre Caron (@CaronPierre13)Photo by Pierre Caron (@CaronPierre13)Photo by Pierre Caron (@CaronPierre13)Photo by Pierre Caron (@CaronPierre13)Photo by Pierre Caron (@CaronPierre13)Photo by Pierre Caron (@CaronPierre13)Photo by Pierre Caron (@CaronPierre13)
New Online! The molecular basis of transcription initiation by RNA polymerase II dlvr.it/TVKRXr
Image from Nature Reviews Molecular Cell Biology (@NatRevMCB)
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Pierre Caron retweeted
hnisimasu (@hnisimasu) profile picture
hnisimasu@hnisimasuAug 8
Reverse transcriptases challenge the central dogma of biology, again: Cell cell.com/cell/fulltext/S0092…
Reverse transcriptases challenge the central dogma of biology, again

Reverse transcriptases challenge the central dogma of biology, again

In this issue of Cell, Wang et al. reveal the mechanism of a bacterial antiphage system that contains two reverse transcriptases. Through an unprecedented process, the enzymes synthesize double-str...

cell.com
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Happy to share this prelights on how PARylation regulate transcription during BER. Congratulations to the authors for this beautiful work.
preLights (@preLights) profile picturepreLights@preLightsApr 2
Attachment of ADP-ribose molecules to RNA Polymerase II allows its traffic regulation on transcribed genes in response to oxidative DNA damage 🧬 Insightful #preLight by Élise & @CaronPierre13 on preprinted work from @GregersenLab ⬇️👀 prelights.biologists.com/hig…
Oxidative stress triggers RNAPII arrest through PARylation and DNA damage - preLights

Oxidative stress triggers RNAPII arrest through PARylation and DNA damage - preLights

Attachment of ADP-ribose molecules to RNA Polymerase II allows its traffic regulation on transcribed genes in response to oxidative DNA damage

prelights.biologists.com
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🪐 Il a fallu 9 ans et 4,8 milliards de kilomètres pour obtenir ces images. Ce sont les montagnes glacées de Pluton 🤯
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The full program for the 18th EDRA webinar (Dec 16th, 4:00 pm CET) is now available! We are excited to share the details of this final session of the year, featuring talks on RNA damage in chemotherapy, BER–MMR crosstalk, and mitochondrial DNA repair. lnkd.in/en7HV9wK
Image from EDRA (European DNA Repair Alliance) (@EDRA_Webinars)
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New online! Kinetic control of mammalian transcription elongation bit.ly/4ipj2wp
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Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope dlvr.it/TPN3ff
Image from Molecular Cell (@MolecularCell)
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Our newly developed ChIP-CryoEM technique has, for the first time, visualized the moment when the UV-DDB protein recognizes and repairs UV-induced DNA damage within cells. nature.com/articles/s41467-0… #cryo #structure #biology
Structural basis of cyclobutane pyrimidine dimer recognition by UV-DDB in the nucleosome

Structural basis of cyclobutane pyrimidine dimer recognition by UV-DDB in the nucleosome

Nature Communications - UV-DDB is a protein that plays a key role in recognizing DNA lesions. Here, the authors determine the cryo-EM structure of UV-DDB bound to UV-damaged chromatin in human...

nature.com
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Pierre Caron retweeted
nature (@Nature) profile picture
nature
@Nature30 Oct 2025
Nature research paper: Evidence for improved DNA repair in long-lived bowhead whale go.nature.com/3Lzg1NH
Evidence for improved DNA repair in the long-lived bowhead whale

Evidence for improved DNA repair in the long-lived bowhead whale

Nature - Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.

nature.com
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Online Now: Cryo-EM reveals open and closed Asgard chromatin assemblies dlvr.it/TNwxln
Image from Molecular Cell (@MolecularCell)
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Pierre Caron retweeted
Nitika Taneja (@Tanejalab) profile picture
Nitika Taneja@Tanejalab21 Aug 2025
Our lab’s insights on a recently published Science study that highlights ASB7 as a cell-cycle-regulated ubiquitin adaptor that restrains heterochromatin spread by targeting SUV39H1 for degradation. Check out our views & more of this exciting work 👉: nature.com/articles/s41392-0…
Fencing the genome: ubiquitin signaling restricts heterochromatin spread

