GI Oncologist, researcher

Joined August 2020
Well many of us are already using this schedule, nice to see a ph3 study that supports it.
Biweekly vs conventional trifluridine/tipiracil plus bevacizumab for refractory mCRC: The pragmatic ph 3 PRABITAS trial #ESMO26 #ESMOAmbassadors 👉ORR: 2 vs 2% 👉 mPFS: 3.9 vs 3.9 mo 👉 mOS: 10.3 vs 11.3 mo 🧐similar efficacy, less toxicity, supports biweekly schedule @myESMO @ASCO
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Daniel Sur retweeted
🔥Presidential session at ESMO 2026 🔥 CLARITY-Gastric 01: Ph 3 of sonesitatug vedotin in 2L+ CLDN18.2-positive GEC #ESMO26 #ESMOAmbassadors 👉ORR: 23 vs 13% 👉mPFS: 4.2 vs 3.8 mo 👉mOS: 10 vs 5 mo 👉No new safety signals 🧐 exciting results, new option for 2L+ CLDN18.2+ pts @myESMO @ASCO
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Daniel Sur retweeted
FOLFIRI plus ramucirumab vs paclitaxel plus ramucirumab as 2L therapy for taxane-pretreated patients with mGEA–Final results of the phase III IKFs602/AIO RAMIRIS Study #ESMO26 #ESMOAmbassadors 👉 ORR: 25 vs 23% 👉 mPFS: 5.5 vs 3.7 mo 👉 mOS: 8.7 vs 7.5 mo 🧐neg. study, but FOLFIRI + Ram appears reasonable option @myESMO @ASCO
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🚨 ESMO 2026 | TOP 10 GI CANCER TRIALS TO WATCH! From CLDN18.2 ADCs and PD-1/VEGF bispecifics to chemotherapy-free strategies, major GI oncology data are coming at #ESMO26! 🔥 My Top 10 Trials 🔴 GASTRIC / GEJ CANCER CLARITY-Gastric 01 (LBA7) | CLDN18.2 ADC vs investigator’s choice G-HOPE-001 (LBA77) | Novel CLDN18.2 ADC HERIZON-GEA-01 (LBA79) | Zanidatamab + chemotherapy ± tislelizumab GERCOR-GONO DEWI | Dostarlimab and nonoperative management in dMMR disease LOMAC (LBA81) | 4 vs 6 months of adjuvant CAPOX KC-WISE (LBA80) | Anbenitamab + chemotherapy RAMIRIS | FOLFIRI + ramucirumab vs paclitaxel + ramucirumab FORTITUDE-101/102 | FGFR2-targeted therapy and biomarker analysis 🟠 BILIARY TRACT CANCER HARMONi-GI1 (LBA8) | Ivonescimab + chemotherapy vs durvalumab + chemotherapy 🟣 ESOPHAGEAL / GEJ CANCER KEYNOTE-975 (2875O) | Pembrolizumab + definitive chemoradiotherapy ⭐ Two Presidential trials to watch closely: CLARITY-Gastric 01 and HARMONi-GI1. Which GI trial will have the greatest clinical impact? @myesmo @ESMO_open @ASCO @oncoalert #ESMO26 #GICancer #Oncology
🚨 ESMO 2026: 15 Trials That Could Change Oncology Practice! From personalized cancer vaccines and bispecific antibodies to next-generation ADCs, major results are coming. 🔥 My Top 15 to Watch: 1. INTerpath-001 | Melanoma 2. SAFFRON | EGFR+ NSCLC 3. Krascendo 1 | KRAS G12C NSCLC 4. DeLLphi-305 | ES-SCLC 5. HARMONi-GI1 | Biliary 6. VOLGA | Bladder 7. DASL-HiCaP | Prostate 8. NATALEE | Breast 9. TRIO-US B-12 TALENT | Breast 10. ENERGIZE | Bladder 11. CLARITY-Gastric 01 | Gastric 12. KEYNOTE-C93 | Endometrial 13. KEYNOTE-B49 | Breast 14. LITESPARK-011 | RCC 15. SigVie-002 | NSCLC 📊 The big question: Which trials will deliver meaningful survival benefits and redefine standards of care? Not every positive trial is practice-changing. 👨‍⚕️ Oncologists, which trial are you watching most closely? #ESMO26 #Oncology #CancerResearch @ASCO @oncoalert @myesmo @esmo_open
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🇪🇸 Excellent Spanish-led review | GEA 🧬 Beyond PD-L1 & HER2 🧪 MSI-H | EBV | TMB | Immune signatures 🎯 CLDN18.2 | FGFR2b | MET 🚀 ADCs, bispecifics & cell therapies 👏 Great work by @tfleitask , @EduardoTB94 & M. Alsina! 🔗 doi.org/10.1016/j.esmogo.202… @OncoAlert
