@ChromDyn

Chromosome Dynamics group @CNIOStopCancer

 Madrid, Spain
tinyurl.com/ChromDyn
Joined October 2021
  • Tweets24
  • Following168
  • Followers381
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(1/6) NIPBL is required to fuel loop extrusion by cohesin. Is it also required for cohesin loading? We explore this question in a new preprint from the Losada Lab at @CNIOStopCancer posted in BioRxiv biorxiv.org/content/10.1101/…

Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2

Cohesin organizes the genome through the formation of chromatin loops. NIPBL activates cohesin’s ATPase and is essential for loop extrusion, but its requirement for cohesin loading is currently...

biorxiv.org
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New article from the lab: cell.com/cell-reports/fullte… A brief, 6-tweet summary follows (1/6)

A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-dif...

Ubieto-Capella et al. report that MRE11 nuclease is enriched at replication forks during primed-to-naive mESC transition and is responsible for replication fork slowdown. Inhibition of MRE11 exonuc...

cell.com
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Last two days to apply and join the lab as postdoc fellow! #singlecell #3Dgenome #enhancer #plasticity #glioblastoma #cancerneuroscience
@remeseiro-lab.bsky.social@Remeseiro_Lab12 Dec 2023
📢 2-year postdoc position!! Join us @Remeseiro_Lab to study #3DGenomics & #CellularPlasticity in #Glioblastoma #CancerNeuroscience. If you have background in #singlecell #omics and/or #bioinformatics, you're a good match to our team. Apply now 👇👇 Please RT RT RT 🤗
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📢 2-year postdoc position!! Join us @Remeseiro_Lab to study #3DGenomics & #CellularPlasticity in #Glioblastoma #CancerNeuroscience. If you have background in #singlecell #omics and/or #bioinformatics, you're a good match to our team. Apply now 👇👇 Please RT RT RT 🤗
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Tomorrow and invited by Ana Losada, @ChromDyn, Oscar Martinez will be at #CNIOStopCancer to speak about multi-omic approach to decipher the molecular mechanisms associated to #EwingSarcoma metastasis using a spontaneous metastasis mouse model. 👏Looking forward to it!
Oscar Martinez@omt200711 Sep 2023
If you want to learn a little bit about #metastasis on #ewingsarcoma stop by @CNIOStopCancer at 3 PM. I'll be explaining our latests results to understand this process. You are invited!! #research #curesarcoma #childhoodcancer @idibell_cat @ASEICAnews
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We are hiring!!!! 📢 We offer a 4-year FPI fellowship to work on Cohesin and 3D genome organization at @CNIOStopCancer. Please send your CV and a motivation letter to [email protected]
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How is DNA packaged inside cells? The third dimension of the genome may harbor new cancer treatments. #CFM_Genome
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We have been thinking a lot about NIPBL and cohesin lately…🤔
Trends Cell Biology@TrendsCellBio17 Apr 2023
NIPBL and cohesin: new take on a classic tale dlvr.it/SmdjWN

NIPBL and cohesin: new take on a classic tale

Cohesin is an evolutionarily conserved complex that belongs to the Structural Maintenance of Chromosomes (SMC; see Glossary) family. It comprises the heterodimer of SMC1 and SMC3, the kleisin subunit...

cell.com
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👉Third session #CFM_Genome about genome dynamic and stability. 👥With: @davegilbert19, from @SanDiegoBiomed and @marieprioleau from @IJMonod. 📋Inscriptions: bit.ly/3JhDqjc
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Finally out in @NatureComms!🥳 Is NIPBL required for cohesin loading in mammalian cells? Why do STAG1 and STAG2 cohesin complexes respond to NIPBL KD in opposite ways? Satisfy your curiosity in nature.com/articles/s41467-0…
Losada Lab@ChromDyn1 Dec 2022
(1/6) NIPBL is required to fuel loop extrusion by cohesin. Is it also required for cohesin loading? We explore this question in a new preprint from the Losada Lab at @CNIOStopCancer posted in BioRxiv biorxiv.org/content/10.1101/…

Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2

Cohesin organizes the genome through the formation of chromatin loops. NIPBL activates cohesin’s ATPase and is essential for loop extrusion, but its requirement for cohesin loading is currently...

biorxiv.org
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Congrats to everyone involved👏 @dacil_ag, @Cuadrado4Ana, @DanielGLL_ and Miriam Rodriguez! @CNIOStopCancer
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Losada Lab retweeted
Pisani Lab@PisaniLab2 Mar 2023
The website of the Cohesinet MSCA Doctoral Network is now ready !!! Check out it for more info about our consortium and 12 PhD positions available to study cohesin biology and related diseases. Do not miss this opportunity. Deadline is on 1st of April. cohesinet.eu
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(5/6) We propose a new model in which cohesin does not need NIPBL for chromatin association but it does for loop extrusion. While cohesin-STAG1 binds at CTCF sites and becomes stabilized rapidly, cohesin-STAG2 bind elsewhere and require NIPBL in order to reach CTCF positions.
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(6/6) Great work led by Dácil Alonso Gil @dacil_ag with major contributions from Ana Cuadrado @Cuadrado4Ana, Daniel Giménez Llorente @DanielGLL_ and Miriam Rodríguez Corsino.
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🧬Check out our latest contribution to current understanding of cohesin dynamics. A joint effort from past and current group members! @CNIOStopCancer epigeneticsandchromatin.biom…

Contribution of variant subunits and associated factors to genome-wide distribution and dynamics of...

Epigenetics & Chromatin - The cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There are two different cohesin complexes in...

link.springer.com
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Happy to see it out!! Fantastic collab with @MigManzanares lab, great work led by @MajoAndreu 👏👏
Manzanares lab@MigManzanares18 Oct 2022
New paper from @MigManzanares lab @CBMSO_CSIC_UAM out today in @CellReports! Together with Ana Losada’s lab @ChromDyn @CNIOStopCancer and led by @MajoAndreu, we studied CTCF in early mouse development (cell.com/cell-reports/fullte…) 1/n
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New paper from @MigManzanares lab @CBMSO_CSIC_UAM out today in @CellReports! Together with Ana Losada’s lab @ChromDyn @CNIOStopCancer and led by @MajoAndreu, we studied CTCF in early mouse development (cell.com/cell-reports/fullte…) 1/n
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