@ChrisFryPhD

Muscle and exercise biologist, avid gym goer and occasional amateur bodybuilder, husband and father, Professor, personal account

Joined June 2020
  • Tweets620
  • Following580
  • Followers2K
43Media
Christopher Fry retweeted
Kevin Murach@KevinMurachPhDOct 15
“A Hypertrophic Stimulus Drives Age-Dependent Transcript Isoform Switching With and Without Differential Gene Expression in Skeletal Muscle” by @PJKoopmansPhD w/@AhmedIsmaeelPhD @yuan_wen16220 and Nelson lab at U of A @AgingCell onlinelibrary.wiley.com/doi/… #myotwitter

A Hypertrophic Stimulus Drives Age‐Dependent Transcript Isoform Switching With and Without Differ...

A combined analysis of short-read and long-read RNA-seq demonstrates reduced isoform switching after an acute hypertrophic stimulus in aged muscle and identifies age-dependent isoforms that may not...

onlinelibrary.wiley.com
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Christopher Fry retweeted
Ahmed Ismaeel@AhmedIsmaeelPhDOct 1
Our new paper led by recently minted Dr. Burke is out now in @AJPCellPhys! Following up on recent work showing 'microbial-derived exerkines' prevent muscle atrophy, here we extend their utility to ENHANCING EXERCISE PERFORMANCE AND ADAPTATION. More below journals.physiology.org/doi/…

Microbial-derived exerkines outperform creatine monohydrate in enhancing skeletal muscle adaptation...

We recently demonstrated that the microbial-derived exerkines (MDEs) pipecolic acid and succinate (PAS) prevent disuse-induced skeletal muscle atrophy and preserve muscle function during hindlimb...

journals.physiology.org
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Christopher Fry retweeted
Abigail Mackey@AbigailMackey1Sep 28
Our latest (preprint): In young and older women💪, short-term prehabilitative exercise mitigates the consequences of limb immobilization by establishing greater muscle and strength reserve, rather than by attenuating the molecular responses to disuse. @ISMCopenhagen #myotwitter
Casper Søndenbroe@SoendenbroeSep 28
New preprint: "Prehabilitative Exercise Mitigates Immobilization-Induced Atrophy Through Muscle Reserve Rather Than Resistance to Disuse: The PRE-EX Randomized Controlled Trial" medrxiv.org/content/10.64898…

Prehabilitative Exercise Mitigates Immobilization-Induced Atrophy Through Muscle Reserve Rather...

Periods of limb immobilization are common in clinical care and lead to rapid losses of muscle mass and strength. We therefore examined whether prehabilitative exercise improves outcomes after disuse...

medrxiv.org
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Christopher Fry retweeted
The Hornberger Lab@HornbergerLabSep 26
Why do muscle fibres shrink with age? Not because myofibrils get smaller — because there are fewer of them. We followed this from whole-muscle down to individual myofibrils, in humans and mice, across ageing and disuse. Tweetorial below Open Access here: physoc.onlinelibrary.wiley.c…
The Hornberger Lab@HornbergerLabFeb 18
1/ Why do muscles atrophy with aging and disuse? Is it because each tiny little myofibril gets smaller… or is it because we lose myofibrils? In our new study, we addressed this in humans and mice. biorxiv.org/cgi/content/shor… Full breakdown of the findings in this thread 👇
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Can’t forget to shout out @rpwohlgemuth for Postdoc appreciation week! Whether chilling in the cold room or dominating on the court, we (I) appreciate all you do for the lab
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Excited to read this one
Marcas Bamman, PhD@MarcasBammanSep 25
Spatial Transcriptomics Identifies Muscle Inflammation Susceptibility as a Distinct Periarticular Skeletal Muscle Phenotype in End-Stage Knee Osteoarthritis biorxiv.org/content/10.64898…

Spatial Transcriptomics Identifies Muscle Inflammation Susceptibility as a Distinct Periarticular...

Skeletal muscle dysfunction is a major contributor to disability and incomplete functional recovery in patients with end-stage knee osteoarthritis (KOA), yet the spatial components of disease-assoc...

biorxiv.org
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Christopher Fry retweeted
Kevin Murach@KevinMurachPhDSep 22
“Exercise preconditioning confers skeletal muscle myometaplasticity”. biorxiv.org/content/10.64898… #myotwitter

Exercise preconditioning confers skeletal muscle myometaplasticity

Previously exercise trained skeletal muscle is more growth-responsive to retraining. Using a murine training-detraining-retraining approach and multi-omics, we find that Pecam1 gene expression is...

