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DevBio Lab101

@DevLab101

Cell & Developmental Biology Lab at @UntTuc and @INSIBIO studying #neuralcrest #embryogenesis #xenopus, and #oleaginousyeast #yeast #biotech. PI: @M_Aybar

 Tucumán, Argentina
Joined July 2020
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🐟In zebrafish, the functions attributed to TCOF1 and NOLC1 are carried out by a single gene, nolc1. 🌳 Our phylogenetic tree shows that TCOF1 orthologues are mostly restricted to tetrapods.
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Waste to Biodiesel! ⛽ We share our paper, that unlocks sustainable #biodiesel from waste! We show how to use #waste from sugar & biodiesel industries to cultivate #Rhodotorula glutinis R4 yeast, which produces high-quality oils for biodiesel. t.ly/EwRWU
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4/5 Many #teratogens and #syndromes are considered #FASD #digeorgesyndrome #22q11 #CHARGEsyndrome #ADHD #Zika #TetralogyofFallot #CHD #WaardenburgSyndrome #Waardenburg #TietzSyndrome #Albinism #BranchioOculoFacialSyndrome (list continues)
Table 2 describes known effects of #teratogens on #neuralcrest

ALT Table 2 describes known effects of #teratogens on #neuralcrest

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3/5 The way external factors (#teratogens) specifically affect the #neuralcrest development and lead to environmental #neurocristopathies and #birthdefects resulting from alterations in molecular and developmental processes is discussed
The relationship of #teratogens and their action on #neuralcrest development processes

ALT The relationship of #teratogens and their action on #neuralcrest development processes

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2/5 We first covered #devbio aspects of #neuralcrest formation and a complete and actualized list of derivatives is included
Table 1 (an extract in this snapshot) shows the cell-types derived from #neuralcrest acording to their axial developmental origin #devbio #embryo

ALT Table 1 (an extract in this snapshot) shows the cell-types derived from #neuralcrest acording to their axial developmental origin #devbio #embryo

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4/5 Oil produced by R4 is similar to vegetable oils, and its fatty acid (FA) profile contains mainly C16 and C18 FA. The most abundant FA were oleic (C18:1), palmitic (C16:0) and linoleic #Rhodotorula #lipids #oleaginousyeast #biotech #biosynthesis
Thin-Layer Chromatography analysis of lipids present in oil extracts of oleaginous yeasts and olive oil (TAG, triacylglycerides; DAGs, diacylglycerides; MAGs, monoacylglycerides; FFA, free-fatty acids)

ALT Thin-Layer Chromatography analysis of lipids present in oil extracts of oleaginous yeasts and olive oil (TAG, triacylglycerides; DAGs, diacylglycerides; MAGs, monoacylglycerides; FFA, free-fatty acids)

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3/5 The growth parameters of R4 and 8 #oleaginousyeast #yeasts showed R4 accumulates 6.8 g/liter of intracellular #lipids, that represents 47.24% (weight/weight) of the dry #biomass #Rhodotorula
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2/5 Under nitrogen limiting conditions and excess of carbon source in the culture, R4 #yeast showed a remarkable #lipids production, which was comparable to the best #oleaginousyeast
#oleaginousyeast Rhodotorula glutinis R4 growth (△; log OD 600 nm), residual glucose (○; g/L), YAN (Yeast Assimilable Nitrogen; □; mg/N/L), lipids production (g/L; red bars) after 120 and 144 h

ALT #oleaginousyeast Rhodotorula glutinis R4 growth (△; log OD 600 nm), residual glucose (○; g/L), YAN (Yeast Assimilable Nitrogen; □; mg/N/L), lipids production (g/L; red bars) after 120 and 144 h

Micrograph shows florescent lipid droplets (left) of the #oleaginousyeast R. glutinis R4

ALT Micrograph shows florescent lipid droplets (left) of the #oleaginousyeast R. glutinis R4

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4/5 our work integrates experimental and genomic data and Studies in #DiseaseModel like #mice #chicken #xenopus #zebrafish, and #neuroscience #neurology #cranialnerve contributions of researchers like frontiersin.org/articles/10.…
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3/5 The role of BMP, Hippo, Notch, Shh, RTK (receptor tyr kynase) cell signaling, and families of relevant transcription factors are discussed and integrated in the context of neural crest-derived #cranialnerves and #ganglia formation, and the associated #neurogenesis.
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2/5 #neuralcrest (NC) contribute to #cranialnerves I, III, V, VII, VIII, IX, X, and XI (fig2, green). NC-derived Schwann cells myelinate III–XII. The complex and multistep process of NC formation is reviewed, considering tissue interactions and inductive cell signals
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Excelent chronicle about the Courses of Developmental Biology in LatinAmerican, by R. Mayor (@mayor_lab). Great pictures! #PhDLife #DevBio #LatinAmerica #Embryology Find out more: ijdb.ehu.es/web/paper/200049… – at Santiago, Chile
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