Bernat Crosas (@CrosasLab) header
Bernat Crosas (@CrosasLab) profile picture

Bernat Crosas

@CrosasLab

Biomedical researcher at the Institute of Molecular Biology of Barcelona. Our discoveries could help people

Joined February 2013
  • Tweets366
  • Following90
  • Followers349
Well done, sister!
Mercè Crosas (@mercecrosas) profile pictureMercè Crosas@mercecrosas1 Nov 2023
Thanks @CODATANews community! I look forward to working with all of you to help improve access and use of data for better science.
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Extraordinary mechanistic dissection of proteasome activities and definition of roles of ubiquitin beyond substrate recruitment. Always @AndyMartinLab ! pubmed.ncbi.nlm.nih.gov/3656…
Image from Bernat Crosas (@CrosasLab)
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Bernat Crosas retweeted
Zuzana Hodakova (@ZHodakova) profile picture
Zuzana Hodakova@ZHodakova6 Jul 2023
Our paper describing the 3Å #cryoEM structure and chain-elongating function of UBR5, one of the largest HECT E3 ligases, is now out! at embopress.org/doi/full/10.15…
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If you're interested in degrading the "undruggable", you should pay close attention to what aptamers can do for you. #TPD pubmed.ncbi.nlm.nih.gov/3738…
Image from Bernat Crosas (@CrosasLab)
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Join us next week for #DegradoZoom on July 6th, 12pm EST: Bernat Crosas @CrosasLab IBMB: Development of proteolytic chimeras based on direct 26S proteasome targeting Muhar Matthias @matthias_muhar ETH Zürich: A chemical degron marks C-terminally modified proteins for degradation
Image from Mikołaj Słabicki (@biomiko)
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Sala plena en el retorn de @CienciaAteneu! 📊 De què parlem quan parlem de dades? Realitats, Mites i Futurs Amb Pau Garcia, de @domesticstream i @mercecrosas, del @BSC_CNS
Image from Ateneu Barcelonès (@AteneuBCN)
Image from Ateneu Barcelonès (@AteneuBCN)
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July 6th, 12pm EST Bernat Crosas @CrosasLab (IBMB) 26S proteasome PROTACs. @matthias_muhar (ETH Zürich) C-terminal chemical degron.
Image from Mikołaj Słabicki (@biomiko)
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Bernat Crosas retweeted
Ingo Hartung (@HartungIngo) profile picture
Ingo Hartung@HartungIngo18 Jun 2023
Certain MEK inhibitors induce a complex between #MEK & difficult-to-degrade #cRAF. This allows bystander degradation of recalcitrant cRAF w/ #PROTACs targeting MEK. Excellent study by the Duncan & Jin labs @FoxChaseCancer @IcahnMountSinai @biorxivpreprint biorxiv.org/content/10.1101/…
Image from Ingo Hartung (@HartungIngo)
Image from Ingo Hartung (@HartungIngo)
Image from Ingo Hartung (@HartungIngo)
Image from Ingo Hartung (@HartungIngo)
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Fascinating parallel architecture and functioning of Npl4-Ufd1-CDC48 and 19S Proteasome complexes. The same evolutionary solution put together twice in the same pathway: Ubiquitin recognition, MPN domains and ATPase engine. #TPD pubmed.ncbi.nlm.nih.gov/3673… pubmed.ncbi.nlm.nih.gov/3731…
Image from Bernat Crosas (@CrosasLab)
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Can allostery be decoded? the complexity of allosteric regulation, essential to understand cell biology and pharmacology, approached from different standpoints in two outstanding papers: elifesciences.org/articles/8… nature.com/articles/s41586-0…
Image from Bernat Crosas (@CrosasLab)
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Let's be clear: this is beauty. (historical picture of Ordesa valley, #MontePerdido presiding, at the heart of Pirineo de Huesca)
Image from Bernat Crosas (@CrosasLab)
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Spectacular tuning effect of Usp14 mediated by 3 allosteric checkpoints that make the 26S proteasome even more sophisticated. Thanks Y. Mao, D. Finley and all contributors. Retain in memory. nature.com/articles/s41586-0…
Image from Bernat Crosas (@CrosasLab)
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The 26S proteasome is this fantastic machine that nature has created to achieve homeostatic control of intracellular protein content in a timely and perfectly regulated manner. Most of the strategies used in the #TPD field rely on that. #Proteindegradation
Image from Bernat Crosas (@CrosasLab)
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If we have to have northern lights, let’s have northern lights.
Image from Bernat Crosas (@CrosasLab)
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Bernat Crosas retweeted
Joan Roig (@Nek967) profile picture
Joan Roig@Nek96728 Apr 2023
nature.com/articles/s41467-0… In where we show that dynein adaptors, like most things in life, are also regulated by phosphorylation. Featuring: BICD2 and PLK1. You heard that right: no NEKs this time (but, of course, just wait).
BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M

BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M

Nature Communications - The dynein motor complex has a variety of important functions in both dividing and non-dividing cells. Here, Gallisà et al. describe a mode of regulation of dynein...

nature.com
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Bernat Crosas retweeted
Ventura's Lab (@PPMC_UAB) profile picture
Ventura's Lab@PPMC_UAB25 Jan 2023
Today we have received the Narcís #Monturiol medal from #conseller @quimnadal @recercauniscat This wouldn’t have been possible without an amazing Team 🔝🔝 and the continued support of @UABBarcelona @IBB_UAB @Biociencies_UAB Thanks ☺️
Image from Ventura's Lab (@PPMC_UAB)
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I dont want to be part of a system that is so horrifically broken and serves to benefit the few 🧵5/5
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New steps expanding #targetedproteindegradation (#TPD) to tackle neurodegenerative diseases. #synucleinopathies pubs.acs.org/doi/10.1021/acs…
Image from Bernat Crosas (@CrosasLab)
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Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family nature.com/articles/s41467-0…
Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family

Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family

Nature Communications - A family of regulators named Catalytic Core Regulators (CCRs) oversees the function of the 20S proteasome. Here, the authors show that CCRs function through an allosteric...

nature.com
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#Ubiquitin is really amazing. Virtually unchanged during eukaryotic evolution, it has generated thousands of functionally related genes, including hundreds of ubiquitin ligases, and is involved in almost all events related to #proteostasis. #Targetedproteindegradation (#TPD)
Image from Bernat Crosas (@CrosasLab)
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