@DevBio_UofT

Collaborative Specialization in Developmental Biology at the University of Toronto

 Toronto, Ontario
devbio.utoronto.ca/
Joined April 2018
  • Tweets282
  • Following195
  • Followers254
3Media
Congrats to the @MRSantosLab! m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency pubmed.ncbi.nlm.nih.gov/3769…

m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency - PubMed

Embryos across metazoan lineages can enter reversible states of developmental pausing, or diapause, in response to adverse environmental conditions. The molecular mechanisms that underlie this...

pubmed.ncbi.nlm.nih.gov
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Congrats to the @XiHuang18 lab! A designer peptide against the EAG2-Kvβ2 potassium channel targets the interaction of cancer cells and neurons to t… pubmed.ncbi.nlm.nih.gov/3769…

A designer peptide against the EAG2-Kvβ2 potassium channel targets the interaction of cancer cells...

Glioblastoma (GBM) is an incurable brain cancer that lacks effective therapies. Here we show that EAG2 and Kvβ2, which are predominantly expressed by GBM cells at the tumor-brain interface, physica...

pubmed.ncbi.nlm.nih.gov
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Congrats to the @SheckyFeinblatt lab! aristaless-like homeobox-3 is wound-induced in muscle and stem cells and is required for planarian head regeneration pubmed.ncbi.nlm.nih.gov/3768…

aristaless-like homeobox-3 is wound induced and promotes a low-Wnt environment required for...

The planarian Schmidtea mediterranea is a well-established model of adult regeneration, which is dependent on a large population of adult stem cells called neoblasts. Upon amputation, planarians...

pubmed.ncbi.nlm.nih.gov
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Busy day for CSDB labs - congrats to the @Reinke_Science lab! Genomic and phenotypic evolution of nematode-infecting microsporidia pubmed.ncbi.nlm.nih.gov/3747…

Genomic and phenotypic evolution of nematode-infecting microsporidia - PubMed

Microsporidia are a large phylum of intracellular parasites that can infect most types of animals. Species in the Nematocida genus can infect nematodes including Caenorhabditis elegans, which has...

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Congrats to the Rossant lab! Influence of FGF4 and BMP4 on FGFR2 dynamics during the segregation of epiblast and primitive endoderm cells in the… pubmed.ncbi.nlm.nih.gov/3747…

Influence of FGF4 and BMP4 on FGFR2 dynamics during the segregation of epiblast and primitive...

Specification of the epiblast (EPI) and primitive endoderm (PE) in the mouse embryo involves fibroblast growth factor (FGF) signaling through the RAS/MAP kinase pathway. FGFR1 and FGFR2 are thought...

pubmed.ncbi.nlm.nih.gov
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Congrats to the @PaulDelgadoOlgu lab! G9a inactivation in progenitor cells with an Isl1-Cre with reduced recombinase activity models aspects of Dandy-Wal… pubmed.ncbi.nlm.nih.gov/3747…

G9a inactivation in progenitor cells with Isl1-Cre with reduced recombinase activity models aspects...

G9a, also known as EHMT2, is essential for embryogenesis and has specific functions in multiple developmental processes. G9a inactivation affects development of the nervous system, which is formed...

pubmed.ncbi.nlm.nih.gov
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Congratulations to the @cirunalab! COL11A2 as a candidate gene for vertebral malformations and congenital scoliosis pubmed.ncbi.nlm.nih.gov/3746…

COL11A2 as a candidate gene for vertebral malformations and congenital scoliosis - PubMed

Human vertebral malformations (VMs) have an estimated incidence of 1/2000 and are associated with significant health problems including congenital scoliosis (CS) and recurrent organ system malforma...

pubmed.ncbi.nlm.nih.gov
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Congrats to the @RFG_Lab! cell.com/developmental-cell/…

Myosin waves and a mechanical asymmetry guide the oscillatory migration of Drosophila cardiac...

Embryonic heart development begins with the directional migration of cardiac progenitors to form a tube. Balaghi et al. report that, in Drosophila, cardiac progenitors move directionally, but not...

cell.com
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Congrats to the @DanielSchramek lab! In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer pubmed.ncbi.nlm.nih.gov/3725…

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung...

How the genetic landscape governs a tumor's response to immunotherapy remains poorly understood. To assess the immune-modulatory capabilities of 573 genes associated with altered cytotoxicity in...

pubmed.ncbi.nlm.nih.gov
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Congrats to the @RFG_Lab! Rap1 coordinates cell-cell adhesion and cytoskeletal reorganization to drive collective cell migration in vivo pubmed.ncbi.nlm.nih.gov/3724…

Rap1 coordinates cell-cell adhesion and cytoskeletal reorganization to drive collective cell...

