@DenholmLab
Joined August 2017
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Our paper on the evolution of Cryptonephridial/rectal complexes in scarab beetles is just out in Arthropod Structure & Development sciencedirect.com/science/ar…
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PhD position in @DenholmLab ' Exploring form & function in one of nature’s most powerful water-conservation systems' working on insect renal system development, physiology and evolution. findaphd.com/phds/project/ea… apply by 17th January 2025. Please repost

EASTBIO Exploring form & function in one of nature’s most powerful water-conservation systems at...

PhD Project - EASTBIO Exploring form & function in one of nature’s most powerful water-conservation systems at University of Edinburgh, listed on FindAPhD.com

findaphd.com
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journals.biologists.com/dev/… Excited to have this published in Development - the first molecular insights into development / cell type specification in the beetle cryptonephridial complex

Something old, something new: the origins of an unusual renal cell underpinning a beetle water-co...

Summary: An unusual renal cell type underpinning the water-conservation mechanism of a major beetle lineage is derived from an ancestrally present cell type and specified by a conserved transcription...

journals.biologists.com
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The latest on the beetle cryptonephridial complex from our collaboration between @DenholmLab and @HalbergLab doi.org/10.1101/2024.03.01.5…
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Here is our first foray into the digestive/renal systems of scarab beetles biorxiv.org/content/10.1101/…

Evidence for the independent evolution of a rectal complex within the beetle superfamily Scarabae...

Rectal or cryptonephridial complexes have evolved repeatedly in arthropods, including in beetles where they occur in ∼190,000 species of Cucujiformia and Bostrichoidea, and Lepidoptera where they...

biorxiv.org
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Denholm Lab retweeted
HalbergLab@HalbergLab3 Oct 2022
How do some insects survive without access to water? By drinking from the air with their anus of course! Also, new online resource for #Tribolium enthusiasts, BeetleAtlas.org. New preprint from the lab: biorxiv.org/content/10.1101/…. Great colab with @DenholmLab+many not on T
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New Research: Piezo buffers mechanical stress via modulation of intracellular Ca2+ handling in the Drosophila heart frontiersin.org/articles/10.… #Physiology
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Our paper is out! - How does proximo-distal patterning occur in the epithelial Malpighian/renal tubules? Cells are patterned early by a mechanism involving Wingless/Wnt, and expand by cell proliferation to generate a distal domain frontiersin.org/articles/10.…
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Paradise lost. 7 years ago! Collecting mulberry leaves with @AdiSaxena4 to feed our Bombyx caterpillars. Milton's mulberry tree #ChristCollege #Cambridge #paradiselost
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Belly dancer. Movie of a fly crop imaged by @EdinburghUni undergrads having fun in the lab #drosophila #drosophilagut #gut #fridayafternoonexperiments
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PhD position - Emergence of functional polarity in a tubular epithelium thenode.biologists.com/phd-p… via @the_Node
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anyone interested in a PhD in tubes? findaphd.com/phds/project/ea…
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5th Scottish Fly Meeting: Friday 6th December 2019 at Edinburgh University. Please join us, it's free: eventbrite.co.uk/e/5th-scott…
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Fly people - 5th Scottish Fly Meeting will be on Friday 6th December 2019 in Edinburgh! Please save the date and spread the word. More details to follow
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Fab new manuscript on rodent limbs from @AdiSaxena4 and @UCSDCooperLab Interspecies transcriptome analyses identify genes that control the development and evolution of limb skeletal proportion biorxiv.org/content/10.1101/…

Interspecies transcriptome analyses identify genes that control the development and evolution of...

Despite the great diversity of vertebrate limb proportion and our deep understanding of the genetic mechanisms that drive skeletal elongation, little is known about how individual bones reach...

biorxiv.org
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Excited to share our publication on Wg gradient signaling in Drosophila wing discs. Online now @Dev_journal dev.biologists.org/content/1… Also check out the research highlight. Thanks and congratulations to all collaborators. Very proud of Swapnil's work.
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Check out their full Open Access paper 'Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing' here: dev.biologists.org/content/1…
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Denholm Lab retweeted
KotaMizumoto@Ko_Mizumo26 Jul 2019
Here we go. Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans biorxiv.org/content/10.1101/…

Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans

During development, the nervous system undergoes refinement process by which neurons initially extend an excess number of neurites, the majority of which will be eliminated by the mechanism called...

biorxiv.org
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Today, I have got a review report from @PLOSONE after a more than 3 months of waiting ... reviewer #3 wrote: "Overall my assessment is very negative and I would discourage the publication of this work (even after substantial revisions) in any scientific journal" 🤣 #NeverGiveUp
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Denholm Lab retweeted
nature
@Nature5 Jul 2019
Cassandra Extavour has transformed our understanding of animal development, in some cases disproving widely accepted hypotheses about development and evolution. go.nature.com/2FRDmFF
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