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Dostarlimab (IV q3 wks, 9 cycles) is now @FDA ✅ for locally advanced (Stg II/III) MSI-H/dMMR rectal cancer off Ph II AZUR-1 study: - 71% got IO alone (no additional Rx) - Clinical CR for 12 mos: 47% (no progression at 26.3mos median f/u) - Surgery/Chemo free option! #gism
Replying to @AndreaCercek
@AndreaCercek 🤩announced at #ESMOGI2026 phase 2 AZUR-1 will be presented at @myESMO #ESMO2026 which was created to validate her original single center Dostarlimab data in #rectal #cancer. Looking forward to the results! #CancerResearch @GSK_US @OncoAlert
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If you are a patient with a NET or a family member or a friend or just interested NET, please check this website out.
I'm pleased to announce the launch of NENfolk.org, a patient educational site focused on neuroendocrine neoplasms (NENs) and radiotheranostics. NENfolk aims to help patients and caregivers find credible content from reputable organizations, and in the formats that fit how they want to learn. Please check it out!
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🏃‍♀️ CHALLENGE | ESMO Open Editorial 📈 5-y DFS +6.4% | 8-y OS +7.1% 🔎 38 fewer DFS events: ↘️ 42% recurrences 🧬 53% new primary cancers 💡 Exercise may prevent both colon cancer recurrence and second cancers. 🔗 doi.org/10.1016/j.esmoop.202… @OncoAlert @myESMO @GrupoTTD
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Rare cancers are a critical model for all cancers. 🔥👉🫵✴️💡🦄Adopting the orphans requires the molecular reclassification of cancer. Cancers are N-of-1 unicorns: 2012 to 2026 pubmed.ncbi.nlm.nih.gov/4161…
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I said good bye to Dr. Karan Sood at Logan Airport this afternoon as he heads back to Mumbai, India. The time he spent with us at @BrownUniversity and @BrownUnivHealth as a @WINConsortium Precision Oncology Fellow was productive and sets the stage for future work and collaboration. @Dr_R_Kurzrock @SewantiLimaye @LiaTsimberidou @VivekSubbiah @DrChoueiri @TataMemorial
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Daniel Sur retweeted
Young-onset colorectal cancer is rising, and CRC demands focus. @MDAndersonNews has created a dedicated Department of Colorectal Medical Oncology to meet that challenge. Honored to serve as its inaugural Chair and partner with new GI Med Onc chair Arvind Dasari @adasarimd #CRCSM
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Outstanding @WIN_Consortium international MTB in precision oncology this morning including challenging cases of CRC with KRAS and PIK3CA mutation, peritoneal carcinomatosis, MPNST with NF1, AXL, SUZ12, TP53 alterations among others, and recurring CRC over many years with WT KRAS, treated liver metastases, FANCA mutation now with brain metastases @Dr_R_Kurzrock @SewantiLimaye @bcarneiro7 @DrSGraff @JerryAzzoli @LiangChengMD @IAbuGheidaMD @alshamsi2000 @VivekSubbiah @DrRoyHerbst @DCarboneMD @jrgralow @billdahutmd @drKMusallam @LiaTsimberidou @RueterJens @LussierY
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🧬 New ESMO Clinical Practice Guidelines | Gastric & oesophageal cancer 📚 Full patient journey: diagnosis → staging → treatment → follow-up 🧪 HER2 | MSI | CLDN18.2 | PD-L1 🎯 Recommendations tailored by stage, prior therapy & molecular profile 🔗 doi.org/10.1016/j.annonc.202… @OncoAlert
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This is the future of oncology. Algorithm/AI-driven biomarker matching to unravel complexity