biorxiv.org
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Christopher Fry retweeted
Journal of Physiology@JPhysiolSep 17
'Treating #age-related loss of #muscle mass and function: Where should we be focusing?' Following their presentation at AuPS 2025, Daniel J. Ham (@biozentrum) and co-authors examine what treatments for age-related muscle wasting should target 🔎 🎯 buff.ly/z6FvycY
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An ACL tear can affect more than the knee. New research in @APS_Function links immune cells stuck in a dysfunctional state to thigh muscle loss & post-injury arthritis, suggesting a new treatment target: ow.ly/cKvz50ZM3Lg #ArticlesInPress #APSselect #ACLInjury 📷: @iStock
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Congrats Nicky T and Mikaela! Great @UKYCMB turnout for the @NickTThomas wedding. @FryDiet @saragonzalezve @rpwohlgemuth @yuan_wen16220 @Allison_M_Owen
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Christopher Fry retweeted
Nick Thomas@NickTThomasAug 28
Very excited to share our latest project detailing the transcriptional fate of satellite cell derived myonuclei in adult and aged muscle! biorxiv.org/content/10.64898… Jensen Goh, @KevinMurachPhD @ChrisFryPhD Char Peterson @AhmedIsmaeelPhD @jjmcca2_john @yuan_wen16220
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An indispensable tool in our lab; we’ll be collecting data on it tomorrow :-)
Aurora Scientific@AuroraSciAug 26
What if studying murine quadriceps function in vivo looked like a leg extension at the gym? Our latest technical blog, developed from a collaboration with Dr. @ChrisFryPhD's Lab, explores this approach. Read it now: aurorascientific.com/a-guide… #MusclePhysiology #Orthopaedics
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Congrats @miadobis1 and @EsbenSchroeder on your white coat ceremony! So excited for your grad school journey to begin
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Great to see the final version of this paper, thanks to @APSPhysiology and @APS_Function for highlighting our work!
Function@APS_FunctionAug 14
Researchers find increased senescent #macrophage burden in muscle & #knee in preclinical #ACL injury model, and provide evidence that treatment with #senolytics is an effective strategy to mitigate posttraumatic #osteoarthritis severity. ow.ly/VpoN50ZzPlR
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Christopher Fry retweeted
Kevin Murach@KevinMurachPhDAug 10
Really great physician scientist opportunity here at @OMRF!!!
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A great study from @NickTThomas’s dissertation defining a rapid and coordinated myonuclear epigenetic and transcriptomic response to ACL injury in mice. Great work Nick!
Nick Thomas@NickTThomasJul 15
Very excited to share our paper showing altered myonuclear epigenetics and transcriptional output in response to ACL injury! Out now in @BioMedCentral Molecular Medicine! doi.org/10.1186/s10020-026-0… Thankful to work with an awesome crew! @ChrisFryPhD @KevinMurachPhD @yuan_wen16220

ACL injury reprograms quadriceps myonuclear epigenetic and transcriptional signatures in mice

Molecular Medicine - ACL injury is a debilitating sport-related injury that induces prolonged deficits in muscle size and strength. Using a time-course of in vivo fluorescent metabolic labeling of...

link.springer.com
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Christopher Fry retweeted
Kevin Murach@KevinMurachPhDJul 15
“Myonuclear dynamics after skeletal muscle surgical injury” by undergrad Micah Goeke along with Drs. @PJKoopmansPhD and Nate Serrano. Seems like those non satellite cell-derived myonuclei are more active than we realize. #myotwitter faseb.onlinelibrary.wiley.co…

Myonuclear Dynamics After Skeletal Muscle Surgical Injury

Using a recombination-independent doxycycline inducible model of timed nonsatellite cell-derived myonuclear labeling in adult skeletal muscle, we show that resident myonuclei move and become displa...

faseb.onlinelibrary.wiley.com
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Christopher Fry retweeted
Ahmed Ismaeel@AhmedIsmaeelPhDJul 10
So excited to see this out in @NatureComms! Led by soon-to-be Dr., Benjamin Burke, and the one who started it all-Dr.Taylor Valentino. @jjmcca2_john @yuan_wen16220 @UKYCMB nature.com/articles/s41467-0…

Exercise-associated microbial metabolites prevent skeletal muscle atrophy in adult female mice

Nature Communications - The gut microbiome from exercise-trained mice protects against muscle atrophy when transferred to immobilized mice. Two microbial metabolites, pipecolic acid and succinate,...

nature.com
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Christopher Fry retweeted
Kevin Murach@KevinMurachPhDJul 10
Congrats to @UKYCMB on this absolute banger! “Exercise-associated microbial metabolites prevent skeletal muscle atrophy in adult female mice” #myotwitter nature.com/articles/s41467-0…

Exercise-associated microbial metabolites prevent skeletal muscle atrophy in adult female mice

Nature Communications - The gut microbiome from exercise-trained mice protects against muscle atrophy when transferred to immobilized mice. Two microbial metabolites, pipecolic acid and succinate,...

nature.com
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Christopher Fry retweeted
Kevin Murach@KevinMurachPhDJun 30
Carried by Dr. @RonaldGJones3, “the gigaMYC paper” as the trainees call it: “Transient MYC Mimicking the Exercise Response Orchestrates Multifaceted Skeletal Muscle Adaptations”. A huge collab that started many many years ago. Too many to thank! biorxiv.org/content/10.64898…

Transient MYC Mimicking the Exercise Response Orchestrates Multifaceted Skeletal Muscle Adaptations

Despite decades of study, MYC’s physiological role in adult tissues remains obscured by the models used to investigate it. Most work relies almost exclusively on chronic or constitutive MYC induction...

biorxiv.org
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