A nonprofit startup building an open atlas of surface protein abundance & internalization • We're hiring https://teapaw.org/t.co/4WQeMCGeIW
Cambridge
Joined March 2026
- Tweets38
- Following56
- Followers519
- Likes60
Pinned Tweet
Our first paper is out! An open, evidence-backed atlas of the accessible human surfaceome. Explore every protein's surface verdict and the literature quotes behind it 👇🎯
Five major databases of human surface proteins agree on only 188 of them. So we had Claude read the literature instead. Today @deliverome is releasing an open atlas of the accessible human surfaceome, with claims traced directly to quotes from their source 🎯
This week, we celebrated the arrival of our proteomics scientist, @a_metousis, and our Astral Zoom with the winner of our first bracket (desserts): carrot cake! 🍰
What should compete in the next Deliverome bracket? Swiss rounds next time?
7
310
Our Orbitrap Astral Zoom gets installed this Friday 🎉 Now we're looking for more team members to put it to work!
First up: a founding Senior Scientist in chemoproteomics/surfaceomics to map surface abundance and internalization, fully open-source 👇
ALT Diagram: surface proteins labeled with cleavable biotin, internalized at 37°C, surface biotin stripped with a cell-impermeable reducing agent, and internalized proteins captured by streptavidin pull-down for MS quantitation.
The Deliverome Project retweeted
Interest is growing in starting blind challenges to galvanize communities to solve important commons problems and assess frontier AI. Through our experience with OpenADMET, we've learned lessons, built infrastructure, and hope to help other communities do the same. We're building playbooks & infrastructure for others who want to start their own challenges. We will continue to share more over time. Thank you to @beckypferdehirt and Radial / @AsteraInstitute for the support (and push) to make this happen. openadmet.ghost.io/open-sour…
A couple of weeks ago, Austin Tedman came to speak to Deliverome about his recent paper — and we're releasing the journal club publicly!
This is a key study for our work at Deliverome, where we are working to synthesize a surfaceome-wide library to study both surface expression and internalization and trafficking.
1
1
46
Watch the talk: youtube.com/watch?v=OWm12Ij_…
Read the paper: nature.com/articles/s41467-0…
Addgene libraries: addgene.org/pooled-library/s…
Plasmid maps: data.mendeley.com/datasets/3…
The Deliverome Project retweeted
What would it take for AI to compress decades of scientific progress into years, and make that progress open, verifiable, and widely shared? In just a few weeks, some of the best minds working on this are joining us for a 2-day workshop in San Francisco.
Speakers include:
• @soniaarrison, @100Plus Capital
• @tomoxl, @synchroninc
• @MartinBJensen, @GordianBio
• @dileeplearning, @AsteraInstitute
• @MollyminHe, @ElemBio
• @nabihasaklayen, @CellinoBio
• @mikhailshapiro, @Caltech
• @elidourado, @AsteraInstitute
• Sean Escola, @protocollabs
• @Alexteng, @fiftyyears
• @draparente, @CivilizationVC
• @beccajcarlson, @deliverome
• @Ben_Reinhardt, @Spec__Tech
• @vivnat, @GoogleDeepMind
This workshop is part of our AI Node program in the Bay Area. Participants can stay and sprint at our SF Node for a few weeks afterward to keep building in community.
If you’re researching or building at the intersection of AI and scientific discovery, apply to attend. Link in first reply.
The Deliverome Project retweeted
Congratulations to @beccajcarlson and @BobbyHollings for the @Deliverome project. I’m delighted that a donor that @RenPhilanthropy works with is providing $5M, building on initial support from @AsteraInstitute. The Deliverome project is hiring and looking for additional partners and funders. What other datasets we should create?
1/ We’re deeply grateful to @RenPhilanthropy for an additional $5M grant supporting the Deliverome Project’s nonprofit mission. 🧵
The Deliverome Project retweeted
@tkalil2050 recently spoke to @beccajcarlson and @BobbyHollings, co-founders of the @deliverome Project, who have launched an FRO to accelerate progress in developing targeted therapies.
Read Tom’s Q&A with Becca and Bobby about why they chose the FRO model, and what they’re working on at the Deliverome Project: renaissancephilanthropy.subs…
2/2
1/ We’re deeply grateful to @RenPhilanthropy for an additional $5M grant supporting the Deliverome Project’s nonprofit mission. 🧵
We’re seeking partners to fund 1) collection of healthy human tissues from 50+ donors for profiling and 2) synthesis of a DNA library of surface proteins that we will make available to all on @Addgene and 3) additional projects. We’d love to hear from you! [email protected].
The Deliverome Project retweeted
Just over a month ago the @Deliverome lab was almost empty. Today, we started experiments with our first bottle of media 🧫
Our first scientists join soon, and we're still looking for more to build the first open surface protein atlas.
Come experiment with us!