Fencing the genome: ubiquitin signaling restricts heterochromatin spread

Signal Transduction and Targeted Therapy - Fencing the genome: ubiquitin signaling restricts heterochromatin spread

nature.com
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nature.com/articles/s41586-0…
Structural basis for the dynamic regulation of mTORC1 by amino acids

Structural basis for the dynamic regulation of mTORC1 by amino acids

Nature - Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers...

nature.com
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🎉🎉 Elated to share that my Ph.D work is now published, showing Xist upstream elements are important for Xist and autosomal gene expression. Very thankful to my Ph.D supervisor @srimontagayen, to @DimpleNotani, to @Hemantcnaik666 & the entire team for their contributions!
SrimontaGayen_Epigenetics lab (@srimontagayen) profile pictureSrimontaGayen_Epigenetics lab@srimontagayen8 Aug 2025
Published now @genomeresearch how Xist upstream elements regulate gene expression. Excellent work by @SudeshnaMajum18 Thanks @iiscbangalore @ANRFIndia @DBTIndia @EMBO_YIP for support. genome.cshlp.org/content/ear…
Image from SrimontaGayen_Epigenetics lab (@srimontagayen)
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For all DNA repair and mutagenesis enthusiasts: the 7th edition of Fundamental Aspects of DNA Repair and Mutagenesis (VII FARM-DNA) is coming!🧬🛠 Registrations are open until July 31! To register and submit your abstract, visit: farmdna2025.com.br/ See you there! 😉
Image from ASG DNA MoVINg (@DNAMoving)
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Join us for the next EDRA webinar. Jessica Downs will discuss on SWI/SNF at G-quadruplexes, Yasmina Djeghmoum on transcription as a regulator of HR, and Sree Rama Chaitanya on BRCA2 variants and their effects on chromatin and transcription. Don’t miss it! dnarep.sciencesconf.org/reso…
Image from EDRA (European DNA Repair Alliance) (@EDRA_Webinars)
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Pierre Caron retweeted
preLights (@preLights) profile picture
preLights@preLights5 Jun 2025
First preLights post from Jenny Singh (@jennysingh91) She covers work showing that Lamin A/C maintains replication fork integrity during mild replication stress by modulating chromatin structure and restraining RECQ1 activity. #preprint #preLight ⬇️👀 prelights.biologists.com/hig…
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3...

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3...

Lamin A/C maintains replication fork integrity during mild replication stress by modulating chromatin structure and restraining RECQ1 activity.

prelights.biologists.com
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#IBSevents: Séminaire Grand Public le 24/06 à 10h30 par Juan Carlos Fontecilla-Camps, intitulé "L’histoire évolutive de nos cellules, obéissance ou collaboration ?": urls.fr/Jnov8U
Image from Institut de Biologie Structurale (@IBS_Grenoble)
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Many thanks to the 2025 Organizing Committee who made this scientific day a success! The event ended with a potluck diner and musical entertainment provided by a group of IBS students. Here is a photo story of this annual event!
Image from Institut de Biologie Structurale (@IBS_Grenoble)
Image from Institut de Biologie Structurale (@IBS_Grenoble)
Image from Institut de Biologie Structurale (@IBS_Grenoble)
Image from Institut de Biologie Structurale (@IBS_Grenoble)
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#Thread: The flash/poster Prize was awarded to Maria Val Pevida (M&P group @IBS_Grenoble) who is seeking to decipher the molecular mechanism of activation of NADPH oxidase complex NOX1 by cryogenic electron microscopy.
Image from Institut de Biologie Structurale (@IBS_Grenoble)
Image from Institut de Biologie Structurale (@IBS_Grenoble)
Image from Institut de Biologie Structurale (@IBS_Grenoble)
Image from Institut de Biologie Structurale (@IBS_Grenoble)
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Last week, I presented the last results of my PhD at the main conference of Computational Biology in Brazil, X-meeting!!! 💻🧬 We have analyzed comparatively DNA repair genes from Antarctic samples coming from both surface and deep-sea sediments! Next step: finish the PhD! 🤪
Image from Rayana Feltrin 👩🏽‍💻🧬 (@rayomics)
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