Academic @UniofExeter. Computational psychiatry, medicine, brains, guitars, code, coffee, maths, cycling, beer, AI. Tired dad. Alum @cubriccardiff & @mrccbu
Exeter, England
Joined September 2014
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Alex 🇺🇦 retweeted
🧠 Our new paper Restoring Synaptic Balance in Schizophrenia: Insights From a Thalamo-Cortical Conductance-Based Model is now published in Schizophrenia Bulletin.
🚀 Join us at SiC25 – First Int’l Superintelligence Conf.
🗓 17–18 Sept 2025 | Exeter, UK
🎙 Keynotes: Bertie Müller, Ana Beduschi, Stuart Armstrong
Explore the future of #AI & #AGI 🌍
🔗 Register: lnkd.in/ezKJ3fTB
#Superintelligence
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Alex 🇺🇦 retweeted
chance to do a phd with me on GABA alcohol alternatives un humans? findaphd.com/phds/project/fr…
Alex 🇺🇦 retweeted
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science
go.nature.com/44hKo29
Testing an Active Inference agent in a 3D drone navigation task — it infers its own position and velocity from noisy observations, and selects actions by rolling out belief-based trajectories and minimizing expected free energy.
#ActiveInference #BayesianLearning #AI #AGI
🧠 You’ll tackle questions such as:
How do GABA-based drinks compare to alcohol in modulating neural and behavioural states?
Can we identify biomarkers of response or cognitive enhancement?
Sept 2025 start! Apply -
findaphd.com/phds/project/fr…
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🚨 New preprint!
"Predictive Coding and Neurocomputational Psychiatry: A Mechanistic Framework for Understanding Mental Disorders"
read it: doi.org/10.31234/osf.io/wd23…
Alex 🇺🇦 retweeted
Premenstrual Dysphoric Disorder (PMDD) is not just “severe" Premenstrual Syndrome (PMS).
It affects 3–8% of women, leading to debilitating mood, cognitive, and physical symptoms due to altered neurosteroid sensitivity (Eisenlohr-Moul et al., 2017).
Here’s how neurosteroids impact PMDD & what every clinician needs to know. 🧵👇
Alex 🇺🇦 retweeted
Very proud of the team for showing that restoring GABA can mitigate behavioral & physiological deficits following frontotemporal lobar degeneration
A drug x MEG x PSP|FTD study #PSP #FTD
@wellcometrust @mrccbu @CambridgeBRC @CurePSP @PSPAssociation
alz-journals.onlinelibrary.w…
Alex 🇺🇦 retweeted
Clinical trials reveal that some antidepressants are over 100% more effective than placebo, while others barely outperform it.
The largest meta-analysis (Cipriani et al., 2018) compared 21 antidepressants in 116,477 patients, revealing striking differences in efficacy and tolerability.
Here’s what the study shows 🧵👇
Please do share and repost this PhD opportunity! It's a great opportunity to use computational methods to help elucidate the mechanisms of psychedelics... 🫶
🚨 Funded PhD opportunity! 🚨
"Computational Modelling of the Pharmacodynamics of Psychedelics"
Supervised by Dr Alexander Shaw and Prof Marc Goodfellow
Funded by EPSRC Doctoral Landscape Award
More info: lnkd.in/eXwv3ABm
Apply here: lnkd.in/es_9SSWK
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🚨 Funded PhD opportunity! 🚨
"Computational Modelling of the Pharmacodynamics of Psychedelics"
Supervised by Dr Alexander Shaw and Prof Marc Goodfellow
Funded by EPSRC Doctoral Landscape Award
More info: lnkd.in/eXwv3ABm
Apply here: lnkd.in/es_9SSWK
New preprint !
"Restoring Synaptic Balance in Schizophrenia: Insights from a thalamo-cortical conductance-based model."
biorxiv.org/content/10.1101/…
with @liobanause and @magnetokrishio.
Alex 🇺🇦 retweeted
The brain has a surge in functional connectivity moments before death:
pnas.org/doi/abs/10.1073/pna…
Interesting article!
Averaging is a convenient fiction of neuroscience - Mark Humphries
thetransmitter.org/neural-co…
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📢 PhD opportunity!
"Computing and translating mechanisms of neural network dysfunction associated with psychiatric risk"
A @GW4BioMedDTP project, supervised by Prof Matt Jones (Bris) and co-supervised Profs Jeremy Hall, Marianne van den Bree (Cardiff) & Me! (Exeter) ...
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"...electrophysiology and computational generative modelling, patient-public involvement and engagement (PPIE) with children and young people, to define the neural network mechanisms contributing to psychiatric risk in people living with psychosis-associated genetic mutations"
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Join our vibrant, innovative, supportive and collaborative team spanning Bristol, Exeter and Cardiff universities and encompassing genomic, cellular, circuit, cognitive and clinical analyses in patients and mice!
Apply: gw4biomed.ac.uk/computing-an…
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