“Apoptotic cell overload drives multinucleated giant cell formation after neoadjuvant chemotherapy in colorectal cancer: molecular mechanisms and tumor-suppressive effects” A link between therapy-induced #CellDeath and anti-tumor myeloid remodeling ⤵️ nature.com/articles/s41419-0…

“Fhl2 promotes chondrocyte ferroptosis in osteoarthritis by impairing mitophagic flux through microtubule disorganization” Targeting these pathways may offer new strategies to limit #Ferroptosis-associated cartilage loss in #Osteoarthritis ⤵️ nature.com/articles/s41418-0…

“Chidamide induces ROS-driven ZAKα-dependent ribotoxic stress in endometrial cancer and enhances radiosensitivity in vitro and in vivo” This work supports further development of chidamide-based strategies for high-risk #EndometrialCancer ⤵️ nature.com/articles/s41419-0…

“Glutamine synthesis pathway promotes the survival and recurrence of dormant tumor cells in prostate cancer” This work suggests that the combination of #HormonalTherapy and GS inhibitors may overcome therapeutic #Resistance ⤵️ nature.com/articles/s41420-0…

“The NEK8/ALYREF axis promotes cisplatin resistance in bladder cancer by stabilizing CDK18 mRNA to facilitate DNA damage repair” Targeting the NEK8/ALYREF/CDK18 axis may offer a potential strategy to overcome #Chemotherapy resistance in #BCa ⤵️ nature.com/articles/s41418-0…

“Targeting FEN1 disrupts EIF4A3-mediated MUC1-C autoregulation: a novel strategy to suppress lung adenocarcinoma progression” These findings unravel the dual role of FEN1 in regulating #LUAD cell malignancy and tumor #Immunity ⤵️ nature.com/articles/s41419-0…

“A chemical-genetic system for calreticulin exposure on cancer cells reveals immune-dependent antitumor effects” Can calreticulin exposure alone drive anticancer #Immunity? ⤵️ nature.com/articles/s41418-0…

"USP25 augments XIAP-mediated signaling to safeguard intestinal homeostasis" This work reveals the relationship between USP25 and XIAP and provides new insights into the pathogenesis of #IBD ⤵️ nature.com/articles/s41418-0…

“Ubiquitination of LMP-1 by UFD-2 regulates apoptotic cell clearance” These findings expand our understanding of ubiquitin-dependent control of #Efferocytosis ⤵️ nature.com/articles/s41418-0…

“CDC73 suppresses lung adenocarcinoma via the PTEN/AKT pathway and exhibits biomarker and functional potential in extracellular vesicles” A promising target and #Biomarker for early-stage #LUAD ⤵️ nature.com/articles/s41420-0…

“p53 wild-type/low c-Myc-expressing ONS76 pediatric medulloblastoma cells become senescent after gamma-irradiation and can be eliminated by senolytic substances” Translating these findings to the clinic could potentially benefit the oncological outcome ⤵️ nature.com/articles/s41420-0…

“Targeting common denominators of DNA damage tolerance mechanisms as therapeutic strategy to cope with dynamic phenotypic changes in triple-negative breast cancer cells” DDT pathway components as exploitable vulnerabilities of #TNBC cells ⤵️ nature.com/articles/s41420-0…

“JP-1302 inhibits RNA polymerase I transcription and induces nucleolar stress in cancer cell lines” A pharmacologically distinct inhibitor of ribosome biogenesis with broader, dose-dependent chromatin-disruptive activity ⤵️ nature.com/articles/s41420-0…

“Chondroitin sulfate shapes the unfolded protein response in osteosarcoma to sustain cancer cell survival during ER stress” Read more about the regulatory and functional relationships between oncofetal CS and #ERStress in #Osteosarcoma ⤵️ nature.com/articles/s41419-0…

“nHOTAIRM1 scaffolds ANXA11-dependent assemblies to drive axonal mRNA localization in human motor neurons” How do #neurons deliver specific mRNAs to distant axons? @RNAlab_IBPM uncovered how a #lncRNA can regulate mRNA sorting in human #spMNs ⤵️ nature.com/articles/s41418-0…

Explore our October issue: nature.com/cdd/volumes/33/is…

🎗️ Liver Cancer Awareness Month 🎗️ Browse our collection of research papers focused on liver cancer in: Cell Death & Disease nature.com/subjects/liver-ca… Cell Death Discovery nature.com/subjects/liver-ca… #LiverCancer #CancerResearch

“Anthracycline and antimetabolite, trigger distinct resistance mechanisms in TP53mut AML” Read this latest Correspondence in Cell Death Discovery ⤵️ nature.com/articles/s41420-0…