@Dpla_

Professor @hhu_de Mitochondrial Biology 🧬 | Institute of Biochemistry and Molecular Biology I | mitochondria, mtDNA and mitophagy 🇪🇸🇩🇪 https://xitter.cf/t.co/998Ng2Kg2x

 Düsseldorf, Alemania
Joined January 2012
  • Tweets1.3K
  • Following752
  • Followers2.7K
126Media
mtDNA alterations in muscle progenitors determine myoblast differentiation and disrupt skeletal muscle architecture: Cell Reports cell.com/cell-reports/fullte…

mtDNA alterations in muscle progenitors determine myoblast differentiation and disrupt skeletal...

The role of mtDNA integrity in muscle progenitor function remains poorly understood. Sen et al. show that mtDNA alterations in myoblasts impair myogenic differentiation and reshape the mitochondrial...

cell.com
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Juan Cruz Landoni@jclandoniOct 25
We wrote a short forum piece with @SulianaManley discussing the dynamic puzzle of mitochondrial DNA #mtDNA regulation across scales. Thank you @CellPressNews Trends in Genetics for the invitation! Open-access article: authors.elsevier.com/sd/arti…
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After so many years, I have finally a website plamartinlab.org
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Artal-Sanz lab@artal_sanzOct 15
Check our latest publication! USP-48 enables insulin-mediated longevity and modulates the mitochondrial stress response: Cell Reports cell.com/cell-reports/fullte…

USP-48 enables insulin-mediated longevity and modulates the mitochondrial stress response

Gordillo-García et al. perform a genome-wide double-RNAi screen and identify the deubiquitinase USP-48 as a regulator of the mitochondrial unfolded protein response. USP-48 cooperates with DVE-1,...

cell.com
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KondadiLab@KondadiLabOct 11
Humbled and ecstatic to organize the India | EMBO Lecture Course on mitochondrial biology in Hyderabad, 26–30 July 2027! A fantastic lineup of eminent scientists from across the globe! Looking forward to exciting science and collaborations! meetings.embo.org/event/27-m…

Mitochondrial form, function and signalling across biological scales

The non-canonical functions of mitochondria have expanded rapidly over the past two decades, and now encompass nucleotide metabolism, immune and ion signalling, inflammation, lipid and protein synthe…

meetings.embo.org
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Cell Biology J-Club@cell_clubOct 8
Golgi-derived vesicles containing PI(3,4)P2 drive mitochondrial fusion | Science science.org/doi/10.1126/scie…

Golgi-derived vesicles containing PI(3,4)P2 drive mitochondrial fusion

Mitochondria are dynamic organelles that remodel their shape to regulate cell fate. Mitochondrial division involves interactions with the endoplasmic reticulum (ER), lysosomes, and trans-Golgi...

science.org
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Tiago Branco Fonseca@FonsecaBrancoSep 30
Uuuu let’s go Nuno!! 🤩
MITOtalks@MitOtalksSep 28
What if mitochondria have a buddy to supply them with the right substrates at the right time? Tune in this thursday, and our speaker @nunoraimundo will tell you how mitochondria-lysosome crosstalk can be a tool when metabolism needs to be rewired. See you there?
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Nuno Raimundo@nunoraimundoSep 28
Sometimes the MITOtalks go home for a brief visit...
MITOtalks@MitOtalksSep 28
What if mitochondria have a buddy to supply them with the right substrates at the right time? Tune in this thursday, and our speaker @nunoraimundo will tell you how mitochondria-lysosome crosstalk can be a tool when metabolism needs to be rewired. See you there?
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Cell Biology J-Club@cell_clubSep 17
Version of record. Lipids regulate export of lysosomal enzymes from the endoplasmic reticulum | PNAS pnas.org/doi/10.1073/pnas.26…

Lipids regulate export of lysosomal enzymes from the endoplasmic reticulum | PNAS

Lysosomal enzymes are synthesized in the Endoplasmic Reticulum (ER) and transported to lysosomes to execute their functions. Deficiencies in lysoso...

pnas.org
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Confocal NL@confocal_nlSep 16
Great to be at @EMBO #EMBOCLEM! 🔬 Today, attendees used our AION confocal microscope for a CLEM experiment, enabling rapid four-color imaging and direct correlation of fluorescence data with EM images. Great to see AION in action! #CLEM #Microscopy
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Cell Biology J-Club@cell_clubSep 16
Cholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria | Nature Communications nature.com/articles/s41467-0…

Cholesterol maintains the degradative capacity of lysosomes during clearance and recycling of...

Nature Communications - Damaged mitochondria are cleared by lysosomes. Here, authors show that ER-to-lysosome cholesterol transport preserves lysosomal degradative function during mitophagy,...

nature.com
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This story started in Cologne with my first big grant together with Rudi Wiesner and finished in my own lab in Düsseldorf. Here we investigated what happens to muscle myoblasts when mtDNA replication is impaired.
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This story started in Cologne with my first big grant together with Rudi Wiesner and finished in my own lab in Düsseldorf. Here we investigated what happens to muscle myoblasts when mtDNA replication is impaired. Check it out
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David Pla-Martín retweeted
Journal of Cell Biology@JCellBiolSep 9
PISD acts as a switch between #lipophagy and fatty acid transfer to #mitochondria. From Hanbing Xue, Xingwen Hu, Zhenni Yang, Yan G. Zhao and colleagues: hubs.la/Q04w6BY10 📕 From our #Lipid and #Membrane collection: hubs.la/Q04w6v3r0
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Artal-Sanz lab@artal_sanzSep 3
we are hiring! a 4 years PhD position to study Mitochondrial Signalling in Ageing in Seville
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Alexis A. Jourdain@jourdainlabAug 20
New paper from the lab! 🎉 In this new story, we venture into the fascinating world of macrophage immunometabolism. Beautiful work led by @joanblanco14 the lab’s very first PhD student & macrophage expert! Have a look at Joan’s post for more! 👇
Joan Blanco-Fernandez@joanblanco14Aug 19
We all adapt to changes in our environment and stress, and so do the #mitochondria in our #macrophages! 🪇I am happy to share that my main PhD project at the @jourdainlab at @DIB_UNIL @unil is out in @ScienceAdvances 🎉 🔗 science.org/doi/10.1126/scia… Check below for more! 🧵 1/6
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How pleasant to read “I am pleased to let you know that your manuscript has now been “accepted in principle” as a Research Article  at…” on a Friday evening before vacation
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Journal of Cell Biology@JCellBiolJun 26
Jenkins, Botelho et al. show that the PIKfyve #lipid kinase extends its sphere of influence to modulate the architecture & dynamics of the ER by balancing phosphoinositide species at their inter-organellar sites. hubs.la/Q04mQ5Gw0 #Organelles #Membrane #ER_literature
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Mizushima Lab (UTokyo)@MizLabUTJun 26
Our new paper is out in @ScienceMagazine! We developed mice with reversible control of autophagy, and showed that restoring this pathway after its suppression reverses neuronal abnormalities and brain dysfunction, demonstrating the resilience of neurons. science.org/doi/10.1126/scie…

Reversible suppression of autophagy in a mouse model reveals neuronal resilience

Impairments in intracellular quality-control mechanisms, including autophagy, affect neuronal integrity and function. Despite numerous studies aimed at slowing neuronal deterioration, it remains...

science.org
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