@CellRepMethods

A new multi-disciplinary, gold #OA journal from @CellPressNews publishing cutting-edge methodological advances.

cell.com/cell-reports-methods/home
Joined November 2020
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139Media
Apus enables automated end-to-end analysis and quality control of large-cohort proteomics data dlvr.​it/TVwyR8
142
A dataset of differentiable biologically derived single-neuron models dlvr.​it/TVw9pm
112
Acute in vivo proximity labeling for membrane-targeted proteomics in neuronal circuits dlvr.​it/TVtc9f
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932
Automated cross-session ROI tracking for multicellular calcium imaging with OPTIC dlvr.​it/TVpQgp
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768
Mycobacterium tuberculosis gene expression dynamics in host environments with single-cell resolution dlvr.​it/TVngyd
145
High-throughput, amplification-free detection of endogenous gene expression perturbations via fluorescence anisotropy dlvr.​it/TVnbK8
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454
In vivo electrophysiology in head-fixed and freely moving mole-rats dlvr.​it/TVkljc
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15
1,712
stFormer integrates spatial ligand signaling into a foundation model for spatial transcriptomics dlvr.​it/TVjr33
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SurpHer: A genetically encoded ratiometric biosensor for dynamic extracellular pH imaging dlvr.it/TVj0J8

SurpHer: A genetically encoded ratiometric biosensor for dynamic extracellular pH imaging

Holste, Dos Santos, et al. develop SurpHer, a genetically encoded ratiometric biosensor for imaging extracellular pH at the surface of living cells. Through modular screening, they develop a membra...

cell.com
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23
2,323
A single ROSA26 mouse line for robust tdTomato labeling with Cre, FLP, Dre, Vika, SCre, and VCre recombinases dlvr.it/TVhFZL

A single ROSA26 mouse line for robust tdTomato labeling with Cre, FLP, Dre, Vika, SCre, and VCre...

Nakashiba et al. engineer a multi-recombinase reporter mouse line, ROSA26-6R, consolidating responsiveness to six recombinases into a single locus. This platform minimizes colony management effort...

cell.com
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63
7,821
Self-supervised missing-wedge correction enables accurate cellular morphology and volume reconstruction in soft X-ray tomography dlvr.it/TVh8lh

Self-supervised missing-wedge correction enables accurate cellular morphology and volume reconstr...

Chueh et al. present a self-supervised sinogram inpainting framework to correct missing-wedge artifacts in soft X-ray tomography. By recovering unrecorded projection angles without ground-truth data,...

cell.com
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739
Intravital 3-photon microscopy of leukocyte dynamics in the splenic white pulp dlvr.it/TVfHPL

Intravital 3-photon microscopy of leukocyte dynamics in the splenic white pulp

Schienstock et al. present a technical framework using surgical preparation of the mouse spleen, intravital 3-photon microscopy, and quantitative image analysis to interrogate in vivo leukocyte...

cell.com
224
A knockin Ntsr1Flp driver enables intersectional and systemic targeting of heterogeneous midbrain dopamine circuits dlvr.it/TVdYqV

A knockin Ntsr1Flp driver enables intersectional and systemic targeting of heterogeneous midbrain...

Garcia et al. develop intersectional viral-genetic approaches to access molecularly overlapping dopamine and non-dopaminergic neuron subtypes in the mouse midbrain. Their strategy enables selective...

cell.com
1
195
A single-cell spatiotemporal manifold of tissue morphology and dynamics dlvr.it/TVdSpG

A single-cell spatiotemporal manifold of tissue morphology and dynamics

Haus et al. create a learned, embedding-based representation of cell position in developing embryos. Embeddings describe dynamic morphology at the single-cell level, enabling applications in identi...

cell.com
1
189
HisTrader identifies nucleosome-free regions within ChIP-based profiling of histone post-translational modifications dlvr.it/TVY5Lx

HisTrader identifies nucleosome-free regions within ChIP-based profiling of histone post-translat...

Kirbizakis et al. develop HisTrader, a tool that pinpoints the short stretches of accessible DNA, where regulatory proteins bind, from widely available histone modification data. HisTrader enables...

cell.com
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4
279
Revealing therapeutic single-cell transcriptomic signatures using a simple classifier dlvr.it/TVY0pm

Revealing therapeutic single-cell transcriptomic signatures using a simple classifier

Gene-expression-based drug screening usually requires at least 50–100 copies of the same clone or cells treated in the same way. Ma et al. describe a single-cell analysis platform that enables the...

cell.com
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200
Development and application of nbLIBRA-seq for high-throughput discovery of antigen-specific nanobodies dlvr.it/TVXFNM

Development and application of nbLIBRA-seq for high-throughput discovery of antigen-specific...

Leonard et al. present LIBRA-seq for nanobody discovery (nbLIBRA-seq), a method for rapidly screening and discovering antigen-specific nanobodies in alpaca. The approach increases the throughput and...

cell.com
1
1
228
Moving beyond linear summation to infer interaction order from neural and biological dynamics dlvr.it/TVX84q

Moving beyond linear summation to infer interaction order from neural and biological dynamics

Biological networks can involve interactions among more than two components, but detecting them from dynamics is difficult. Altshuler et al. introduce a recurrent network framework that compares...

cell.com
171
Self-amplifying RNA enables rapid, durable, integration-free programming of hiPSCs dlvr.it/TVWHCk

Self-amplifying RNA enables rapid, durable, integration-free programming of hiPSCs

Self-amplifying RNAs (saRNAs) have the potential for rapid, durable, non-integrating delivery of transgenes in human induced pluripotent stem cells. Della Santina et al. show that transcription...

cell.com
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6,155
Parallelized bright-field and fluorescence imaging platform for organoids dlvr.it/TVVNYp

Parallelized bright-field and fluorescence imaging platform for organoids

Kim et al. present a multi-camera array scanner (MCAS) that uses 48 parallel lenses to image organoids. The MCAS reduces acquisition time by 98% compared to commercial systems. The platform enables...

cell.com
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