Lukas Cermak Lab (@CermakLab) header
Lukas Cermak Lab (@CermakLab) profile picture

Lukas Cermak Lab

@CermakLab

We want to be there when protein is broken down and cullins are present. #ubiquitin #ubiquitin_ligases #mouse_models

 Prague
Joined May 2022
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  • Followers235
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Photo by Lukas Cermak Lab (@CermakLab)Photo by Lukas Cermak Lab (@CermakLab)Photo by Lukas Cermak Lab (@CermakLab)Photo by Lukas Cermak Lab (@CermakLab)
Excited to share our discovery: CRL4-DCAF12 regulates DNA replication by ensuring proper nascent MCM2-7 complex assembly. This prevents genome instability and diseases like cancer.🙏Big thanks to @HanaSedlackova1 for the great collaboration! biorxiv.org/content/10.1101/…
CRL4DCAF12 regulation of MCMBP ensures optimal licensing of DNA replication

CRL4DCAF12 regulation of MCMBP ensures optimal licensing of DNA replication

The minichromosome maintenance (MCM2-7) protein complexes are central drivers of genome duplication. Distinct protein pools, parental and nascent MCMs, and their precise equilibrium are essential to...

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📢 Happy to share our bioRxiv preprint on how CRL4-DCAF12 regulates the cellular level of MCMBP, a chaperone of nascent MCM2-7 complexes, to ensure error-free genome duplication. The full story can be found here: lnkd.in/eCjVNQks
Image from Hana Sedlackova (@HanaSedlackova1)
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Lukas Cermak Lab retweeted
michele pagano (@paganolab) profile picture
michele pagano@paganolab5 Nov 2024
now published on line @CellCellPress sciencedirect.com/science/ar…
ZhengLab (@LabZheng) profile pictureZhengLab@LabZheng4 Jun 2024
Together with Michele Pagano's lab at NYU, we are excited to share a new story on two F-box protein E3 ligases recognizing two distinct & mutually exclusive degrons encrypted in the quaternary structure of the substrate protein biorxiv.org/content/10.1101/…
Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under...

Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under...

The transcription factor BACH1 regulates heme homeostasis and oxidative stress responses and promotes cancer metastasis upon aberrant accumulation. Its stability is controlled by two F-box protein...

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CRL4-DCAF12 fine-tunes replication by degrading MCMBP, enabling proper MCM assembly and accurate replication speed. Without it? Faster forks, DNA damage, instability—and a cancer risk.
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Huge congrats to @yadav_anoop101, @aabdirov1, and @KatarinaOndrusk for their fantastic contributions to this elegant study! @imgprague @BFUavcr @CzechAcademy #DNAreplication #CancerResearch #proteasome #ubiquitin
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What a wonderful, inspiring, and collaborative meeting at #EMBOubiquitin2024! In 1998, I attended my first conference—same #Cavtat, same @iDikic2. Huge thanks to the organizers @YMerbl, @YKulathu, @LabJoazeiro, @polosimona1, and @EMBOevents!
Image from Lukas Cermak Lab (@CermakLab)
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Fantastic work by @NikolDibus and an excellent collaboration with Michele Pagano @paganolab and Ondrej Stepanek @AdaptiveImmuni2! Hopefully, more journals will endorse papers focused on addressing the confusion published across all levels. embopress.org/doi/full/10.10…
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🔬 Join our research team! 🎓 Explore the vital role of the proteasome in cancer cell apoptosis. 🧬Seeking passionate PhD candidates in molecular biology. img.cas.cz/group/lukas-cerma… 🧪#PhDPosition #CancerResearch #MolecularBiology
Laboratory of Cancer Biology

Laboratory of Cancer Biology

 Regulation of the Wnt signalling pathway by the ubiquitin-proteasome system (UPS) We have reviewed the current understanding of how the UPS regulates the Wnt, TGF-β, and Notch signalling...