Collective cell movements contribute to tissue development and repair and spread metastatic disease. In epithelia, cohesive cell movements require reorganization of adherens junctions and the...

pubmed.ncbi.nlm.nih.gov
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Congrats to the Zuniga-Pflucker lab! Recent Thymic Emigrants Require RBPJ-Dependent Notch Signaling to Transition into Functionally Mature Naive T Cells pubmed.ncbi.nlm.nih.gov/3715…

Recent Thymic Emigrants Require RBPJ-Dependent Notch Signaling to Transition into Functionally...

Recent thymic emigrant (RTE) cells are nascent T cells that continue their post-thymic maturation in the periphery and dominate T cell immune responses in early life and in adults having undergone...

pubmed.ncbi.nlm.nih.gov
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Congrats to the Ellis lab! Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models pubmed.ncbi.nlm.nih.gov/3701…

Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models -...

Transcriptional changes in Rett syndrome (RTT) are assumed to directly correlate with steady-state mRNA levels, but limited evidence in mice suggests that changes in transcription can be compensated...

pubmed.ncbi.nlm.nih.gov
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Congrats to the @PeterJRoy lab! Nemacol is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter with anthelmintic potential pubmed.ncbi.nlm.nih.gov/3700…

Nemacol is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter with...

Nematode parasites of humans and livestock pose a significant burden to human health, economic development, and food security. Anthelmintic drug resistance is widespread among parasites of livestock...

pubmed.ncbi.nlm.nih.gov
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Congrats to the @marc_meneghini lab! Diverse yeast antiviral systems prevent lethal pathogenesis caused by the L-A mycovirus pubmed.ncbi.nlm.nih.gov/3688…

Diverse yeast antiviral systems prevent lethal pathogenesis caused by the L-A mycovirus - PubMed

Recent studies show that antiviral systems are remarkably conserved from bacteria to mammals, demonstrating that unique insights into these systems can be gained by studying microbial organisms....

pubmed.ncbi.nlm.nih.gov
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Congrats to the @Reinke_Science lab! High-throughput phenotyping of infection by diverse microsporidia species reveals a wild C. elegans strain with opp… pubmed.ncbi.nlm.nih.gov/3689…

High-throughput phenotyping of infection by diverse microsporidia species reveals a wild C. elegans...

Animals are under constant selective pressure from a myriad of diverse pathogens. Microsporidia are ubiquitous animal parasites, but the influence they exert on shaping animal genomes is mostly...

pubmed.ncbi.nlm.nih.gov
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Congrats to @jonathanpalozzi and the @hurd_lab! The role of programmed mitophagy in germline mitochondrial DNA quality control pubmed.ncbi.nlm.nih.gov/3680…

The role of programmed mitophagy in germline mitochondrial DNA quality control - PubMed

Mitochondrial DNA (mtDNA) is prone to the accumulation of mutations. To prevent harmful mtDNA mutations from being passed on to the next generation, the female germline, through which mtDNA is...

pubmed.ncbi.nlm.nih.gov
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Congrats to the @JulieBrill5 lab! Eukaryotic translation initiation factor eIF4E-5 is required for spermiogenesis in Drosophila melanogaster pubmed.ncbi.nlm.nih.gov/3669…

Eukaryotic translation initiation factor eIF4E-5 is required for spermiogenesis in Drosophila...

Drosophila sperm development is characterized by extensive post-transcriptional regulation whereby thousands of transcripts are preserved for translation during later stages. A key step in translat...

pubmed.ncbi.nlm.nih.gov
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Congrats to the @farmgirlphd lab! A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions pubmed.ncbi.nlm.nih.gov/3679…

A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory...

Argonaute (AGO) proteins associate with small RNAs to direct their effector function on complementary transcripts. The nematode Caenorhabditis elegans contains an expanded family of 19 functional AGO...

pubmed.ncbi.nlm.nih.gov
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Congrats to the @GilbertLab! The mini-IDLE 3D biomimetic culture assay enables interrogation of mechanisms governing muscle stem cell quiescence… pubmed.ncbi.nlm.nih.gov/3653…

The mini-IDLE 3D biomimetic culture assay enables interrogation of mechanisms governing muscle stem...

Adult skeletal muscle harbours a population of muscle stem cells (MuSCs) that are required for repair after tissue injury. In youth, MuSCs return to a reversible state of cell-cycle arrest termed...

pubmed.ncbi.nlm.nih.gov
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Developmental Biology Program At U Of Toronto retweeted
Medicine by Design@MbD_CCRM7 Feb 2023
Looking forward to our next Global Speaker Series with Jeff Biernaskie from @ucalgaryvetmed. In partnership with @McEwenInstitute. This event is also sponsored by @DevBio_UofT. Register to attend in-person or virtually: mbd.utoronto.ca/event/global….
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