Molecular virologist, antivirals, innate immunity, coronavirus, ebolavirus, RSV, HIV, Flavivirus. CNRS,
Marseille, France
Joined January 2019
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Some information published in Science regarding the possibility of a laboratory-acquired infection with the plague bacterium in a technician working in a BSL-3 laboratory in the city of Irkutsk.
science.org/content/article/…
It is important to note that strains of Yersinia pestis resistant to several antibiotics have already been described in the scientific literature.
pmc.ncbi.nlm.nih.gov/article…
Decroly Etienne retweeted
Version Hantavirus infographic #13 [13 cases as well].
A new @news.abc.net.au story hints that quarantine (at least in Aus) has been based on the disembarkation date (completed May 11). I've added that in as an orange-shaded box.
Anything unclear?
Decroly Etienne retweeted
May 24 Ebola Update
First case ~ March 27
Outbreak undetected ~ 7 weeks
1,010 cases
Doubling time ~4.4 days
R0 ~ 4.8
Re ~ 2.0
June 30 est:
13K cases
3K deaths
Concerning the human/human transmission: is it limited to direct and close contact, or is there also transmission through microdroplets and aerosols? this is addressed in this paper, which discusses the precautionary measures that should be taken. bmj.com/content/393/bmj.s919
Sequences of the Hantavirus isolated in Switzerland from a symptomatic patient are now available. virological.org/t/complete-s…. The analysis indicates that the closest relatives are Argentine viruses.
It is not certain that (1) the rapid repatriation by plane of passengers from the ship to their countries of origin, and (2) heterogeneous containment measures depending on countries, represent the best strategy to control this emergence.
A sixth article documents the human-to-human transmission of Andes virus and presents phylogenetic analyses of Gn/Gc sequences: "Hantavirus Pulmonary Syndrome Outbreak in Argentina: Molecular Evidence for Person-to-Person Transmission of Andes Virus."
The fifth article (as well as the fourth) discusses neutralization by antibodies capable of recognizing the Gc/Gn protein, which is responsible for cellular receptor recognition and viral entry into cells. The good news is that several neutralizing antibodies exist.