img.cas.cz
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Lukas Cermak Lab retweeted
michele pagano (@paganolab) profile picture
michele pagano@paganolab15 Jan 2024
Do papers improve after peer review? Only in a limited number of cases. Is it still worth the effort? Let’s eliminate the tyranny of peer review and publish only in BioRxiv. Is it too bold for @NIH to ask to use taxpayers’ money to perform research rather than enrich publishers?
Oded Rechavi (@OdedRechavi) profile pictureOded Rechavi
@OdedRechavi15 Jan 2024
Papers improve after peer review. Yes, probably. But I'd like to see, as a control, whether there'll be a comparable (or bigger) improvement if the editors just told the authors "work on it for additional 2 years and then resubmit".
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A postdoc position is available in our lab 🔬. If you are interested in DNA replication & genome stability, please get in touch. Thank you for sharing! More information also here: ibp.cz/en/offers/job-offer/p…
Image from Hana Sedlackova (@HanaSedlackova1)
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In between experiments... #freshblood
Image from Lukas Cermak Lab (@CermakLab)
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Great talk at @imgprague by Vincenzo D'Angiollella @VdangioE3lab on #neomorphic substrates and his own Cyclin F. It's always a blast to meet other Pagano lab @paganolab alumni.
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FBXO38 does not control PD-1 stability biorxiv.org/content/10.1101/…
FBXO38 does not control PD-1 stability

FBXO38 does not control PD-1 stability

SKP1-CUL1-F-box protein (SCF) ubiquitin ligases are versatile protein complexes that mediate the ubiquitination of substrates, which are recognized by their F-box-domain- containing subunits[1][1]....

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First author Nikol Dibus @NikolDibus had dedicated her doctoral life to FBXO38, so far the only CUL1-dependent substrate receptor mutated in a hereditary form of neuromuscular atrophy. I can see more great stories coming out about this unique ubiquitin ligase.
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Keep following us :)
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Lukas Cermak Lab retweeted
bioRxiv (@biorxivpreprint) profile picture
bioRxiv@biorxivpreprint21 Mar 2023
Matters Arising: FBXO38 does not control PD-1 stability biorxiv.org/cgi/content/shor… #bioRxiv
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Lukas Cermak Lab retweeted
michele pagano (@paganolab) profile picture
michele pagano@paganolab22 Mar 2023
SCF-FBXO38 does not control PD-1 stability biorxiv.org/content/10.1101/… 🧵 1/8
FBXO38 does not control PD-1 stability

FBXO38 does not control PD-1 stability

SKP1-CUL1-F-box protein (SCF) ubiquitin ligases are versatile protein complexes that mediate the ubiquitination of substrates, which are recognized by their F-box-domain- containing subunits[1][1]....

biorxiv.org
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Lukas Cermak Lab retweeted
Antonio Marzio (@_AntonioMarzio) profile picture
Antonio Marzio@_AntonioMarzio10 Oct 2022
🚨 📢 My lab is looking for a highly motivated Research Associate to join our team @WCMCPathology @WeillCornell ! Learn more about us at lnkd.in/e6nGUdwG. Spread the word!! linkedin.com/jobs/view/33098… 📢

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Lukas Cermak Lab retweeted
michele pagano (@paganolab) profile picture
michele pagano@paganolab5 Aug 2022
Just received more pics of the Retreat from various alumni. Why don't you move all back to NYC? 😪 At least @_AntonioMarzio will be @WCMCPathology, only 30 minutes walking distance from @nyulangone ...
Image from michele pagano (@paganolab)
Image from michele pagano (@paganolab)
Image from michele pagano (@paganolab)
Image from michele pagano (@paganolab)
michele pagano (@paganolab) profile picturemichele pagano@paganolab1 Aug 2022
The @paganolab retreat (current members + alumni from 5 continents) ended on Sunday afternoon. It was fun and the food (particularly, Saturday night at Capri) was great. We had two days of full immersion in the biology of CRLs following the @FASEBorg conference on #ubiquitin…
Image from michele pagano (@paganolab)
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