Assistant Professor at #BNI Phoenix. Multiple Sclerosis and myeloid cells maniac.
St. Louis
Joined July 2009
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We identify FKBP5 as a key regulator of myeloid-driven neuroinflammation in #MS
🔬 Elevated in CSF monocytes & microglia from MS
🧬 Inhibition boosts myelin clearance & reduces IFNγ signaling
🐭 SAFit2 improves EAE outcomes
#JournalofNeuroinflammation
rdcu.be/e3zGN
Claudia Cantoni retweeted
50 years after the publication of The Selfish Gene, it's time for books that capture the complexity of life to take centre stage
go.nature.com/4dXkdlX
Claudia Cantoni retweeted
New online! Use of animal models to understand CNS neuroimmunology — guidance from the International Society for Neuroimmunology White Paper Task Force dlvr.it/TW3nN5
Claudia Cantoni retweeted
Chronic progressive demyelination induces a microglial state with lysosomal dysfunction @NatureNeuro
nature.com/articles/s41593-0…
Claudia Cantoni retweeted
Dysregulated cholesterol trafficking through ABCA1 drives neurodegeneration in Parkinson’s disease @NatureNeuro nature.com/articles/s41593-0…
Claudia Cantoni retweeted
A new study found that NAD+ levels in whole blood stay surprisingly stable throughout adulthood. So why are scientists still studying NAD+? Learn more from Lifespan Magazine 📚️ lifespan.com/blogs/magazine/…
Claudia Cantoni retweeted
Mice engineered to overexpress klotho lived 20–30% longer with no signs of illness doi.org/10.1126/science.1112…
Claudia Cantoni retweeted
"Prior mental illness...was associated with an increased risk of active mental illness during a second pregnancy. One in four mothers with MS required mental health care...during the second pregnancy." doi.org/10.1177/135245852614…
#MentalHealth #pregnancy #MultipleSclerosis
Claudia Cantoni retweeted
Antiviral and inflammatory immune signatures in anti-CD20-treated multiple sclerosis: a cross-sectional study
link.springer.com/article/10…
Claudia Cantoni retweeted
IFNγ-induced memory in human #macrophages is sustained by the durability of #cytokine signaling itself. From Aleksandr Gorin, Alexander Hoffmann and colleagues hubs.la/Q04B0P3Z0
📘 From our #Cytokines collection: hubs.la/Q04B0P610
#Cytokines2026
Claudia Cantoni retweeted
Inducible human yolk sac myeloid progenitors model myeloid ontogeny and enable tissue-resident macrophage replacement in vivo
cell.com/developmental-cell/…
Claudia Cantoni retweeted
Embracing macrophage complexity for research and translation. cell.com/immunity/fulltext/S… @ImmunityCP
Claudia Cantoni retweeted
I want to tell you about something new today: we’re launching the @qedScience Insight Feed!🥂 I’m excited about it and want to tell you what it does and why we built it. Part of it is that I miss Science Twitter 😌
Claudia Cantoni retweeted
Unique transcriptional and epigenetic programs of IgM, IgG, and IgA antibody-secreting cells (ASC) suggest that each ASC is a distinct lineage that dictates specific functional characteristics important for humoral immunity. Learn more: ow.ly/msTU50ZUWK3.
ALT IgG-specific genes are enriched for ETS:IRF motifs and are found at cell cycle genes.
Claudia Cantoni retweeted
Elp1 is required for myeloid differentiation and brain repopulation @Nature nature.com/articles/s41586-0…
Claudia Cantoni retweeted
"rebuttal letterは、学術誌への投稿原稿を修正する際に極めて重要な文書です。ここでは、原稿の修正内容について、可能な限り好印象を与える形で伝える方法について解説します。"
nature.com/articles/s41592-0…
Claudia Cantoni retweeted
NEDA-3 at year 1 doesn't always mean stable🧵
New from @cemcat_em in @GreenJournal: 329 RMS patients starting a DMT, with serum NfL z-scores measured at baseline and at 12 months.
If the zNfL did NOT drop during year 1, the odds of disease activity in year 2 were:
🔹 3x higher overall, independent of Y1 relapses and MRI
🔹 4.5x higher in NEDA-3 patients
🔹 14x higher in treatment-naïve patients
In practice:
1️⃣ Measure sNfL at DMT start and at 12 months
2️⃣ Use z-scores, not raw values
3️⃣ No drop despite NEDA-3? Follow that patient more closely! It's a complement to the exam and MRI, not a replacement!
Proud to be part of this work 👏
🔗 doi.org/10.1212/WNL.00000000…
#MSsky #NeuroTwitter
Claudia Cantoni retweeted
Impaired control of autoimmunity increases pediatric multiple sclerosis risk in EBNA-1-seropositives and -seronegatives
pnas.org/doi/10.1073/pnas.26…
Claudia Cantoni retweeted
1/13
The human body runs on one genome—but every cell reads it differently. How?
To find out, we need to know both gene expression and chromatin accessibility in the same nucleus.
So we did, across 21 adult tissues and nearly half a million nuclei. 🧵
🔗 biorxiv.org/content/10.64898…
Claudia Cantoni retweeted
The trogocytosis plot of T cell-B cell interactions thickens!
T–B interactions yield CD3+ B cells and CD20+ T cells with pathogenic features in multiple sclerosis
pnas.org/doi/10.1073/pnas.26…
Claudia Cantoni retweeted
patterns of spinal cord injury in multiple sclerosis and other CNS autoimmune diseases. pubmed.ncbi.nlm.nih.gov/4282…