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🤝An international collaboration with @aparna1024 and our CRC team @incliva_iis @GVAsanitat
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🏃‍♀️ Exercise oncology | Nat Rev Clin Oncol 🔻 ↓ risk of several cancers 📉 ↓ cancer-specific/all-cause mortality after diagnosis ✅ CHALLENGE: ↑ DFS/OS in colon cancer ⚠️ No proven improvement in tumor response 🎯 Toward precision exercise oncology. 🔗 doi.org/10.1038/s41571-026-0… @OncoAlert
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🚨⭐️HOT OFF THE PRESS👉Pleased to share our new paper, led by the amazing @JulianaRBeal @niamhjcoleman @JiaJennyLiu 👉Precision before incision: neoadjuvant tumor-agnostic therapies.” 👉Nine tumor-agnostic drugs now have a case for earlier use, before resistance sets in and with organ preservation in mind. 👉A PD-1 blockade hit a 100% complete response in MMR-deficient rectal cancer. 🧬 @JasonSicklick @OncoAlert @oncodaily cell.com/trends/cancer/abstr… #PrecisionOncology
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Dr. Keith Flaherty, Director Exp Therapeutics, MGH, AACR President delivers Keynote entitled “Extending the Boundaries of Bedside-to-Bench Translational Research to Realize Rational Combination Therapies” at the 2026 WIN Symposium at the Rhode Island Convention Center in Providence, Rhode Island, USA. Keith T. Flaherty, MD, FAACR is a Member, Scientific Advisory Board, WIN Consortium. He is the Richard Saltonstall Chair in Oncology, Massachusetts General Hospital, Professor of Medicine at Harvard Medical School, USA and President of the American Association for Cancer Research (AACR). As described in more than 350 peer reviewed primary research reports he has authored or co-authored, Dr. Flaherty and colleagues made several seminal observations that have defined the treatment of melanoma when they established the efficacy of BRAF, MEK and combined BRAF/MEK inhibition in patients with metastatic melanoma in a series of New England Journal of Medicine articles for which Dr. Flaherty was the first or senior author. He was the principal investigator of the NCI MATCH trial, the first NCI-sponsored trial assigning patients to targeted therapy independent of tumor type on the basis of DNA sequencing detection of oncogenes. Dr. Flaherty joined the NCI Board of Scientific Advisors in 2018 (chair 2021-23), the AACR Board of Directors in 2019, and was elected President of AACR in 2025. Dr. Flaherty co-founded Loxo Oncology in 2013 and Scorpion Therapeutics in 2020, serving on the board of directors through the acquisitions of both by Eli Lilly in 2019 and 2025. He co-founded X4 Pharmaceuticals, privately held Strata Oncology (2015), Apricity Oncology (2017), Gyges Oncology (2020), Khora Therapeutics (2024), and Monimoi Therapeutics (2025). Dr. Flaherty's presentation was ~24 minutes long followed by ~18 minutes of questions by global leaders in precision oncology, AI, clinical oncology, and patient advocacy. youtube.com/watch?v=R83QStfI… @WIN_Consortium @Dr_R_Kurzrock @AACR @AACRPres @AmericanCancer @ASCO @SewantiLimaye @LiaTsimberidou @LussierY @LiangChengMD @DrRoyHerbst @VivekSubbiah @CancerConnector @JiaJennyLiu @TaberneroJosep @jrgralow @curijoey @oncodaily @Oncotarget @theNCI @NCIDirector @AACI_Cancer
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Superb WIN fellows. Pleased to lead the WIN international fellowship with Wafik EL Deiry. Training the best and brightest from three continents!
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