Excited to share our new paper, now online in OBC!
We report a propargyl uridine-based click chemistry strategy to access site-selectively glycosylated oligonucleotide analogues—useful glycoRNA mimics for structural and functional studies.
doi.org/10.1039/D6OB00597G @rsc_chembio
Can endogenous enzyme help control #CRISPR activity? In our new JOC article, we introduce nitroreductase-responsive oligomeric crRNAs for enzyme-triggered regulation of CRISPR activity, opening a strategy for hypoxia-associated settings. doi.org/10.1021/acs.joc.5c02… @ACSPublications
New in Advanced Materials: we built quinazoline-bridged COFs and show they enable selective photocatalytic sulfoxide synthesis from alkenes + thiols—highlighting how linkage chemistry tunes optoelectronics.
doi.org/10.1002/adma.2025236…
@advancematerial #COF #Photochemistry
Selective, site-specific RNA labeling—without the fuss. 🧬✨
In our new ChemBioChem article, we use tetrazine-based IEDDA to selectively modify allyl-functionalized RNA, with digestion confirming conjugation only at the allyl-modified site.
Read: chemistry-europe.onlinelibra…
Sequence-independent optical regulation of CRISPR/Cas editing using star-shaped crRNA dendrimers — a light-activated strategy enabling precise spatiotemporal control of CRISPR/Cas9 & Cas12a with minimal leakage. 🌟
doi.org/10.1039/D5CC06011G
@RoySocChem #CRISPR #GenomeEditing
🌱New Article in Adv. Agrochem.
“The capability of synthetic cytokinin mimics for in vitro regeneration of plants”
✨Synthetic cytokinin mimetics boost shoot & root growth
✨Potential tools for plant tissue culture & regeneration
📖 doi.org/10.1016/j.aac.2025.0…
🧬 New Review: Recent Advances in the Biological Functions of 5-Methyluridine (m⁵U) RNA Modification
👉 m⁵U: abundant, conserved, yet understudied
👉 Roles in tRNA stability, folding & translation
👉 Links to cancer, neurodegeneration & more
📖 Explore-> doi.org/10.6023/A25050152
🔥 Excited our paper is now a Hot Paper in @angew_chem ! @Wiley_Chemistry
Star-shaped crRNAs enable precise photo-controlled CRISPR/Cas editing in cells & in vivo. 🌟📸
👉 doi.org/10.1002/anie.2025065…
#CRISPR #GeneEditing #Photocontrol #AngewChem
RNA epigenetics meets chemical biology! Our review just published in Acc. Chem. Res. highlights purely chemical strategies to precisely control RNA modifications, impacting gene regulation and cellular function. Read 👉doi.org/10.1021/acs.accounts… @ACSPublications #RNA #Epigenetics
Excited to share that our collaborative article with Prof. Mark Helm, "A Direct Chemical Repair of Etheno-Type RNA Damages," has been published in Angewandte Chemie! 🎉 Cheers to the team! @AttheHelm3 @angew_chem @Wiley_Chemistry onlinelibrary.wiley.com/doi/…
Our recent work "A Live-Cell Epigenome Manipulation by Photo-Stimuli-Responsive Histone Methyltransferase Inhibitor" has been published on @AdvSciNews @Wiley_Chemistry onlinelibrary.wiley.com/doi/…
Our invited review "Advances in the Investigation of N6-Isopentenyl Adenosine i6A RNA Modification" has been published online at Bioorganic & Medicinal Chemistry in honor of Professor Chuan He @ELSchemistry @TetrahedronChem doi.org/10.1016/j.bmc.2024.1…
Our invited review "More than just Alkene Construction – Re-using Wittig Reactions/Reagents in Biomacromolecular Labeling, Imaging, Sequencing and Modification" at @AnalysisSensing @Wiley_Chemistry doi.org/10.1002/anse.2023000…
More than just Alkene Construction - Re-using Wittig Reactions/Reagents in Biomacromolecular Labeling, Imaging, Sequencing and Modification (Liang Cheng and co-workers) onlinelibrary.wiley.com/doi/…
Our most recent work "Discovery of Photoexcited 2-Chloro-3,5-Dinitrobenzoic Acid as a Chemical Deprenylase of i6A RNA" at @ChemBioChem as an VIP article!!! @Wiley_Chemistry doi.org/10.1002/cbic.2024003…
Our work "Total synthesis of all stereoisomers of C5-glyceryl-methyl-2'-deoxycytidine 5gmC and their occurrence in green alga Chlamydomonas reinhardtii" has finally been online @CellRepPhysSci #50YearsofCell doi.org/10.1016/j.xcrp.2024.…
Our work "A direct synthesis of 5-azidomethyl pyrimidine nucleosides via dehydroxyazidation" on Tetrahedron Letters @ELSchemistry #TetrahedronLetters doi.org/10.1016/j.tetlet.202…
