@cddpress

SCIENTIFIC JOURNAL group by @SpringerNature Cell Death & Differentiation, Death & Disease, Cell Death Discovery https://xitter.cf/t.co/fO56nMEUiJ

Joined July 2016
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“Glutamine synthesis pathway promotes the survival and recurrence of dormant tumor cells in prostate cancer” This work suggests that the combination of #HormonalTherapy and GS inhibitors may overcome therapeutic #Resistance ⤵️ nature.com/articles/s41420-0…
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“The NEK8/ALYREF axis promotes cisplatin resistance in bladder cancer by stabilizing CDK18 mRNA to facilitate DNA damage repair” Targeting the NEK8/ALYREF/CDK18 axis may offer a potential strategy to overcome #Chemotherapy resistance in #BCa ⤵️ nature.com/articles/s41418-0…
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“Targeting FEN1 disrupts EIF4A3-mediated MUC1-C autoregulation: a novel strategy to suppress lung adenocarcinoma progression” These findings unravel the dual role of FEN1 in regulating #LUAD cell malignancy and tumor #Immunity ⤵️ nature.com/articles/s41419-0…
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“A chemical-genetic system for calreticulin exposure on cancer cells reveals immune-dependent antitumor effects” Can calreticulin exposure alone drive anticancer #Immunity? ⤵️ nature.com/articles/s41418-0…
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"USP25 augments XIAP-mediated signaling to safeguard intestinal homeostasis" This work reveals the relationship between USP25 and XIAP and provides new insights into the pathogenesis of #IBD ⤵️ nature.com/articles/s41418-0…
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“Ubiquitination of LMP-1 by UFD-2 regulates apoptotic cell clearance” These findings expand our understanding of ubiquitin-dependent control of #Efferocytosis ⤵️ nature.com/articles/s41418-0…
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“CDC73 suppresses lung adenocarcinoma via the PTEN/AKT pathway and exhibits biomarker and functional potential in extracellular vesicles” A promising target and #Biomarker for early-stage #LUAD ⤵️ nature.com/articles/s41420-0…
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CDD press retweeted
CDD press@cddpressSep 24
🌏International Cell Death Seminar Series - Edition #2🌏 Details: 📅Date: Wednesday 14th October  🕰️Time: 4:30pm AEDT / 8:30am CEST 💻Webinar link: lnkd.in/erx2zZAN See the flyer below for more information ⤵️
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“p53 wild-type/low c-Myc-expressing ONS76 pediatric medulloblastoma cells become senescent after gamma-irradiation and can be eliminated by senolytic substances” Translating these findings to the clinic could potentially benefit the oncological outcome ⤵️ nature.com/articles/s41420-0…
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“Targeting common denominators of DNA damage tolerance mechanisms as therapeutic strategy to cope with dynamic phenotypic changes in triple-negative breast cancer cells” DDT pathway components as exploitable vulnerabilities of #TNBC cells ⤵️ nature.com/articles/s41420-0…
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“JP-1302 inhibits RNA polymerase I transcription and induces nucleolar stress in cancer cell lines” A pharmacologically distinct inhibitor of ribosome biogenesis with broader, dose-dependent chromatin-disruptive activity ⤵️ nature.com/articles/s41420-0…
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“Chondroitin sulfate shapes the unfolded protein response in osteosarcoma to sustain cancer cell survival during ER stress” Read more about the regulatory and functional relationships between oncofetal CS and #ERStress in #Osteosarcoma ⤵️ nature.com/articles/s41419-0…
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“nHOTAIRM1 scaffolds ANXA11-dependent assemblies to drive axonal mRNA localization in human motor neurons” How do #neurons deliver specific mRNAs to distant axons? @RNAlab_IBPM uncovered how a #lncRNA can regulate mRNA sorting in human #spMNs ⤵️ nature.com/articles/s41418-0…
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Explore our October issue: nature.com/cdd/volumes/33/is…
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nature.com/articles/s41420-0…. Happy to see our work published in @cddpress. We show that JP-1302, a BBB-penetrant α2C-adrenergic receptor antagonist, inhibits rRNA synthesis at low concentrations, while engaging TOP2 and broader chromatin-disruptive mechanisms at higher doses!

JP-1302 inhibits RNA polymerase I transcription and induces nucleolar stress in cancer cell lines

Cell Death Discovery - JP-1302 inhibits RNA polymerase I transcription and induces nucleolar stress in cancer cell lines

nature.com
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🎗️ Liver Cancer Awareness Month 🎗️ Browse our collection of research papers focused on liver cancer in: Cell Death & Disease nature.com/subjects/liver-ca… Cell Death Discovery nature.com/subjects/liver-ca… #LiverCancer #CancerResearch
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“Anthracycline and antimetabolite, trigger distinct resistance mechanisms in TP53mut AML” Read this latest Correspondence in Cell Death Discovery ⤵️ nature.com/articles/s41420-0…
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🎗️ Breast Cancer Awareness Month 🎗️ Access our updated collection of breast cancer-related research papers in: Cell Death & Disease nature.com/subjects/breast-c… Cell Death Discovery nature.com/subjects/breast-c… #BreastCancer #BreastCancerAwarenessMonth #CancerResearch
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CDD press retweeted
Ivano Amelio@ivanoamelioOct 1
And at Cell Death Discovery (@CDDpress), we are also interested in sharing high-quality research that has led to negative results. If you have rigorous and informative findings that deserve visibility, please reach out.
Prof. Nikolai Slavov
@slavov_nSep 30
bioRxiv has a dedicated section for negative results. Use it. Share negative results. Your colleagues will appreciate it.
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“Efferocytosis triggered proteomic reprogramming of macrophages reveals CD97 as a novel apoptotic receptor” @drbenraymond & @TrostLab identified CD97 as a novel #Efferocytosis-associated protein ⤵️ nature.com/articles/s41418-0…
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